CAS: 74003-63-7; 3-Methylquinoxaline-2-Carboxylic Acid
- 英文名称3-Methylquinoxaline-2-Carboxylic Acid
- 中文名称3-甲基-喹噁啉-2-羧酸
- IUPAC名称3-methylquinoxaline-2-carboxylic acid
- 其它别名3-Methylquinoxaline-2-Carboxylicacid; 3-Methyl-2-Quinoxalinecarboxylic Acid; 2-Quinoxalinecarboxylic Acid, 3-Methyl-
- CAS编号74003-63-7
- MFCD编号:MFCD03840415
- EINECS号:635-366-6
- 分子式:C10H8N2O2分子量:188.18
- 产品CID: 1728596
- 产品分类有机原料→分子砌块→芳杂环类化合物→喹噁啉类化合物
相似化合物
879-65-2 2244217-93-2 3885-38-9物理性质
- 熔点168-170°C
- 沸点347.1°C at 760 mmHg
- 闪点163.7°C
- 密度1.4±0.1 g/cm3
- pKa:2.37±0.30(预测)
- PSA:63.08
- LogP:1.63642
- 折射率1.673
- 蒸汽压0.0±0.8 mmHg at 25°C
- 溶解性DMF: 25 mg/mL; DMSO: 30 mg/mL; DMSO:Pbs (Ph 7.2) (1:10): 0.1 mg/mL; Ethanol: 25 mg/mL
- 外观形态棕色至深棕色固体
- 储存条件密封干燥,冷冻保存, 低于 -20°C
- 产品应用该化合物是基诺克酮或奥勒昆虫的关键的还原N-氧化代谢物,通过诱导S-阶段细胞循环逮捕有效抑制张的肝细胞生长.
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(经口)
特定目标器官毒性 - 单次接触 类别3
严重眼刺激 类别2
急性毒性 类别4(吸入)
急性毒性 类别4(经皮) - 警示词Warning(警告)
- 危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H319 |造成严重眼刺激.
H332 |吸入有害.
H312 |皮肤接触有害. - 防范说明P261-P264-P270-P271-P280-P304+P340-P330-P405-P501
- 危险等级IRRITANT
- UN编号NONH for all modes of transport
- 危险品标志Xi,Xn
- 安全声明26
- 危险类别码22-36/37
- WGK Germany3
欧盟法规
ECHA物质C&L通报上下游产品
CAS号61522-54-1 Methyl 3-methyl... | CAS号25519-55-5 3-甲基-2-喹喔啉甲醛 | CAS号2379-55-7 2,3-二甲基喹戊啉 | CAS号480-96-6 苯并氧化呋咱 | CAS号13297-18-2 2-(ETHOXYCARBON... | CAS号88-74-4 2-硝基苯胺 | CAS号3885-38-9 2-Methyl-3-etho... | CAS号24309-97-5 β-(N-乙酰乙酰氨基)乙醇-d4 | CAS号7446-08-4 二氧化硒 | CAS号108-38-3 间二甲苯合成工艺路线路线简述
- 合成目标产物 3-Methyl-Quinoxaline-2-Carboxylic Acid 主要起始原料 2-Quinoxalinecarboxylic Acid, 3-Methyl-, Methyl Ester
- (文献来源)合成步骤主要原料 2-Quinoxalinecarboxylic Acid, 3-Methyl-, Methyl Ester
📜3-甲基-2-喹喔啉甲醛置于potassium Permanganate,硫酸体系中,用 吡啶,水 作为反应溶剂,化学反应 24.0H,以66%的收率获得产物3-甲基-喹啉-2-甲酸
参考文献:Zur Oxydation Von 2,3-Dimethylchinoxalin Und 2,4-Dimethylchinazolin Mit Selendioxid
标题:Zur Oxydation Von 2,3-Dimethylchinoxalin Und 2,4-Dimethylchinazolin Mit Selendioxid
摘要:
DOI:10.1007/bf00808754
海关参考信息
- 2902200000-苯
2905110000-甲醇
2912110000-甲醛
2915110000-甲酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-4866175-A
优先权日:1966-11-08
标 题 :Novel process for the synthesis of quinoxaline and benzimidazole-N-oxides
发明人：ISSIDORIDES COSTAS H; HADDADIN MAKHLUF J
权利人:RESEARCH CORP
摘要:The synthesis of quinoxaline and benzimidazole-N-oxides and of ester amd amide derivatives of 3-hydroxy-2-quinoxalinecarboxylic acid by a movel process consisting of the reaction between a benzofuroxan and an activated methylene-containing compound under basic conditions.
