CAS: 5521-57-3; 5-Methylpyrazine-2-Carboxamide

相似化合物

98006-91-8 132664-85-8 98-96-4

上下游产品

2-methylpyrazin-5-carboxylic acid 2,5-dimethyl-pyrazine 5-methylpyrazine-2-carboxylic acid methyl ester 3-carboxamido-2-hydroxy-6-methylpyrazine 5-methylpyrazin-2-amine acipimox 2-bromo-5-methyl-pyrazine

📜3-氯-5-甲基吡嗪-2-甲腈置于sodium Hydroxide Monohydrate,5%-Palladium/activated Carbon,氢气,双氧水,三乙胺体系中,用 甲醇,水 作为反应溶剂,20.0~100.0 °C,2.0 Mpa 条件下,反应 11.0H,反应生成 5-甲基吡嗪-2-羧酰胺
参考文献:一种2-氨基-5-甲基吡嗪的制备方法及产品与应用
标题:一种2-氨基-5-甲基吡嗪的制备方法及产品与应用
摘要:本发明属于化工合成领域,涉及一种2‑氨基‑5‑甲基吡嗪的制备方法及产品与应用,包括:使2‑氨基丙二酰胺和丙酮醛反应,反应生成2‑甲基‑5‑羟基‑4吡嗪酰胺;所述2‑甲基‑5‑羟基‑4吡嗪酰胺与三氯氧磷反应,反应生成2‑甲基‑5‑氯‑4‑氰基吡嗪;所述2‑甲基‑5‑氯‑4‑氰基吡嗪进行加氢反应,反应生成2‑甲基‑4‑氰基吡嗪,水解得到2‑甲基‑4‑酰胺吡嗪;所述2‑甲基‑4‑酰胺吡嗪经霍夫曼降解,得到2‑甲基‑5‑氨基吡嗪.该方法属于全新的2‑氨基‑5‑甲基吡嗪制备方法,操作简便,收率高,成本低廉,并且适合工业化放大生产.

专利信息

专利号:US-2023160018-A1
优先权日:2020-04-16
标 题 :Crybetab2 predicts poor breast cancer outcome and sensitizes tumors to nucleolin and cdk inhibition
发明人：MERINO VANESSA FERREIRA; POMPER MARTIN; SUKUMAR SARASWATI
权利人:UNIV JOHNS HOPKINS
摘要:CKYPB2 induces EMT, sternness, protein synthesis and cell cycle progression through regulation of nucleolin, con-tributing to an increase in tumor growth and metastasis. CKYPB2 can be used as a prognostic marker in African American women with TNBC. CKYPB2 can further select patients with TNBC and ER positive tumors that will likely benefit from inhibitors of ribosomal RNA synthesis, CDK4 and nucleolin.

专利号:US-2025270214-A1
优先权日:2022-04-22
标 题 :Method for producing 7h-pyrrolo[2,3-d]pyrimidine-4-amine derivative
发明人：TAKEDA DAISUKE; NONOSHITA KATSUMASA; KOBAYAKAWA Yu
权利人:TAIHO PHARMACEUTICAL CO LTD
摘要:The present invention provides a method for producing a compound represented by formula (I) suitable for mass synthesis as API. Provided according to one aspect of the present invention is a method for producing a compound represented by formula (I) or a salt thereof, the method including deprotecting a protecting group represented by R 1 in formula (II) under basic conditions to thereby form a compound represented by formula (I) or a salt thereof.

专利号:US-12233062-B2
优先权日:2018-09-26
标 题 :Heterocyclic derivatives useful as SHP2 inhibitors
发明人：HAN HUIFENG; GAO PANLIANG; MA CUNBO; KANG DI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:This invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention provides a pharmaceutical composition comprising the said compound.

专利号:MX-PA04005862-A
优先权日:2001-12-20
标 题 :SELECTED ANTAGONIST COMPOUNDS OF PYRIMIDINE A2B, ITS SYNTHESIS AND USE.