专利号:WO-2025125573-A1 优先权日:2023-12-14 标 题 :Manufacture of alpha, beta, gamma, delta or beta, gamma, delta di-unsaturated ketones carrying a terminal carboxyl group 发明人:AQUINO FABRICE; BONRATH WERNER; GOETZINGER ALISSA; HAESS STEFAN; LEHMANN HAJO; MEDLOCK JONATHAN ALAN; PACE FRANCESCO; SORIANO DOMENICO; STEMMLER RENÉ TOBIAS 权利人:DSM IP ASSETS BV 摘要:The present invention relates to synthesis of carboxy group terminated di-unsaturated ketones having C=C double bonds at the α,β and γ,δ position or at the β,γ and γ,δ position relative to the carbonyl carbon atom. These ketones can be obtained easily and in few steps from respective alkynols having a terminal carboxyl group. These ketones are important key building block for the synthesis of derivatives of isoprenoids, especially of vitamin E.
专利号:WO-2025125574-A1 优先权日:2023-12-14 标 题 :Manufacture of allylic alcohols carrying a terminal carboxyl group via ethynylation and lindlar hydrogenation 发明人:AQUINO FABRICE; BONRATH WERNER; GOETZINGER ALISSA; HAESS STEFAN; LEHMANN HAJO; MEDLOCK JONATHAN ALAN; PACE FRANCESCO; SORIANO DOMENICO; STEMMLER RENÉ TOBIAS 权利人:DSM IP ASSETS BV 摘要:The present invention relates to synthesis of specific allylic alcohols having terminal carboxyl groups based on steps of ethynylation and hydrogenation in the presence of a Lindlar catalyst. These allylic alcohols are particularly useful to offer pathways to syntheses of isophytol or tocopherols having a terminal carboxyl group by a very small number of reactions steps.
专利号:US-2022048879-A1 优先权日:2020-08-13 标 题:Synthesis of small molecules inspired by Phomoxanthone A 发明人:ALI RAMEEZ; MATTSON ANITA 权利人:WORCESTER POLYTECH INST 摘要:Methods, compositions, and kits are provided for synthesizing bioactive chromane, the method including: constructing a tertiary ether stereocenter enantioselectively by catalyzed alkynylation of a substituted chromenone to obtain a chromanone; reducing alkyne and ketone in the chromanone to obtain a chroman; and converting ester to methyl group thereby obtaining chromane.
专利号:US-8829238-B2 优先权日:2011-09-22 标 题:Methods for the synthesis of deuterated acrylate salts 发明人:YANG JUN; BONNESEN PETER V; HONG KUNLUN 权利人:YANG JUN; BONNESEN PETER V; HONG KUNLUN; UT BATTELLE LLC 摘要:A method for synthesizing a deuterated acrylate of the Formula (1), the method comprising: (i) deuterating a propiolate compound of Formula (2) to a methyne-deuterated propiolate compound of Formula (3) in the presence of a base and D 2 O: and (ii) reductively deuterating the methyne-deuterated propiolate compound of Formula (3) in a reaction solvent in the presence of deuterium gas and a palladium-containing catalyst to afford the deuterated acrylate of the Formula (1). The resulting deuterated acrylate compounds, derivatives thereof, and polymers derived therefrom are also described.
专利号:US-7074932-B2 优先权日:1999-06-24 标题 :Preparation of quinoline-substituted carbonate and carbamate derivatives 发明人:ALLEN MICHAEL S; PREMCHANDRAN RAMIYA H; CHANG SOU-JEN; CONDON STEPHEN; DEMATTEI JOHN A; KING STEVEN A; KOLACZKOWSKI LAWRENCE; MANNA SUKUMAR; NICHOLS PAUL J; PATEL HEMANT H; PATEL SUBHASH R; PLATA DANIEL J; STONER ERIC J; TIEN JIEN-HEH J; WITTENBERGER STEVEN J 权利人:ALLEN MICHAEL S; PREMCHANDRAN RAMIYA H; CHANG SOU-JEN; CONDON STEPHEN; DEMATTEI JOHN A; KING STEVEN A; KOLACZKOWSKI LAWRENCE; MANNA SUKUMAR; NICHOLS PAUL J; PATEL HEMANT H; PATEL SUBHASH R; PLATA DANIEL J; STONER ERIC J; TIEN JIEN-HEH J; WITTENBERGER STEVEN J 摘要:The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
专利号:US-2009111737-A1 优先权日:1999-05-24 标题:Novel antibacterial agents 发明人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
[参考文献]: Liuchun Yang, Et Al. Imaging Of The Intracellular Topography Of Copper With A Fluorescent Sensor And By Synchrotron X-Ray Fluorescence Microscopy. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11179-84.
合成参考文献
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118