CAS: 83011-43-2; Methyl 3-Hydroxy-4,5-Dimethoxybenzoate

该化合物是属于苯甲酸类的有机化合物,是来自苯甲胺的酯类或盐类;该化合物的特点是3和4个位置用两种甲氧基组(-OCH3)替代的苯环,5个位置上用氢氧组(OH)替代,有助于其潜在的生物活动;这些功能组的存在表明,它可能表现出抗氧化特性,并可能参与各种生物化学途径;甲氧组增强分子的亲脂性,有可能影响其溶性及生物系统中的渗透性;此外,氢氧类可以参与氢结合,这可能影响化合物的再活动以及与其他分子的相互作用;总体而言,3,4-二甲基氧氧基-5氢氧苯并具有对医药化学和药理学等领域的兴趣,这些领域的结构性特征可用于治疗用途.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号67-56-1 甲醇 | CAS号1916-08-1 5-羟基-3,4-二甲氧基苯甲酸 | CAS号26409-24-5 methyl 3-benzyl... | CAS号99-24-1 没食子酸甲酯 | CAS号74-88-4 碘甲烷 | CAS号24093-81-0 3,5-二羟基-4-甲氧基苯甲酸甲酯 | CAS号79831-86-0 methyl 3-(benzy... | CAS号186581-53-3 重氮甲烷 | CAS号149-91-7 没食子酸; 3,4,5-三羟基苯甲酸 | CAS号77-78-1 硫酸二甲酯 | CAS号1916-07-0 3,4,5-三甲氧基苯甲酸甲酯 | CAS号2555-99-9 VANILLIC ACID, ... | CAS号101289-41-2 3,4-dimethoxy-5... | CAS号192315-05-2 2-环丙基-7,8-二甲氧基-... | CAS号1916-08-1 5-羟基-3,4-二甲氧基苯甲酸

合成工艺路线路线简述

  • 合成目标产物 Methyl 4,5-Dimethoxy-3-Hydroxybenzoate 主要起始原料 Methanol And 3-Hydroxy-4,5-Dimethoxybenzoic Acid
  • 1916-08-1 = 83011-43-2
    反应条件:1.1 Reagents: Hydrochloric Acid
    标题:Enantioselective Synthesis And Photoracemization Studies Of (+)-2-Cyclopropyl-7,8-Dimethoxy-2H-Chromene-5-Carboxylic Acid Methyl Ester,An Advanced Intermediate Of A Dihydrofolate Reductase Inhibitor
    作者:Wipf,Peter; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1999 卷标:64(14) 页码:5321-5324]

    26409-24-5 = 83011-43-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 24 H,Rt
    标题:Intramolecular Biaryl Coupling Reaction Of Benzyl Benzoate And Phenyl Benzoate Derivatives,And Its Application To The Formal Synthesis Of (-)-Steganone
    作者:Takeda,Shigemitsu; Et Al
    参考文献:Tetrahedron 日期:2007 卷标:63(2) 页码:396-408]

    99-24-1 = 83011-43-2
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 30 Min,Rt1.2 Rt; 2 H,Rt
    标题:Synthesis And Anti-Platelet Activity Of Obovatol Derivatives
    作者:Kwak,Jae-Hwan; Et Al
    参考文献:Archives Of Pharmacal Research 日期:2011 卷标:34(7) 页码:1107-1112]

    99-24-1 = 83011-43-2
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 0 °C
    标题:Synthesis Of Obovatol Derivatives And Their Preliminary Evaluation As Antitumor Agents
    作者:Lee,Mi-Sung; Et Al
    参考文献:Bulletin Of The Korean Chemical Society 日期:2007 卷标:28(9) 页码:1601-1604]

    149-91-7 = 83011-43-2
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 25 Min,Rt; 100 Min,Rt; 1 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt1.3 Reagents: Sulfuric Acid Solvents: Methanol,Dichloromethane,Water; 24 H,Reflux1.4 Reagents: Hydrochloric Acid Solvents: Water; Rt1.5 Reagents: Potassium Carbonate Solvents: Water; Neutralized,Rt1.6 Reagents: Sodium Carbonate Solvents: Water; Rt1.7 Reagents: Sodium Hydroxide Solvents: Water; 30 Min,50 °C; 50 °C -> Rt1.8 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,Rt
    标题:Synthesis And Biological Evaluation Of Phenstatin Metabolites
    作者:Ghinet,Alina; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2011 卷标:19(20) 页码:6042-6054]

