CAS: 580-17-6; 3-Aminoquinoline

该化合物是一种有机化合物,其特征为肾脏结构,其基质组位于环中第三个碳点,它看起来像黄色到褐色的固体,以其芳香特性而著称,有助于其稳定性和反应性.氨基质组的存在增强了其氢联结的潜力,使其成为有机合成的多功能中间体.3-Aminoquinoline在水和酒精等极地溶剂中溶解,而在非极溶剂中溶解较少.该复合体展示了生物活动,包括抗微生物和抗震特性,使其对药用化学感兴趣.此外,它可以参与各种化学反应,例如电益替代和混合反应,这些反应在合成更复杂的分子中很有价值.安全数据表明,应当谨慎地处理,因为接触时可能会对健康造成危害.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号5332-24-1 3-溴喹啉 | CAS号204773-13-7 N-allyl-3-quino... | CAS号79476-07-6 3-碘喹啉 | CAS号14213-02-6 3-azidoquinoline | CAS号7433-86-5 3-Nitro-quinoli... | CAS号17576-53-3 3-硝基喹啉 | CAS号132521-66-5 2,4-二氯-3-硝基喹啉 | CAS号529-23-7 邻氨基苯甲醛 | CAS号75-08-1 乙硫醇 | CAS号109029-20-1 3-isothi°Cyanat... | CAS号109543-48-8 3-amino-1H-quin... | CAS号612-59-9 3-氯喹啉 | CAS号396-31-6 3-氟喹啉 | CAS号143667-62-3 2-methyl-4H-[1,... | CAS号143667-61-2 2-氨基噻唑并[4,5-C]喹啉 | CAS号171364-85-5 喹啉-3-硼酸频哪醇酯 | CAS号40615-02-9 1,2,3,4-四氢喹啉-3-胺 | CAS号230-10-4 benzo[f][1,7]na... | CAS号25199-76-2 3-(三氟甲基)喹啉

合成工艺路线路线简述

    3-溴喹啉置于4,4'-二甲基-2,2'-联吡啶,碳酸氢铵,Nickel Diacetate,1,8-二氮杂双环[5.4.0]十一碳-7-烯,Potassium Bromide体系中,用 四氢呋喃,N,N-二甲基乙酰胺 作为反应溶剂,以61 %的收率获得产物3-氨基喹啉
    参考文献:Ni 催化芳基卤化物与铵盐偶联光化学合成苯胺
    标题:Ni 催化芳基卤化物与铵盐偶联光化学合成苯胺
    摘要:简单,高效和经济地合成苯胺仍然是合成化学中的一个重要挑战.在这项研究中,Ni(Oac) 2-联吡啶络合物表明在光的直接激发下很容易催化芳基卤化物与铵盐的胺化反应,从而使多种芳基氯和溴转化为相应的伯(杂) 在没有外部光敏剂的情况下的芳基胺.药物分子的后期修饰和伯芳基胺的15 N-标记也通过许多示例进行了演示.光诱导产生 Ni(I)-联吡啶物种被认为是反应中的关键步骤,使 Ni(I)/ni(Iii) 循环能够进行催化转换.
    DOI:10.1021/acscatal.2C04959

    海关参考信息

    专利信息


    专利号:EP-0310950-B1
    优先权日:1983-11-18
    标题 :Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes
    摘要:Compounds of the types (I) and (II) are disclosed, wherein each R5 is independently selected from the group consisting of alkyl of one to about four carbon atoms, alkoxy of one to about four carbon atoms and halogen, and n is an integer from 0 to 2, with the proviso that if n is 2, then said R5 substituents together contain no more than 6 carbon atoms; R6 is selected from the group consisting of hydroxyalkyl of one to about six carbon atoms and cyclohexylmethyl; and R7 is selected from the group consisting of alkyl of one to about four carbon atoms and hydrogen. These compounds may be used as intermediates for the synthesis of 1H-imidazo[4,5-c]quinoline derivatives.