专利号:US-3767657-A
优先权日:1971-03-31
标 题 :Process for the preparation of quinoxaline di n oxides
发明人：ROBERTSON R; KASUBICK R
权利人:PFIZER
摘要:IMPROVED SYNTHESIS OF ESTERS OF 2-QUINOXALINECARBOXYLIC ACID-1,4-DIOXIDES THROUGH A CONDENSATION OF A BENZOFUROXAN AND B-KETOESTER IN THE PRESENCE OF A CATALYTIC AMOUNT OF CALCIUM HYDROXIDE, AT A TEMPERATURE OF 40-80*C.
专利号:US-3763162-A
优先权日:1971-08-06
标 题 :Transesterification of quinoxaline-2-carboxylic acid esters
发明人：KASUBICK R
权利人:PFIZER
摘要:SYNTHESIS OF 2-HYDROXYETHYL ESTERS OF 2-QUINOXALINECARBOXYLIC ACID-1,4-DIOXIDES THROUGH THE TRANSESTERIFICATION OF THE LOWER ALKYL ESTERS WITH ETHYLENE GLYCOL IN THE PRESENCE OF OXYGEN AND A CATALYTIC AMOUNT OF CALCIUM HYDROXIDE OF BARIUM HYDROXIDE AT A TEMPERATURE OF 30-50*C.
专利号:US-4343942-A
优先权日:1966-11-08
标题:Quinoxaline derivatives
发明人：ISSIDORIDES COSTAS H; HADDADIN MAKHLUF J
权利人:RESEARCH CORP
摘要:The synthesis of quinoxaline and benzimidazole-N-oxides and of ester and amide derivatives of 3-hydroxy-2-quinoxalinecarboxylic acid by a novel process consisting of the reaction between a benzofuroxan and an activated methylene-containing compound under basic conditions.
专利号:CN-103420926-B
优先权日:2013-06-07
标题 :Chemical synthesis of four metabolites of quinocetone
专利号:CN-103420926-A
优先权日:2013-06-07
标题 :Chemical synthesis of four metabolites of quinocetone
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
[参考文献]: Keyu Zhang , Et Al. Cytotoxicity And Genotoxicity Of 1,4-Bisdesoxyquinocetone, 3-Methylquinoxaline-2-Carboxylic Acid (Mqca) In Human Hepatocytes. Res Vet Sci. 2012 Dec;93(3):1393-401.合成参考文献
参考文献:10.1007/978-3-031-42855-5_31
摘要:Papaneophytou C. Modern Applications in the Determination of Food and Feed Additives. 2023. In: Sustainable Use of Feed Additives in Livestock.
参考文献:10.1186/s44280-023-00032-w
摘要:Wang Y, Li Q, Liang G, Li H, Li Z, Gao T, Song L, Huang X, Peng D, Zhang X. Preparation of a highly specific and sensitive monoclonal antibody against tilmicosin and its application in lateral flow immunoassay. One Health Adv. 2023 Dec 29;1(1). doi: 10.1186/s44280-023-00032-w.
参考文献:10.1134/s1061934825701448
摘要:Zhedulov AE, Sorokin AV, Nekrasov DY, Mamedova EI, Batov IV. Determination of Carbadox, Cyadox, Mequindox, and Quinocetone Metabolites in Livestock Products by HPLC–MS/MS. J Anal Chem. 2026 Jan;81(1):127–38. doi: 10.1134/s1061934825701448.
参考文献:10.1093/jaoac/88.2.472
摘要:Huang L, Xiao A, Fan S, Yin J, Chen P, Liu D, Qiu Y, Wang Y, Yuan Z. Development of Liquid Chromatographic Methods for Determination of Quinocetone and Its Main Metabolites in Edible Tissues of Swine and Chicken. 2005 Mar 01;88(2):472–8. doi: 10.1093/jaoac/88.2.472.
参考文献:10.1016/j.foodchem.2016.04.083
摘要:Li G, Zhao L, Zhou F, Li J, Xing Y, Wang T, Zhou X, Ji B, Ren W. Monoclonal antibody production and indirect competitive enzyme-linked immunosorbent assay development of 3-methyl-quinoxaline-2-carboxylic acid based on novel haptens. Food Chem. 2016 Oct 15;209():279–85. doi: 10.1016/j.foodchem.2016.04.083.
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