    149-91-7 = 83011-43-2
    反应条件:1.1 Reagents: Sulfuric Acid Solvents: Methanol,Water2.1 Reagents: Sulfuric Acid Solvents: Dichloromethane
    标题:Synthesis Of Isoflavones. V. Irigenin And Tectorigenin
    作者:Baker,Wilson; Et Al
    参考文献:Journal Of The Chemical Society [section] C: Organic 日期:1970 卷标:(9) 页码:1219-23]

    99-24-1 = 83011-43-2 + 24093-81-0
    反应条件:1.1 Reagents: Lithium Carbonate (Li2Co3) Solvents: Dimethylformamide; 18 H,50 - 55 °C
    标题:Multi-Functionalization Of Gallic Acid Towards Improved Synthesis Of α- And β-Ddb
    作者:Alam,Ashraful; Et Al
    参考文献:Tetrahedron 日期:2005 卷标:61(7) 页码:1909-1918]

    925203-37-8 = 83011-43-2
    反应条件:1.1 Reagents: Tributylphosphine,1,3-Bis(Diphenylphosphino)Propane,Diisopropylethylamine Catalysts: Palladium Diacetate Solvents: Dimethylformamide; 3 H,130 °C; Cooled
    标题:Intramolecular Biaryl Coupling Reaction Of Benzyl Benzoate And Phenyl Benzoate Derivatives,And Its Application To The Formal Synthesis Of (-)-Steganone
    作者:Takeda,Shigemitsu; Et Al
    参考文献:Tetrahedron 日期:2007 卷标:63(2) 页码:396-408]

    24093-81-0 + 619-42-1 = 83011-43-2 + 24093-81-0
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Copper Oxide (Cuo) Solvents: Pyridine2.1 Reagents: Diazomethane Solvents: Dichloromethane
    标题:Synthesis Of Perrottetin F And G,Two Linear Bis(Bibenzyl) Ethers From Radula Perrottetii
    作者:Mezey-Vandor,Gabriella; Et Al
    参考文献:Liebigs Annalen Der Chemie 日期:1989 卷标:(4) 页码:401-3]

    26409-24-5 = 83011-43-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 24 H,Rt2.1 Reagents: 1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 1 H,Rt3.1 Reagents: Tributylphosphine,1,3-Bis(Diphenylphosphino)Propane,Diisopropylethylamine Catalysts: Palladium Diacetate Solvents: Dimethylformamide; 3 H,130 °C; Cooled
    标题:Intramolecular Biaryl Coupling Reaction Of Benzyl Benzoate And Phenyl Benzoate Derivatives,And Its Application To The Formal Synthesis Of (-)-Steganone
    作者:Takeda,Shigemitsu; Et Al
    参考文献:Tetrahedron 日期:2007 卷标:63(2) 页码:396-408]

    665004-31-9 = 83011-43-2
    反应条件:1.1 Reagents: Diisobutylaluminum Hydride Solvents: Toluene; -78 °C; 1 H,-78 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; 30 Min,Rt2.1 Reagents: Chromium Trioxide Solvents: Acetone; 0 - 5 °C; 5 Min,0 °C2.2 Reagents: Sodium Bisulfite Solvents: Water; 0 °C2.3 Reagents: Monosodium Phosphate,Hydrogen Peroxide,Sodium Chlorite Solvents: Acetonitrile,Water; 0 - 5 °C; 2 H,Rt2.4 Reagents: Sodium Bisulfite Solvents: Water; Rt3.1 Reagents: 1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 1 H,Rt4.1 Reagents: Tributylphosphine,1,3-Bis(Diphenylphosphino)Propane,Diisopropylethylamine Catalysts: Palladium Diacetate Solvents: Dimethylformamide; 3 H,130 °C; Cooled
    标题:Intramolecular Biaryl Coupling Reaction Of Benzyl Benzoate And Phenyl Benzoate Derivatives,And Its Application To The Formal Synthesis Of (-)-Steganone
    作者:Takeda,Shigemitsu; Et Al
    参考文献:Tetrahedron 日期:2007 卷标:63(2) 页码:396-408]

