CAS: 86-59-9; Quinoline-8-Carboxylic Acid

该化合物是一种有机化合物,其特点是由双环芳香系统组成的quinoline结构,由双环芳香系统组成,其特点是一个碳箱酸功能组(-COOH)和一个氢氧化物组(-OH),其位置为quinline环的8位置,其酸性更强;一种白色至黄色的黄色晶体,在水和酒精等极地溶剂中溶解. 8-基诺线碳箱酸展示发泡特性,使其形成稳定的复合金属离子,使其在各种应用中有用,包括分析化学和生物化学和生物化学化学.此外,该化合物还被研究其潜在的生物活动,包括抗微生物和抗癌特性.该化合物还被用于其他有机化合物的合成,并在各种化学反应中用作再试剂.在处理该物质时应采取安全防范措施,因为它在接触时可能对健康造成危害.

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CAS号611-32-5 8-甲基喹啉 | CAS号118-92-3 邻氨基苯甲酸 | CAS号56-81-5 甘油 | CAS号16567-18-3 8-溴喹啉 | CAS号124-38-9 二氧化碳 | CAS号38707-70-9 8-喹啉甲醛 | CAS号578-54-1 2-乙基苯胺 | CAS号19655-56-2 8-乙基喹啉 | CAS号72804-93-4 8-乙基-2-甲基喹啉 | CAS号72804-91-2 8-ethylquinolin... | CAS号107456-13-3 butyl quinoline... | CAS号34849-19-9 1,2,3,4-TETRAHY... | CAS号38707-70-9 8-喹啉甲醛 | CAS号40245-26-9 喹啉-8-甲酸甲酯 | CAS号89-00-9 吡啶-2,3-二羧酸 | CAS号56234-20-9 8-乙酰基喹啉 | CAS号25635-22-7 8-喹啉甲酸乙酯 | CAS号100517-41-7 8-喹啉 羰酰氯 | CAS号76971-22-7 Komarovidine | CAS号68056-49-5 N-(1H-Tetrazol-...

合成工艺路线路线简述

  • 16567-18-3 = 86-59-9
    反应条件:1.1 Reagents: Tert-Butyllithium Solvents: Diethyl Ether,Pentane; 20 Min,-78 °C; 10 Min,-78 °C1.2 -78 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 3
    标题:Development And Mechanistic Study Of Quinoline-Directed Acyl C-O Bond Activation And Alkene Oxyacylation Reactions
    作者:Hoang,Giang T.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2017 卷标:82(6) 页码:2972-2983]

    56-81-5 = 86-59-9
    反应条件:1.1 Reagents: 2-Nitrobenzoic Acid,Sulfuric Acid Solvents: Water
    标题:Concerning The Synthesis Of Pyrido-Benzo-Diazepines
    作者:Cmelka,Dieter
    参考文献:1969]

    16567-18-3 = 86-59-9
    反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether,Hexane; 2 H,-78 °C1.2 -78 °C -> Rt; Cooled1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 3,Cooled
    标题:Insertion Of An Alkene Into An Ester: Intramolecular Oxyacylation Reaction Of Alkenes Through Acyl C-O Bond Activation
    作者:Hoang,Giang T.; Et Al
    参考文献:Angewandte Chemie 日期:2011 卷标:50(8) 页码:1882-1884]

    56-81-5 = 86-59-9
    反应条件:1.1 Reagents: Sulfuric Acid Catalysts: Sodium Iodide Solvents: Water; 140 °C; 6.5 H,140 °C; 140 °C -> Rt1.2 Reagents: Hydroxide Solvents: Water; Neutralized,Rt
    标题:Synthesis Of Derivatives Of 2-Amino-4-Quinolones From 1,2,3,4-Tetrahydroquinoline-8-Carboxylic Acids
    作者:Listunov,Dimitriy; Et Al
    参考文献:Journal Of Heterocyclic Chemistry 日期:2013 卷标:50(3) 页码:660-662]

