85612-35-7 = 830-96-6 反应条件:1.1 Reagents: Sodium Hydroxide 标题:Indobine - A New Alkaloid From Rauwolfia Serpentina Benth 作者:Siddiqui,Salimuzzaman; Et Al 参考文献:Zeitschrift Fuer Naturforschung 日期:1987 卷标:42(6) 页码:783-4]
40641-03-0 = 830-96-6 反应条件:1.1 Solvents: Water; 24 H,30 °C 标题:Biocatalytic Hydrolysis Of Various Esters Using Baker'S Yeast Under Neutral Conditions Without Sucrose 作者:Noguchi,Takuya; Et Al 参考文献:Tetrahedron Letters 日期:2022 卷标:104]
72651-98-0 = 830-96-6 反应条件:1.1 Reagents: Water Solvents: Water 标题:Two Efficient Syntheses Of Indole-3-Propionic Esters And Acids. Further Applications Of Meldrum'S Acid 作者:Farlow,Diane S.; Et Al 参考文献:Organic Preparations And Procedures International 日期:1981 卷标:13(1) 页码:39-48]
120-72-9 = 830-96-6 反应条件:1.1 Solvents: Water 标题:Mechanisms Of Hydrolysis Of Several Atom-Bridged Bicyclic Anhydrides,N-Methylimides,And Lactones 作者:Hall,H. K. Jr. 参考文献:Journal Of Organic Chemistry 日期:1963 卷标:28(8) 页码:2027-9]
29953-71-7 = 830-96-6 反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl Acetate; 12 H,Rt 标题:Improved Synthesis Of Natural Ester Sintenin And Its Analogues Via Wittig Reaction 作者:Sharma,Mukul; Et Al 参考文献:Journal Of The Indian Chemical Society 日期:2013 卷标:90(10) 页码:1853-1860]
109897-76-9 = 830-96-6 反应条件:1.1 Reagents: Sodium Hydroxide 标题:Isolation Of Indobinine,A New Alkaloid From Roots Of Rauwolfia Serpentina Benth 作者:Siddiqui,Salimuzzaman; Et Al 参考文献:Indian Journal Of Chemistry 日期:1987 卷标:(3) 页码:279-80]
40641-03-0 = 830-96-6 反应条件:1.1 Reagents: Sodium Hydroxide; 1 H,Reflux 标题:Beckmann Rearrangement For The Synthesis Of Derivatives Of β- And γ-Carbolinones,Dihydropyrrolopyridinone And Tetrahydroisoquinolinone 作者:Naik,Prajakta N.; Et Al 参考文献:Arkivoc (Gainesville 日期:2015 卷标:(7) 页码:362-376]
72651-98-0 = 830-96-6 反应条件:1.1 Reagents: Water Solvents: Pyridine; 16 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified 标题:Ethylenation Of Aldehydes To 3-Propanal,Propanol And Propanoic Acid Derivatives 作者:Payne,Daniel T.; Et Al 参考文献:Scientific Reports 日期:2017 卷标:7(1) 页码:1-8]
120-72-9 + 4743-82-2 = 830-96-6 反应条件:1.1 Catalysts: Acetic Acid,Tetraanhydride With Boric Acid (H4B2O5) Solvents: Acetonitrile; 1 Min,Rt 标题:B-O-B Catalyzed Cycloadditions Of Acrylic Acids 作者:Zhang,Peng; Et Al 参考文献:Acs Sustainable Chemistry & Engineering 日期:2016 卷标:4(12) 页码:6991-6995]
31529-28-9 = 830-96-6 [标题:Reaction Conditions 标题:Syntheses Starting From 2-Cyanocyclopentanone. Application Of Arylhydrazones Of 5-Cyano-5-Oxopentanoic Acid To The Preparation Of Indole Derivatives 作者:Thi Anh Nga Trinh; Et Al 参考文献:Bulletin De La Societe Chimique De France 日期:1987 卷标:(2) 页码:361-4]
160320-11-6 = 830-96-6 反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; 0 °C; 2 H,40 - 45 °C; Cooled1.2 Reagents: Ammonium Chloride Solvents: Water; Rt 标题:A Systematic Study Of Two Complementary Protocols Allowing The General,Mild And Efficient Deprotection Of N-Pivaloylindoles 作者:Ruiz,Miriam; Et Al 参考文献:Tetrahedron 日期:2012 卷标:68(2) 页码:705-710]