    1916-08-1 = 83011-43-2
    反应条件:1.1 Reagents: Sulfuric Acid Solvents: Dichloromethane
    标题:Synthesis Of Isoflavones. V. Irigenin And Tectorigenin
    作者:Baker,Wilson; Et Al
    参考文献:Journal Of The Chemical Society [section] C: Organic 日期:1970 卷标:(9) 页码:1219-23]

    99-24-1 = 83011-43-2
    反应条件:1.1 Reagents: Triethyl Orthoformate Catalysts: Amberlyst 15 Solvents: Benzene1.2 Reagents: Benzyl Bromide,Potassium Carbonate Solvents: Dimethylformamide1.3 Reagents: Potassium Carbonate Solvents: Acetone1.4 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol
    标题:Total Syntheses Of The Metabolites Of Schizandrin
    作者:Tanaka,Masahide; Et Al
    参考文献:Tetrahedron 日期:1995 卷标:51(43) 页码:11703-24]

    192315-04-1 = 83011-43-2 [标题:Reaction Conditions
    标题:Pt(Iv)-Catalyzed Cyclization Of Arene-Alkyne Substrates Via C-H Bond Functionalization
    作者:Pastine,Stefan J.; Et Al
    参考文献:Tetrahedron 日期:2003 卷标:59(45) 页码:8859-8868]

    24093-81-0 = 83011-43-2
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 50 - 55 °C
    标题:Multi-Functionalization Of Gallic Acid Towards Improved Synthesis Of α- And β-Ddb
    作者:Alam,Ashraful; Et Al
    参考文献:Tetrahedron 日期:2005 卷标:61(7) 页码:1909-1918]

    149-91-7 = 83011-43-2
    反应条件:1.1 Reagents: Sulfuric Acid Solvents: Water; 6 H,Reflux2.1 Reagents: Lithium Carbonate (Li2Co3) Solvents: Dimethylformamide; 18 H,50 - 55 °C3.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 50 - 55 °C
    标题:Multi-Functionalization Of Gallic Acid Towards Improved Synthesis Of α- And β-Ddb
    作者:Alam,Ashraful; Et Al
    参考文献:Tetrahedron 日期:2005 卷标:61(7) 页码:1909-1918]

    99-24-1 = 83011-43-2 + 24093-81-0
    反应条件:1.1 Reagents: Diazomethane Solvents: Dichloromethane
    标题:Synthesis Of Perrottetin F And G,Two Linear Bis(Bibenzyl) Ethers From Radula Perrottetii
    作者:Mezey-Vandor,Gabriella; Et Al
    参考文献:Liebigs Annalen Der Chemie 日期:1989 卷标:(4) 页码:401-3]

    149-91-7 = 83011-43-2 + 24093-81-0
    反应条件:1.1 Reagents: Sulfuric Acid Solvents: Water; 6 H,Reflux2.1 Reagents: Lithium Carbonate (Li2Co3) Solvents: Dimethylformamide; 18 H,50 - 55 °C
    标题:Multi-Functionalization Of Gallic Acid Towards Improved Synthesis Of α- And β-Ddb
    作者:Alam,Ashraful; Et Al
    参考文献:Tetrahedron 日期:2005 卷标:61(7) 页码:1909-1918]

    60229-66-5 + 83011-43-2 = 83011-43-2
    反应条件:1.1 Reagents: 1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 1 H,Rt2.1 Reagents: Tributylphosphine,1,3-Bis(Diphenylphosphino)Propane,Diisopropylethylamine Catalysts: Palladium Diacetate Solvents: Dimethylformamide; 3 H,130 °C; Cooled
    标题:Intramolecular Biaryl Coupling Reaction Of Benzyl Benzoate And Phenyl Benzoate Derivatives,And Its Application To The Formal Synthesis Of (-)-Steganone
    作者:Takeda,Shigemitsu; Et Al
    参考文献:Tetrahedron 日期:2007 卷标:63(2) 页码:396-408]

