CAS: 84-36-6; Methyl (1R,15S,17R,18R,19S,20S)-17-(4-Ethoxycarbonyloxy-3,5-Dimethoxybenzoyl)Oxy-6,18-Dimethoxy-1,3,11,12,14,15,16,17,18,19,20,21-Dodecahydroyohimban-19-Carboxylate

该化合物是来自Rauwolfia蛇的抗血压和镇静剂类碱性物质,作为类似转基因的化合物,抑制子宫单胺运输器(VMAT1和VMAT2),从而耗竭...

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4-ethoxycarbonyloxy-3,5-dimethoxy-benzoyl chloride methyl reserpate2,10.04,9.015,20]henicosa-2(10),4,6,8-tetraene-19-carboxylatemethyl (1R,15S,17R,18R,19S,20S)-17-[(4-hydroxy-3,5-dimethoxyphenyl)carbonyloxy]-6,18-dimethoxy-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8-tetraene-19-carboxylate ent-18α-(4-acetoxy-3,5-dimethoxy-benzoyloxy)-11,17β-dimethoxy-15β-yohimban-16α-carboxylic acid methyl esterent-18α-(4-acetoxy-3,5-dimethoxy-benzoyloxy)-11,17β-dimethoxy-15β-yohimban-16α-carboxylic acid methyl ester ent-18α-(4-ethylcarbamoyloxy-3,5-dimethoxy-benzoyloxy)-11,17β-dimethoxy-15β-yohimban-16α-carboxylic acid methyl esterent-18α-(4-ethylcarbamoyloxy-3,5-dimethoxy-benzoyloxy)-11,17β-dimethoxy-15β-yohimban-16α-carboxylic acid methyl ester

合成工艺路线路线简述

    📜4-Ethoxycarbonyl-Oxy-3,5-Dimethoxy-Benzoyl Chloride,(3Beta,16Beta,17Alpha,18Beta,20Alpha)-18-羟基-11,17-二甲氧基育亨宾-16-羧酸甲酯 反应生成 乙酯利血平
    参考文献:Us2813871
    标题:Us2813871

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    专利信息


    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:EP-1105359-B1
    优先权日:1998-08-21
    标 题:Solid phase synthesis of compounds by carbon-carbon bond forming mitsunobu reactions
    发明人:CHATURVEDI SURENDRAKUMAR
    权利人:PE CORP NY
    摘要:Processes are provided for the Mitsunobu alkylation reaction of carbon-carbon bond formation between a solid support reagent and a reagent in solution. The resulting novel products can be prepared as a combinatorial library by high-throughput, parallel synthesis under robotic automation. Cleaved or support-bound products are useful precursors to biologically active compounds.

    专利号:US-10814013-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:US-2025161372-A1
    优先权日:2023-11-22
    标 题 :Engineered probiotics and the applications thereof
    发明人:PHAM QUYNH HOA; LAU CHI KONG; BAN KIWON; BUI THI VAN ANH
    权利人:UNIV CITY HONG KONG
    摘要:A genetically engineered strain of Escherichia coli Nissle 1917 (EcN) with a modified genome designed to enhance the production of short-chain fatty acids (SCFAs) is provided. The engineered genome includes the atoB gene from E. coli K-12, responsible for encoding acetyl-CoA acetyltransferase, a crt-bcd-etfA-etfB-BHBD gene cluster from E. C. butyricum that encodes enzymes involved in the synthesis of SCFAs, specifically enoyl-CoA hydratase, butyryl-CoA dehydrogenase, and electron transfer flavoproteins, and the ptb-buk gene from C. acetobutyricum, which encodes phosphotransbutyrylase and butyrate kinase. Additionally, key genes associated with competing metabolic pathways—ldhA, frdABCD, adhE, ackA, and pta—are deleted to optimize SCFA production, particularly butyrate. This strain is intended for use in therapeutic applications where enhanced SCFA production is beneficial, such as in the treatment of coronary heart disease.

    专利号:AU-2006346193-A2
    优先权日:2006-07-07
    标 题:An enantioselective synthesis of pyrrolidine-substituted flavones

    专利号:AU-2006346193-C1
    优先权日:2006-07-07
    标题:An enantioselective synthesis of pyrrolidine-substituted flavones

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    主要参考文献


    1: SHELBURNE PF, ORGAIN ES. Comparison of syrosingopine and reserpine in the treatment of ambulatory hypertensive patients. Am J Med Sci. 1963 Mar;245:304-10. doi: 10.1126/sciadv.1601756. eCollection 2016 Dec.
    9: BARE WW. Hypertension and edema in the aged. Comparison of hydrochlorothiazide and a hydrochlorothiazide-syrosingopine combination. J Am Geriatr Soc. 1960 Oct;8:795-802.
    15: SCHMITT H. [Hypertensive action of syrosingopine after ephedrine]. C R Seances Soc Biol Fil. 1960;154:55-7. French.

    合成参考文献


    摘要:Drugs in Japan, 6(365), 1982
    摘要:Iyakuhin Kenkyu. Study of Medical Supplies., 6(386), 1975
    参考文献:10.3181/00379727-99-24328
    摘要:BACHRACH WH. Comparison of effect of reserpine and syrosingopine on gastric acid secretion. Proc Soc Exp Biol Med. 1958 Nov;99(2):295–6. doi: 10.3181/00379727-99-24328.
    参考文献:10.1016/0002-9149(61)90484-2
    摘要:Raab W, Marchet H, Herrlich HC. Effect of reserpine and syrosingopine on the rate and contractility of the human heart. The American Journal of Cardiology. 1961 Mar;7(3):404–11. doi: 10.1016/0002-9149(61)90484-2.
    摘要:LEROY JG, DE SCHAEPDRYVER AF. Catecholamine levels of brain and heart in mice after iproniazid, syrosingopine and 10-methoxydeserpidine. Arch Int Pharmacodyn Ther. 1961 Feb 01;130():231–4.
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