专利号:US-10925977-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications 发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S 权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS 摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:EP-1105359-B1 优先权日:1998-08-21 标 题:Solid phase synthesis of compounds by carbon-carbon bond forming mitsunobu reactions 发明人:CHATURVEDI SURENDRAKUMAR 权利人:PE CORP NY 摘要:Processes are provided for the Mitsunobu alkylation reaction of carbon-carbon bond formation between a solid support reagent and a reagent in solution. The resulting novel products can be prepared as a combinatorial library by high-throughput, parallel synthesis under robotic automation. Cleaved or support-bound products are useful precursors to biologically active compounds.
专利号:US-10814013-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:US-2025161372-A1 优先权日:2023-11-22 标 题 :Engineered probiotics and the applications thereof 发明人:PHAM QUYNH HOA; LAU CHI KONG; BAN KIWON; BUI THI VAN ANH 权利人:UNIV CITY HONG KONG 摘要:A genetically engineered strain of Escherichia coli Nissle 1917 (EcN) with a modified genome designed to enhance the production of short-chain fatty acids (SCFAs) is provided. The engineered genome includes the atoB gene from E. coli K-12, responsible for encoding acetyl-CoA acetyltransferase, a crt-bcd-etfA-etfB-BHBD gene cluster from E. C. butyricum that encodes enzymes involved in the synthesis of SCFAs, specifically enoyl-CoA hydratase, butyryl-CoA dehydrogenase, and electron transfer flavoproteins, and the ptb-buk gene from C. acetobutyricum, which encodes phosphotransbutyrylase and butyrate kinase. Additionally, key genes associated with competing metabolic pathways—ldhA, frdABCD, adhE, ackA, and pta—are deleted to optimize SCFA production, particularly butyrate. This strain is intended for use in therapeutic applications where enhanced SCFA production is beneficial, such as in the treatment of coronary heart disease.
专利号:AU-2006346193-A2 优先权日:2006-07-07 标 题:An enantioselective synthesis of pyrrolidine-substituted flavones
专利号:AU-2006346193-C1 优先权日:2006-07-07 标题:An enantioselective synthesis of pyrrolidine-substituted flavones
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合成参考文献
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