    专利号:WO-2024134682-A1
    优先权日:2022-12-21
    标题:(n-alkyldihydrol-2h-oxazinyl)-cannabidiol as anti-proliferative agent and process for preparation thereof
    发明人：CHAM PANKAJ SINGH; SINGH AJEET; JAMWAL ASHIYA; SINGH RATTANDEEP; - SHABU; THAPA SONIA; WAZIR PRIYA; NANDI UTPAL; SINGH SHASHANK KUMAR; SINGH PARVINDER PAL
    权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S
    摘要:The present invention relates to ring annulated analogues of cannabidiol where either one or both sides of the aromatic ring are attached to the oxazinyl ring, their method of preparation and use as anti-proliferative agents. The present invention provides a ring annulated cannabidiol analogue compound of Formula I. The present invention further provides a process for the synthesis of ring annulated cannabidiol analogue compound of Formula I.

    专利号:US-6495693-B2
    优先权日:1996-11-22
    标题:N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
    发明人：AUDIA JAMES E; FOLMER BEVERLY K; JOHN VARGHESE; LATIMER LEE H; NISSEN JEFFREY S; PORTER WARREN J; THORSETT EUGENE D; WU JING
    权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
    摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

    专利号:US-7504409-B2
    优先权日:2000-01-31
    标 题:Mucin synthesis inhibitors
    发明人：ZHOU YUHONG; LEVITT ROY C; NICOLAIDES NICHOLAS C; JONES STEVE; MCLANE MIKE
    权利人:GENAERA CORP
    摘要:The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and chronic bronchitis, inflammatory lung diseases, cystic fibrosis and acute or chronic respiratory infectious diseases.

    专利号:US-7345051-B2
    优先权日:2000-01-31
    标题 :Mucin synthesis inhibitors
    发明人：ZHOU YUHONG; LEVITT ROY C; NICOLAIDES NICHOLAS C; JONES STEVE; MCLANE MIKE
    权利人:GENAERA CORP
    摘要:The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds of Formula II in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and chronic bronchitis, inflammatory lung diseases, cystic fibrosis and acute or chronic respiratory infectious diseases. n nwhereinn X is S, N, O or CR; Y is CRR′, O, NR 6 , CRR′—CRR′ or CRâ•?CR; Z is NR 6 , O, S, CRR′ or CRR′—CRR′; R 1 -R 3 are independently selected from the group consisting of H, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, amino, hydroxy, halosubstituted alky and halo; R 4 is n n n n n n n n n n n n n n n n n n n Q is CR, NR 6 or n n n n n n n n n n n n R 5 is H or benzyl; n R 6 is H, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, OH or halo; and n R and R′ are independently H, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, OH or halo,n nor a harmaceutically acceptable salt thereof.

    专利号:US-2002147216-A1
    优先权日:2000-01-31
    标 题:Mucin synthesis inhibitors
    发明人：ZHOU YUHONG; LEVITT ROY C; NICOLAIDES NICHOLAS C; JONES STEPHEN; MCLANE MIKE
    摘要:The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and chronic bronchitis, inflammatory lung diseases, cystic fibrosis and acute or chronic respiratory infectious diseases.

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    合成参考文献


    摘要:J. J. Elliott and S. F. Mason. J. Chem. Soc. 1959, 2352.
    参考文献:10.1063/1.2232199
    摘要:Panda D, Datta A. The role of the ring nitrogen and the amino group in the solvent dependence of the excited-state dynamics of 3-aminoquinoline. J Chem Phys. 2006 Aug 07;125(5):054513. doi: 10.1063/1.2232199.
    参考文献:10.1155/2009/530639
    摘要:Borromei C, Careri M, Cavazza A, Corradini C, Elviri L, Mangia A, Merusi C. Evaluation of Fructooligosaccharides and Inulins as Potentially Health Benefiting Food Ingredients by HPAEC‐PED and MALDI‐TOF MS. International Journal of Analytical Chemistry. 2009 Jan;2009(1). doi: 10.1155/2009/530639.
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