CAS: 70362-41-3; 2,3,3',4,5'-Pentachlorobiphenyl

该化合物是多氯联苯(PCB)家族的成员,该家族由碳,氢和氯原子组成的合成有机化学品组成.PCB 108的特征是其双联结构,其中两个苯环由一个单一的联结连接在一起,在环上替换多个氯原子.具体地说,PC 108共有六个氯原子附着,影响其物理和化学特性.这种化合物一般是无色的,不光黄色固体或粘粘液,视温度而定.多氯联苯,包括PC 108,因其化学稳定性,疏水性和耐降解性而闻名,因此在各种工业应用中有用,如电器设备和热交换器.然而,由于其环境持久性和潜在的健康风险,包括致癌效应和内分泌干扰,许多国家已禁用或严格管制多氯联苯.多氯联苯108与其他多氯联苯一样,可以在食物链中进行生物蓄积,对野生生物和人类健康造成风险.

英文名称2,3,3',4,5'-Pentachlorobiphenyl
中文名称2,3,3',4,5'-五氯联苯
IUPAC名称1,2,3-trichloro-4-(3,5-dichlorophenyl)benzene
其它别名2,3,3',4,5'-Pentachlorobiphenyl; 2,3,4,3',5'-Pentachlorobiphenyl
CAS编号70362-41-3
MFCD编号:MFCD00152719
EINECS号:690-318-1
FDA UNII编号:HGU9K3BW0U
分子式:C12H5Cl5分子量:326.43
产品CID: 1697628
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: MPCDNZSLJWJDNW-UHFFFAOYSA-N
InChI=1S/C12H5Cl5/c13-7-3-6(4-8(14)5-7)9-1-2-10(15)12(17)11(9)16/h1-5H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS08 & GHS09;
注释: Health hazard & Environment
危险类别致癌性类别2
特定目标器官毒性-重复接触类别2
水生慢性毒性类别1
警示词Warning(警告)
危险描述H351 |怀疑致癌.
H373 |长期或反复接触可能损害器官.
H410 |对水生生物毒性极大并具有长期持续影响.
防范说明P203, P260, P273, P280, P318, P319, P391, P405, and P501
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

欧盟法规

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上下游产品

1,2,3-trichloro-4-iodobenzene 3,5-dichloroiodobenzene

合成工艺路线路线简述

📜2,3,4-三氯碘苯,3,5-二氯碘苯置于铜体系中,用 N,N-二甲基甲酰胺作为反应溶剂,化学反应生成 2,3,3',4,5'-五氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4