CAS: 86050-77-3; Gadopentetate Dimeglumine

专利信息

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-11837354-B2
优先权日:2020-12-30
标题 :Contrast-agent-free medical diagnostic imaging
发明人：LI SHUO
权利人:LONDON HEALTH SCI CT RES INC
摘要:Described herein is medical imaging technology for concurrent and simultaneous synthesis of a medical CA-free-AI-enhanced image and medical diagnostic image analysis comprising: receiving a medical image acquired by a medical scanner in absence of contrast agent enhancement; providing the medical image to a computer-implemented machine learning model; concurrently performing a medical CA-free-AI-enhanced image synthesis task and a medical diagnostic image analysis task with the machine learning model; reciprocally communicating between the image synthesis task and the image analysis task for mutually dependent training of both tasks. Methods and systems and non-transitory computer readable media are described for execution of concurrent and simultaneous synthesis of a medical CA-free-AI-enhanced image and medical diagnostic image analysis.

专利号:US-11419953-B2
优先权日:2020-08-11
标 题:Reduced metastable complex macrocyclic contrast agents
发明人：DESLAURIERS RICHARD; MILBOCKER MICHAEL
权利人:INVENTURE LLC
摘要:Gadolinium based contrast agents (GCA) incorporating linear ligand chelation are fundamentally different from GCAs incorporating macrocyclic ligands. The macrocyclic\\GCAs are synthesized by pathways characterized by the formation of a sequence of metastable complexes before obtaining the final stable complex. The synthesis of linear GCAs do not form metastable complexes. Commercial macrocyclic GCAs contain unstable metastable complexes. These metastable species are not regulated and quickly release free Gd3+ ions upon administration into the body. Gadolinium based contrast agents with near zero metastable species content and methods of synthesizing the same are disclosed. Gadolinium based contrast agents with long dissociation time in the body, and low free Gd3+ ion formation are obtained using a synthesis method which departs in novel ways from the traditional free Gd3+-based synthesis methods.

专利号:US-2023382934-A1
优先权日:2022-05-27
标题:High entropy oxides and methods of synthesis and use thereof
发明人：GOLDSMITH CHRISTIAN R; KARBALAEI SANA
权利人:UNIV AUBURN
摘要:The present invention provides compositions of compounds comprising a metal M and a macrocyclic ligand represented by General Formula I, and contrast agents comprising the compositions thereof. In various embodiments, the present invention also relates to methods of enhancing methods of enhancing magnetic resonance imaging (MRI) in a living subject, the method comprising administering to a subject an effective amount of a contrast agent comprising a solution or suspension of the composition thereof.

专利号:US-11679168-B2
优先权日:2018-09-14
标 题 :Caspase-3-triggered molecular self-assembling PET probes and uses thereof
发明人：RAO JIANGHONG; CHENG YUNFENG; CHEN MIN; XIE JIANGHANG; CHEN ZIXIN
权利人:UNIV LELAND STANFORD JUNIOR; THE BOARD OF TRUSTEES OF LELAND STANFORD JUNIOR UNIV
摘要:Embodiments of the synthesis, radiolabeling and biological applications of an activatable tracer that undergoes intramolecular cyclization and aggregation upon activation by cleavage of a blocking moiety are provided. The probes of the disclosure allow for target-controlled self-assembly of small molecules in living subjects for imaging and drug delivery. The aggregated nanoprobes of the disclosure may be detectable optically, by PET detection, magnetic resonance imaging, and the like depending on the detectable reporter attached to the nanoprobe.

专利号:US-2022242885-A1
优先权日:2021-02-01
标 题 :Synthesis methods and compositions of low intermediate and low dichelate intermediate contrast agents
发明人：DESLAURIERS RICHARD J; MILBOCKER MICHAEL; LOMBARDO PAUL
权利人:INVENTURE LLC
摘要:Macrocyclic gadolinium-based contrast agents (GCA) are synthesized by pathways characterized by the formation of a sequence of metastable complexes before obtaining the final stable complex. Commercial macrocyclic GCAs contain unstable metastable complexes. These metastable species quickly release free Gd3+ ions upon delivery into the body. Aqueous or dry/solid GCA with near zero metastable species content and methods of synthesizing the same are disclosed.