160320-11-6 = 830-96-6 反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran,Hexane; -78 °C; 2 H,40 - 45 °C; 45 °C -> Rt1.2 Reagents: Ammonium Chloride Solvents: Water; Rt 标题:An Efficient Procedure For The Deprotection Of N-Pivaloylindoles,Carbazoles And β-Carbolines With Lda 作者:Avendano,Carmen; Et Al 参考文献:Synlett 日期:2005 卷标:(1) 页码:107-110]
160320-11-6 = 830-96-6 反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; 2 H,40 - 45 °C1.2 Reagents: Water 标题:Deprotection Of N-Pivaloylindoles,Carbazoles And Beta-Carbolines With A Lithium Base 作者:Sanchez,J. Domingo; Et Al 参考文献:International Electronic Conferences On Synthetic Organic Chemistry 日期:2004 卷标:1 页码:1-5]
52816-02-1 = 830-96-6 反应条件:1.1 Reagents: Potassium Hydroxide,Hydrazine Hydrate (1:1) Solvents: Ethanol; < 20 °C; 4 H,Reflux 标题:Synthesis And Antitumor Properties Of Bis-Indole Derivatives 作者:Song,Binbin; Et Al 参考文献:Journal Of Chemical And Pharmaceutical Research 日期:2014 卷标:6(10) 页码:239-243
二乙基2-(1H-吲哚-3-基甲基)丙二酸酯置于氢氧化钾体系中,化学反应生成 3-吲哚丙酸 参考文献:Notes: Convenient Syntheses Of 3-Indolesuccinic And 3-Indolepropionic Acids 标题:Notes: Convenient Syntheses Of 3-Indolesuccinic And 3-Indolepropionic Acids 摘要: DOI:10.1021/jo01090A631
专利号:US-2002055171-A1 优先权日:1998-05-27 标题 :Preparation of biologically active 3-methyleneoxindole and definition of its application in stimulation of plant growth and tissue repair 发明人:TULI VIRENDA KUMAR 摘要:Identification of the true nature and metabolic action of 3 -methyleneoxindole (MO), a naturally occurring catabolite of the plant auxin, indole- 3 -acetic acid (IAA). Description of the two novel methods of synthesis of MO which produce the pure, biologically active auxin compound of MO. Discovery and description of the causes for the erroneous classification of MO as an inert compound with no auxin activity. These findings and methods of synthesis correct the ubiquitous theoretical errors which have driven scientific investigation and plant science research of plant auxins for nearly forty years. n Researchers have failed to observe the auxin activity of MO because of the use of standard but incorrect synthetic techniques which have consistently produced impure forms of 3 -bromooxindole- 3 -acetic acid ( 3 -Brox), the synthetic precursor of MO. In addition, the use of dimethylsulfooxide as a solvent for MO has been identified as a major source of contamination of MO during synthesis. n This invention describes two novel methods for synthesizing (MO). By using purified MO and avoiding the use of dimethylsulfoxide, it was found that the resulting MO product to be 100 to 1,00 fold more effective than IAA in promoting rooting in plant cuttings; supporting tissue differentiation and growth in stage I, stage II and stage III media used for the micropropagation of explants; promoting the formation of callus tissue over wounded plant parts; and, stimulating the production of interstitial tissue between scion and rootstock to increase the success rate for grafting. Therefore, this invention identifies MO as the dominant auxin in shoot acceleration, root development, wound sealing and scion acceptance. n Finally, the correct pathway from IAA to MO is presented.