    69048-76-6 = 83011-43-2
    反应条件:1.1 Reagents: Chromium Trioxide Solvents: Acetone; 0 - 5 °C; 5 Min,0 °C1.2 Reagents: Sodium Bisulfite Solvents: Water; 0 °C1.3 Reagents: Monosodium Phosphate,Hydrogen Peroxide,Sodium Chlorite Solvents: Acetonitrile,Water; 0 - 5 °C; 2 H,Rt1.4 Reagents: Sodium Bisulfite Solvents: Water; Rt2.1 Reagents: 1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 1 H,Rt3.1 Reagents: Tributylphosphine,1,3-Bis(Diphenylphosphino)Propane,Diisopropylethylamine Catalysts: Palladium Diacetate Solvents: Dimethylformamide; 3 H,130 °C; Cooled
    标题:Intramolecular Biaryl Coupling Reaction Of Benzyl Benzoate And Phenyl Benzoate Derivatives,And Its Application To The Formal Synthesis Of (-)-Steganone
    作者:Takeda,Shigemitsu; Et Al
    参考文献:Tetrahedron 日期:2007 卷标:63(2) 页码:396-408]

    495-76-1 = 83011-43-2
    反应条件:1.1 Reagents: Silver Trifluoroacetate,Iodine Solvents: Chloroform; 10 Min,-5 °C2.1 Reagents: Chromium Trioxide Solvents: Acetone; 0 - 5 °C; 5 Min,0 °C2.2 Reagents: Sodium Bisulfite Solvents: Water; 0 °C2.3 Reagents: Monosodium Phosphate,Hydrogen Peroxide,Sodium Chlorite Solvents: Acetonitrile,Water; 0 - 5 °C; 2 H,Rt2.4 Reagents: Sodium Bisulfite Solvents: Water; Rt3.1 Reagents: 1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 1 H,Rt4.1 Reagents: Tributylphosphine,1,3-Bis(Diphenylphosphino)Propane,Diisopropylethylamine Catalysts: Palladium Diacetate Solvents: Dimethylformamide; 3 H,130 °C; Cooled
    标题:Intramolecular Biaryl Coupling Reaction Of Benzyl Benzoate And Phenyl Benzoate Derivatives,And Its Application To The Formal Synthesis Of (-)-Steganone
    作者:Takeda,Shigemitsu; Et Al
    参考文献:Tetrahedron 日期:2007 卷标:63(2) 页码:396-408
📜没食子酸置于硫酸体系中,化学反应生成 3,4-二甲氧基-5-羟基苯甲酸甲酯
参考文献:异黄酮的合成.第五部分irigenin和tectorigenin
标题:异黄酮的合成.第五部分irigenin和tectorigenin
摘要:合成异黄酮的一般乙氧基化方法已应用于合成irigenin(vii)和tectorigenin(xvi).该合成途径也产生了异构体,ψ-Irigenin(xi)和ψ-Tectorigenin(xx).讨论了有关某些乙氧基化反应中产物比例以及5,6,7-和5,7,8-三取代异黄酮的相对热力学稳定性的信息.
DOI:10.1039/j39700001219

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专利信息


专利号:US-2015057366-A1
优先权日:2012-03-05
标题 :Synthesis of elemicin and topical analgesic compositions
发明人：LA GRANGE MARTIN JAMES
权利人:LA GRANGE MARTIN JAMES
摘要:The present invention is directed to the synthesis of elemicin and its isomeric form, and their use in topical analgesic formulations, including for dental and veterinary use. Various compositions include gels, films, dressings, cavity filling gels, having analgesic and/or antifungal properties.

专利号:WO-2013133723-A1
优先权日:2012-03-05
标题:Synthesis of elemicin and topical analgesic compositions

专利号:US-7691843-B2
优先权日:2002-07-11
标 题 :N-hydroxyamide derivatives possessing antibacterial activity
发明人：RAJU BORE G; O'DOWD HARDWIN; GAO HONGWU; PATEL DINESH V; TRIAS JAOQUIM
权利人:PFIZER
摘要:Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.

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主要参考文献

[参考文献]: Wei Tian, Et Al. Identification Of Gallicin From Myricaria Laxiflora And Its Antibiotic & Antioxidant Activity.

合成参考文献


参考文献:10.1007/s12272-011-0708-9
摘要:Kwak JH, Lee S, Park ES, In JK, Song J, Kim YJ, Choi NS, Lee H, Yun YP, Hong JT, Kwak YS, Min KH, Jung JK. Synthesis and anti-platelet activity of obovatol derivatives. Arch Pharm Res. 2011 Jul;34(7):1107–12. doi: 10.1007/s12272-011-0708-9.
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