CAS: 5950-34-5; Methyl Aziridine-2-Carboxylate

该化合物是一种反应性很强的丙烯衍生物,其特点是其三人组成的环形结构和酯功能紧张,该化合物在有机合成中起着多用途中间作用,特别是在准备氨基酸,酸和其他含氮的乙型环状循环过程中.其紧张的环状系统有利于环状开关反应,在温带条件下能够有选择地发挥作用.甲基酯组增加了各种溶性,提高了各种溶剂的再活性,使之适合核分裂和电极变异.由于它的活性,它常常被用于制药和农用化学研究,以构建复杂的分子框架.由于它在某些条件下的潜在毒性和不稳定性,适当的处理是必不可少的.

结构式图片

相似化合物

75154-68-6 181212-90-8 160233-42-1

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号1729-67-5 2,3-二溴丙酸甲酯 | CAS号76357-18-1 1-(三苯基甲基)-2-氮丙啶羧酸甲酯 | CAS号181212-90-8 1-叔丁基 2-甲基 氮丙啶-... | CAS号76357-18-1 1-(三苯基甲基)-2-氮丙啶羧酸甲酯 | CAS号103539-32-8 (r)-氮丙啶-2-羧酸甲酯 | CAS号67008-13-3 aziridine-2-car... | CAS号82912-42-3 2-Aziridinecarb... | CAS号86106-96-9 methyl 1-(3-met... | CAS号88419-36-7 aziridin-2-ylme...

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    专利信息


    专利号:US-2023039836-A1
    优先权日:2020-01-10
    标 题:Aromatic sulphonamides derivatives that inhibits pdi a3, their synthesis and use
    发明人：KALVINS IVARS; CHLOPICKI STEFAN; STOJAK MARTA; ANDRIANOV VICTOR; DOMRACEVA ILONA; KANEPE-LAPSA IVETA; ZELENCOVA DIANA; WIETRZYK JOANNA; TURLEJ ELIZA; STACHOWICZ MARTYNA; JAROSZ JOANNA; MILCZAREK MAGDALENA; KRAMKOWSKI KAROL
    权利人:UNIV JAGIELLONSKI
    摘要:The invention relates to a new group of aromatic sulphonamides derivatives of formula (I) and their synthesis and use for modulation of the activity of protein disulfide isomerase (PDI). More particularly, the invention provides small molecule inhibitors of PDI A1 that display antiplatelet, antithrombotic and anticancer activities.

    专利号:US-2023069886-A1
    优先权日:2020-01-10
    标 题 :Aromatic sulphonamides derivatives that inhibits pdi a3, their synthesis and use
    发明人：CHLOPICKI STEFAN; KALVINS IVARS; PRZYBOROWSKI KAMIL; STOJAK MARTA; ANDRIANOV VICTOR; DOMRACEVA ILONA; KANEPE-LAPSA IVETA; ZELENCOVA DIANA; WIETRZYK JOANNA; TURLEJ ELIZA; STACHOWICZ MARTYNA; JAROSZ JOANNA; MILCZAREK MAGDALENA; KRAMKOWSKI KAROL
    权利人:UNIV JAGIELLONSKI
    摘要:The invention relates to a new group of aromatic sulphonamides derivatives of formula (I) and their synthesis and use for modulation of the activity of protein disulfide isomerase (PDI). More particularly, the invention provides small molecule inhibitors of PDI A3 that display antiplatelet, antithrombotic and anticancer activities.

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    合成参考文献


    摘要:Ochoa, C. I.; Tambar, U. K., Science of Synthesis Knowledge Updates, (2020) 2, 354.
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