CAS: 835-78-9; (2-Phenethylphenyl)Methanol

该化合物是一种多用途芳香醇,其特征是苯和苯乙基替代成分,提供了平衡的对应性和稳定性组合,其结构使其作为有机合成的中间体,特别是制药,农用化学品和特殊化学品具有价值.苯基氢氧基组为进一步衍生,促进诸如酯化,乙化或氧化等变异提供了功能性处理器.苯乙基会增强脂性,这在设计生物活性化合物方面可能具有优势.该化合物展示普通有机溶剂的中等溶性,便利其在多步骤合成途径的使用.其定义明确的结构和纯度使其适合于需要精确分子控制的研究和工业应用.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号4890-85-1 邻苯乙基苯甲酸 | CAS号17376-04-4 2-(碘乙基)苯(含稳定剂铜屑) | CAS号5159-41-1 2-碘苄醇 | CAS号100-39-0 溴化苄 | CAS号74785-02-7 2-(溴甲基)苄醇 | CAS号833-48-7 10,11-二氢-5H-二苯并... | CAS号32832-96-5 2-苯乙基苯甲醛 | CAS号22253-11-8 2-phenyl-2,3-di...

合成工艺路线路线简述

  • 4890-85-1 = 835-78-9
    反应条件:1.1 Reagents: Lithium Aluminum Hydride
    标题:An Improved Medium-Scale Preparation Of Dibenzo[a,E]Cycloocten-5(6H),11(12H)-Dione
    作者:Moore,J. A.; Et Al
    参考文献:Organic Preparations And Procedures International 日期:1984 卷标:16(6) 页码:411-25]

    4890-85-1 = 835-78-9
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Diethyl Ether; 0 °C; 2 H,40 °C1.2 Reagents: Sodium Sulfate Decahydrate; Rt
    标题:Transformation Of Trifluorotoluenes Triggered By Titanium(Iv) Chloride-Catalyzed Hydrodefluorination Using Hydrosilanes
    作者:Yamada,Takayuki; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2016 卷标:358(1) 页码:62-66]

    4890-85-1 = 835-78-9
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Diethyl Ether; 25 Min,0 °C; 3 H,Rt1.2 Reagents: Sodium Sulfate Decahydrate; 1 H,Rt
    标题:Expeditious Construction Of A Carbobicyclic Skeleton Via Sp3-C-H Functionalization: Hydride Shift From An Aliphatic Tertiary Position In An Internal Redox Process
    作者:Mori,Keiji; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2011 卷标:133(8) 页码:2424-2426]

    74785-02-7 = 835-78-9
    反应条件:1.1 Catalysts: Dimanganese Decacarbonyl Solvents: Dichloromethane
    标题:Efficient Radical Coupling Of Organobromides Using Dimanganese Decacarbonyl
    作者:Gilbert,Bruce C.; Et Al
    参考文献:Synthetic Communications 日期:1999 卷标:29(15) 页码:2711-2718]

    5159-41-1 + 17376-04-4 = 835-78-9
    反应条件:1.1 Reagents: Indium,Cuprous Chloride Solvents: Tetrahydrofuran; 24 H,Rt1.2 Reagents: Lithium Chloride Catalysts: Dichlorobis(Triphenylphosphine)Palladium Solvents: Dimethylacetamide; 24 H,100 °C
    标题:Direct Synthesis Of Water-Tolerant Alkyl Indium Reagents And Their Application In Palladium-Catalyzed Couplings With Aryl Halides
    作者:Shen,Zhi-Liang; Et Al
    参考文献:Angewandte Chemie 日期:2011 卷标:50(2) 页码:511-514]

    575-61-1 = 835-78-9
    反应条件:1.1 -2.1 Reagents: Lithium Aluminum Hydride
    标题:An Improved Medium-Scale Preparation Of Dibenzo[a,E]Cycloocten-5(6H),11(12H)-Dione
    作者:Moore,J. A.; Et Al
    参考文献:Organic Preparations And Procedures International 日期:1984 卷标:16(6) 页码:411-25
📜Methyl 2-(2-Phenylethyl)Benzoate置于lithium Aluminium Tetrahydride体系中,用 乙醚 作为反应溶剂,化学反应 4.0H,以70%的收率获得产物2-苯乙基苯甲醇
参考文献:Carrara,Maria; Zampiron,Stefano; Pittarello,Demetrio,Arzneimittel-Forschung/drug Research,1997,Vol. 47,# 7,P. 803-809
标题:Carrara,Maria; Zampiron,Stefano; Pittarello,Demetrio,Arzneimittel-Forschung/drug Research,1997,Vol. 47,# 7,P. 803-809

海关参考信息

专利信息


专利号:US-7825149-B2
优先权日:2006-01-19
标 题 :Substituted imidazoles
发明人：CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE
权利人:PFIZER LTD
摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

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合成参考文献

参考DOI号:10.1016/S0040-4020(97)00338-4
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