    56-81-5 = 86-59-9
    反应条件:1.1 Reagents: Sulfuric Acid Catalysts: Iodine; Overnight,140 °C; 140 °C -> Rt1.2 Solvents: Water; Rt -> 0 °C1.3 Reagents: Sodium Hydroxide; Neutralized; 0 °C -> Rt
    标题:Facile Access To Fused 2D/3D Rings Via Intermolecular Cascade Dearomative [2+2] Cycloaddition/rearrangement Reactions Of Quinolines With Alkenes
    作者:Ma,Jiajia; Et Al
    参考文献:Nature Catalysis 日期:2022 卷标:5(5) 页码:405-413]

    7496-46-0 = 86-59-9
    反应条件:1.1 Reagents: Nitric Acid,Mercury(1+) Salt,Hydrate (1:1:2) Solvents: 1,2-Dimethoxyethane; 2 H,Reflux1.2 Reagents: Triethylamine; 4 H,Reflux1.3 Reagents: 2-Methyl-2-Butene,Sodium Chlorite Solvents: Acetic Acid,Water; Rt; 16 H,Rt1.4 Reagents: Sodium Hydroxide Solvents: Water; Ph 12,Rt1.5 Reagents: Hydrogen Ion Solvents: Water; Ph 2,Rt
    标题:A Convenient Procedure For Indirect Oxidation Of Aromatic Methyl Groups To Aldehydes And Carboxylic Acids
    作者:Deady,Leslie W.; Et Al
    参考文献:Organic Preparations And Procedures International 日期:2003 卷标:35(6) 页码:627-630]

    56-81-5 = 86-59-9
    反应条件:1.1 Reagents: Methanesulfonic Acid,Benzenesulfonic Acid,3-Nitro-,Sodium Salt (1:1),Ferrous Sulfate2.1 Reagents: Tert-Butyllithium Solvents: Diethyl Ether,Pentane; 20 Min,-78 °C; 10 Min,-78 °C2.2 -78 °C2.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 3
    标题:Development And Mechanistic Study Of Quinoline-Directed Acyl C-O Bond Activation And Alkene Oxyacylation Reactions
    作者:Hoang,Giang T.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2017 卷标:82(6) 页码:2972-2983
📜2-乙基苯胺置于盐酸,Potassium Dichromate,Selenium(Iv) Oxide,乙醇,硫酸,双氧水,丙酮,Zinc(II) Chloride体系中,化学反应生成 8-喹啉甲酸
参考文献:The Nitrogen Compounds In Petroleum Distillates. Xx. Isolation Of 2-Methyl-8-Ethylquinoline From California Petroleum And Proof Of Structure Through Degradation And Synthesis
标题:The Nitrogen Compounds In Petroleum Distillates. Xx. Isolation Of 2-Methyl-8-Ethylquinoline From California Petroleum And Proof Of Structure Through Degradation And Synthesis
摘要:
DOI:10.1021/ja01848A002

海关参考信息

专利信息


专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-8022217-B2
优先权日:2006-07-31
标 题 :Compounds suitable as modulators of HDL
发明人：THOMBARE PRAVIN S; LOHRAY BRAJ BHUSHAN; LOHRAY VIDYA BHUSHAN; PATL PANKAJ RAMANBHAI
权利人:CADILA HEALTHCARE LTD
摘要:Disclosed herein in the embodiments of the present invention are the compounds suitable as modulators of HDL having general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:EP-1957644-B1
优先权日:2005-12-01
标 题 :Enzymatic encoding methods for efficient synthesis of large libraries

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参考文献:10.1007/s00216-011-5225-7
摘要:Shibata S, Zhang Z, Korotkov KV, Delarosa J, Napuli A, Kelley AM, Mueller N, Ross J, Zucker FH, Buckner FS, Merritt EA, Verlinde CLMJ, Van Voorhis WC, Hol WGJ, Fan E. Screening a fragment cocktail library using ultrafiltration. Analytical and Bioanalytical Chemistry. 2011 Jul 13;401(5):1585. doi: 10.1007/s00216-011-5225-7.
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