CAS: 50709-35-8; (2,5-Dichlorophenyl)Hydrazine Hydrochloride

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CAS号95-82-9 2,5-二氯苯胺 | CAS号89-61-2 2,5-二氯硝基苯

2,5-二氯苯胺置于盐酸,Tin(II) Chloride Dihdyrate,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应生成 2,5-二氯苯肼盐酸盐
参考文献:基于 3D-Qsar 的分子设计发现超高活性 N-苯基吡唑作为候选杀虫剂
标题:基于 3D-Qsar 的分子设计发现超高活性 N-苯基吡唑作为候选杀虫剂
摘要:三维定量构效关系(3D-Qsar)是指导新农药开发中分子设计的最重要和最有效的工具之一.chlorantraniliprole 是一种邻氨基苯甲酸二酰胺兰尼碱受体 (Ryr) 激动剂,具有超高活性,高选择性和哺乳动物安全性.为了继续我们对新杀虫剂开发的研究,在这里,我们以氯虫苯甲酰胺类似物的 3D-Qsar 为指导,设计了新的杀虫剂n-苯基吡唑.大多数合成的目标化合物对mythimna Separata,Plutella Xylostella和spodoptera Frugiperda表现出中等到极好的活性.化合物iii B和iii Y对m. Separata显示出与氯虫苯甲酰胺相似的活性(lc 50值:分别为 0.21,0.25 和 0.16 μg Ml-1).化合物iii B对小菜蛾的效力比氯虫苯甲酰胺高 3 倍.对于s. Frugiperda,Iii A和iii B的效力分别比阳性对照高
DOI:10.1021/acs.Jafc.2C08719

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:WO-2024012791-A1
优先权日:2022-07-11
标题 :Electrochemical synthesis of pyrazolines and pyrazoles
发明人：BÄR ROBIN MAXIMILIAN; FORD MARK JAMES; KALDAS SHERIF JAMES; WALDVOGEL SIEGFRIED; HOFMANN SILJA; LINDEN MARTIN
权利人:BAYER AG
摘要:The present invention relates to an electrochemical process for the synthesis of pyrazolines and pyrazoles of formula (I). The process can be especially used for the synthesis of the herbicide safener mefenpyr-diethyl.

专利号:EP-4555128-A1
优先权日:2022-07-11
标 题 :Electrochemical synthesis of pyrazolines and pyrazoles

专利号:US-2019152896-A1
优先权日:2016-07-27
标题 :Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts

专利号:TW-202406897-A
优先权日:2022-07-11
标题 :Electrochemical synthesis of pyrazolines and pyrazoles

专利号:CN-107663161-B
优先权日:2016-07-27
标题:A kind of continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt