十一烷酸置于盐酸,Amalgamated Zinc,硫酸,Sodium Ethanolate体系中,115.0~120.0 °C,2.67 Kpa 条件下,反应生成 正二十一烷 参考文献:Strating; Backer,Recueil Des Travaux Chimiques Des Pays-Bas,1936,Vol. 55,P. 903,914 标题:Strating; Backer,Recueil Des Travaux Chimiques Des Pays-Bas,1936,Vol. 55,P. 903,914
专利号:US-7230101-B1 优先权日:2002-08-28 标 题:Synthesis of methotrexate-containing heterodimeric molecules 发明人:MURTHI KRISHNA K; SMITH CHASE C 权利人:GPC BIOTECH INC 摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:
专利号:US-11655264-B2 优先权日:2015-11-25 标题:Metallocene compounds, and preparation and use thereof for synthesis of poly-alpha-olefins as lubricating base oil 发明人:WEI DONGCHU; LI BING 权利人:APALENE TECH CO LTD JIAXING 摘要:The present invention relates to a metallocene compound, and preparation and use thereof, and the compound can be used as a catalyst for synthesis of poly-α-olefin as lubricating base oil. The metallocene compound includes a substituted aryl group, a bridged atom, an optionally unsubstituted, 3-mono-substituted or 3,6-disubstituted 5H-indeno [1,2-b] pyridyl group or optionally unsubstituted, 3-mono-substituted or 3,6-disubstituted 5H-indeno [1,2-b] thiopyranyl group, and a metal coordination group. As a catalyst, the metallocene compound is shown to be structurally stable and high in catalytic efficiency, and the preparation of the catalyst is relatively easy in operation, high in yield, low in cost, low in pollution and easy to scale up for industrial production.
专利号:US-7598291-B2 优先权日:2004-09-02 标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-2010160244-A1 优先权日:2004-09-02 标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-2013095043-A1 优先权日:2010-06-29 标题 :Synthesis of high-performance iron oxide particle tracers for magnetic particle imaging (mpi) 发明人:BURDINSKI DIRK; BOHLENDER CARMEN; HAEX NICOLE P M 权利人:BURDINSKI DIRK; BOHLENDER CARMEN; HAEX NICOLE P M; KONINKL PHILIPS ELECTRONICS NV 摘要:The present invention relates to a method of forming iron oxide nanoparticles comprising the steps of (a) suspending iron oxide/hydroxide and oleic acid or a derivative thereof in a primary organic solvent; (b) increasing the temperature of the suspension by a defined rate up to a maximum of 340° C. to 500° C.; (c) aging the suspension at the maximum temperature of step (b) for about 0.5 to 6 h; (d) cooling the suspension; (e) adding a secondary organic solvent; (f) precipitating nanoparticles by adding a non-solvent and removing excess solvent; (g) dispersing said nanoparticles in said secondary organic solvent; (h) mixing the dispersion of step (g) with a solution of a polymer; and (i) optionally removing said secondary organic solvent. The present invention further relates to an iron oxide nanoparticle obtainable by the method, the additional modification, encapsulation and decoration of such nanoparticles, as well as the use of the nanoparticles as tracers for Magnetic Particle Imaging (MPI), Magnetic Particle Spectroscopy (MPS).
专利号:US-9944869-B2 优先权日:2007-03-08 标 题 :Synthesis of liquid fuels and chemicals from oxygenated hydrocarbons 发明人:CORTRIGHT RANDY D; BLOMMEL PAUL G 权利人:VIRENT INC 摘要:Processes and reactor systems are provided for the conversion of oxygenated hydrocarbons to hydrocarbons, ketones and alcohols useful as liquid fuels, such as gasoline, jet fuel or diesel fuel, and industrial chemicals. The process involves the conversion of mono-oxygenated hydrocarbons to aromatics and gasoline range hydrocarbons where the oxygenated hydrocarbons are derived from biomass.
参考标题:Addition Of Organocerium Reagents To Morpholine Amides: Synthesis Of Important Pheromone Components Of Achaea JAnata 作者:Michele Badioli,Roberto Ballini,Massimo Bartolacci,Giovanna Bosica,Elisabetta Torregiani,Enrico Marcantoni |发布日期:2002.12.1 摘要:Produce Ketones. Even In The Presence Of Substrates And Reagents With High Steric Hindrance, The Organometallic Compounds Prepared From Dry Cerium(III) Chloride And Organomagnesium Or Organolithium Compounds At -78 Degrees C Add Cleanly To Morpholine Amides. The Low Cost Of Starting Materials Makes This New Scheme Of Synthesis Very Interesting For The Preparation Of Biologically Important Pheromones.
合成参考文献
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