CAS: 76757-92-1; Boc-D-Tyr(Et)-Oh

上下游产品

CAS号64-67-5 硫酸二乙酯 | CAS号70642-86-3 B°C-D-酪氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号556-02-5 D-酪氨酸 | CAS号76757-90-9 丁氧羰基-D-酪氨酸-甲氧基酯 | CAS号3728-20-9 D-酪氨酸甲酯盐酸盐 | CAS号74-96-4 溴乙烷

丁氧羰基-D-酪氨酸-甲氧基酯置于sodium Hydroxide,18-冠醚-6,Potassium Carbonate体系中,用 甲醇,水,苯 作为反应溶剂,化学反应 2.0H,反应生成 N-叔丁氧羰基-O-乙基-D-酪氨酸
参考文献:A Convenient Method For O-Alkylation Of N-Substituted Tyrosines Using A Crown Ether
标题:A Convenient Method For O-Alkylation Of N-Substituted Tyrosines Using A Crown Ether
摘要:
DOI:10.1021/jo00322A049

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:WO-9834113-A1
优先权日:1997-02-04
标题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; HOUGHTEN RICHARD A; BLONDELLE SYLVIE E; SCHONER CHRISTA C
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:US-6359144-B1
优先权日:1997-02-04
标 题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A
权利人:LION BIOSCIENCE AG
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:WO-9811438-A1
优先权日:1996-09-13
标题 :Synthesis of quinazolinone libraries and derivatives thereof