CAS: 5222-73-1; 3,4-Dimethoxy-3-Cyclobutene-1,2-Dione

相似化合物

61699-62-5 5231-87-8 2892-62-8

上下游产品

CAS号122-51-0 原甲酸三乙酯 | CAS号2892-51-5 方酸 | CAS号149-73-5 原甲酸三甲酯 | CAS号80-11-5 N-甲基-N-亚硝基对甲苯磺酰胺 | CAS号67-56-1 甲醇 | CAS号1027429-37-3 2,3-Dimethoxy-4... | CAS号61699-62-5 方酸二异丙酯 | CAS号5231-87-8 方酸二乙酯 | CAS号1007834-23-2 2,3-dimethoxy-1... | CAS号156266-61-4 3,4,4-trimethox... | CAS号112597-30-5 4-hydroxy-2,3-d... | CAS号113976-71-9 4-hydroxy-2,3-d... | CAS号124022-02-2 3-ethenyl-4-met... | CAS号63649-29-6 3-甲氧基-4-(甲氨基)环丁...

方酸置于原甲酸三甲酯体系中,用 甲醇 作为反应溶剂,化学反应生成 3,4-二甲氧基-3-环丁烯-1,2-二酮
参考文献:环丁烯胺的新合成和扩环反应
标题:环丁烯胺的新合成和扩环反应
摘要:据报道,具有n-(杂)芳基取代的亚氨基环丁烯酮的合成有两种途径:以环丁二烯为起始的加成/取代序列和aza-Wittig方法.还提出了合成n-烷基衍生物的新途径.这涉及使用meerwein试剂对3-烷基氨基-1,2-环丁二烯进行o-烷基化,然后在非水解条件下进行去质子化.发现锂有机基团加到剩余的羰基上.反应生成的叔醇在二甲苯中加热后进行扩环反应,分别从4-乙烯基,4-芳基和4-炔基衍生物得到4-氨基苯酚,4-氨基-1-萘酚或环戊基环化的喹啉.
DOI:10.1071/ch10318

专利信息

专利号:WO-2016005407-A1
优先权日:2014-07-07
标 题:One-pot synthesis of squaramides
发明人：MÃ?RQUEZ LÓPEZ MARÃ?A EUGENIA; ALEGRE REQUENA JUAN VICENTE; PÉREZ HERRERA RAQUEL
权利人:UNIV ZARAGOZA; CONSEJO SUPERIOR INVESTIGACION
摘要:The present invention refers to the first one-pot synthesis of squaramides. The one-pot synthesis of squaramides described herein is an easy and straightforward procedure to obtain squaramide derivatives which saves energy, avoids time consuming purification steps, reduces costs and provides better yields as compared with those squaramides obtained through the traditional 'stop-and-go' approach. Moreover, the authors of the present invention herein demonstrate the efficiency of this one-pot process with the synthesis of three biologically active structures, improving in most of the cases the results of the previous stepwise syntheses.

专利号:US-8519168-B2
优先权日:2007-07-03
标 题 :Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
发明人：FU XIAOYONG; GUENTER FRANK BRUNO; KIM-MEADE AGNES S; MATTHEWS KENNETH STANLEY; MAUST MATHEW THOMAS; MCALLISTER TIMOTHY L; WERNE GERALD; WINTERS JASON L; YIN JIANGUO; ZHANG SHUYI
权利人:FU XIAOYONG; GUENTER FRANK BRUNO; KIM-MEADE AGNES S; MATTHEWS KENNETH STANLEY; MAUST MATHEW THOMAS; WERNE GERALD; WINTERS JASON L; YIN JIANGUO; ZHANG SHUYI; MOLOZNIK DAVID J; MERCK SHARP & DOHME
摘要:This application discloses a novel process for the preparation of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds, which have utility, for example, in the treatment of CXC chemokine-mediated diseases, and intermediates useful in the synthesis thereof.

专利号:PL-235827-B1
优先权日:2015-12-08
标题 :Synthesis of polyacrylamide derivative and its application

专利号:PL-231550-B1
优先权日:2015-12-08
标 题:Synthesis of amphiphilic polysaccharide derivative and its application

专利号:US-2011160469-A1
优先权日:2007-07-03
标 题:Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds

专利号:JP-2007077043-A
优先权日:2005-09-12
标题 :Pyrophosphoric acid analog and method for synthesis of pyrophosphoric acid analog