专利号:US-9574189-B2 优先权日:2005-12-01 标题:Enzymatic encoding methods for efficient synthesis of large libraries 发明人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK 权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS 摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
专利号:EP-0609638-A1 优先权日:1992-10-27 标 题:Water soluble polymeric systems of phytohormones with slow release: synthesis and application 发明人:TSATSAKIS ARISTIDIS; VLACHAKIS ELEUTERIOS IOANIS; SHTILMAN ISAAK MICHAIL; SHASHKOVA MICHAIL IRINA; ALLAKHVERDIEV SURKHAI RAGIM IN 权利人:TSATSAKIS ARISTIDIS; VLACHAKIS ELEUTERIOS IOANIS; SHTILMAN ISAAK MICHAIL; SHASHKOVA MICHAIL IRINA; ALLAKHVERDIEV SURKHAI RAGIM IN 摘要:Our discovery concerns the method of synthesis and the application of new chemical products for plant growing. These new products are polymeric derivatives of low molecular weight plant growth regulators and are characterized by slow release of the auxin from the polymeric carrier. By copolymerisation of allylic esters of the low molecular weight auxins with the acrylic (or the methylacrylic) acid and the following modification of the synthesized co-polymers of acids to their corresponding ammonium salts, water soluble polymeric auxins possesing optimal molecular weight and desirable (high) content of the low molecular weight auxin in the polymer were prepared. The method of synthesis and the final products fulfill the requirements of the preparation technology and of their application respectively. We suggest the application of the new products in agronomy (i.e. treatment of seeds, rootstocks, plants, scions, cutting etc) either by themselves or by combination of them with other chemicals. The chemical structure of the new products we discover is :n n    R = H-, -CH3, Au = auxin residue
专利号:US-11078526-B2 优先权日:2016-02-11 标 题:Polyphenolic additives in sequencing by synthesis 发明人:OLEJNIK JERZY; Perbost Michel Georges 权利人:ISOPLEXIS CORP 摘要:The invention relates to methods, compositions, devices, systems and kits as described including, without limitation, reagents and mixtures for determining the identity of nucleic acids in nucleotide sequences using, for example, sequencing by synthesis methods. In particular, the present invention contemplates the use of polyphenolic compounds, known as antioxidant additives, to improve the efficiency of Sequencing-By-Synthesis reactions. For example, gallic acid (GA) is shown herein to be one of many exemplary SBS polyphenolic additives.
专利号:US-7390801-B2 优先权日:1996-12-23 标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds 发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J 权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI 摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-10036011-B2 优先权日:2016-02-11 标 题:Scavenger compounds for improved sequencing-by-synthesis 发明人:ANDRUZZI LUISA 权利人:QIAGEN WALTHAM INC 摘要:The present invention discloses methods of applications of indole-3-propionic acid, L-carnitine and O-acetyl-L-carnitine in one or more different reactive steps of a sequencing-by-synthesis workflow. The reactive steps employing these compounds include, but are not limited to, cleaving, imaging, incorporating bases and washing. The use of these new compounds provides improved sequencing performance including, but not limited to, lower error rates, higher sequence outputs and/or longer read lengths.
1: Köse M, Ritter K, Thiemke K, Gillard M, Kostenis E, Müller CE. Development of [(3)H]2-Carboxy-4,6-dichloro-1H-indole-3-propionic Acid ([(3)H]PSB-12150): A Useful Tool for Studying GPR17. ACS Med Chem Lett. 2014 Jan 16;5(4):326-30. doi: 10.1021/ml400399f. 2: Hwang IK, Yoo KY, Li H, Park OK, Lee CH, Choi JH, Jeong YG, Lee YL, Kim YM, Kwon YG, Won MH. Indole-3-propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus. J Neurosci Res. 2009 Jul;87(9):2126-37. doi: 10.1002/jnr.22030. doi: 10.1016/j.phytochem.2015.05.023. Review. doi: 10.1016/j.plaphy.2013.08.003. doi: 10.1038/srep29367. 12: Bosco R, Caser M, Vanara F, Scariot V. Development of a rapid LC-DAD/FLD method for the simultaneous determination of auxins and abscisic acid in plant extracts. J Agric Food Chem. 2013 Nov 20;61(46):10940-7. doi: 10.1021/jf4034305. doi: 10.1016/j.bbamem.2010.07.032.
合成参考文献
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