CAS: 502-56-7; Nonan-5-One

该化合物是分子式C9H18O的一酮,其特点是九碳链和一个碳基组,位于第5位.这一清晰而无色液体的沸点大约为186-188°C和温和的氯酸盐味.它在水中容易溶解,但与大多数有机溶剂不相容. 5-Nonoone通常被用作有机合成的中间体,特别是在香气,口味和药品的生产中.其稳定的结构和可预测的再活动使其成为一个基于氯酮的反应的有价值的建筑块,包括Grignard的添加和减少.该化合物还被用于需要中链的脂质板的研究应用.

结构式图片

相似化合物

623-93-8 45206-91-5 540-08-9

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号623-93-8 5-壬醇 | CAS号108-29-2 丙位戊内酯 | CAS号1262219-77-1 5-oxononyl diph... | CAS号17774-02-6 4-bromobutylmercury | CAS号20615-03-6 bis-(1-butyl-pe... | CAS号91658-09-2 1-Pyrrolidinami... | CAS号1112990-01-8 5-oxononyl 4-me... | CAS号35900-26-6 4-甲基-5-壬酮 | CAS号33933-78-7 5-甲基-5-壬醇 | CAS号14570-43-5 2-propylindene-... | CAS号14475-42-4 5-Nonanone, oxime | CAS号16002-93-0 反式-1-苯基-1-戊烯 | CAS号109-52-4 正戊酸 | CAS号81392-97-4 (E)-1-(4-methyl... | CAS号2272-57-3 (E)-1-(3-chloro...

合成工艺路线路线简述

  • 合成目标产物 5-Nonanone 主要起始原料 γ-Valerolactone
  • (文献来源)合成步骤主要原料 γ-Valerolactone
三丁基硼置于sodium Hydroxide,正丁基锂,4,4-二甲基-2-氧唑啉,四甲基乙二胺,双氧水,碘甲烷体系中,化学反应生成 5-壬酮
参考文献:Baba,Tsutomu; Suzuki,Akira,Synthetic Communications,1983,Vol. 13,# 5,P. 367-372
标题:Baba,Tsutomu; Suzuki,Akira,Synthetic Communications,1983,Vol. 13,# 5,P. 367-372

海关参考信息

专利信息


专利号:US-2024158926-A1
优先权日:2022-11-03
标 题 :Electrochemical synthesis of hydroxyvaleric acid from levulinic acid
发明人:HOLEWINSKI ADAM; DE SOUZA LUCAS FRANCISCO WILLIAN
权利人:UNIV COLORADO REGENTS
摘要:Disclosed herein are methods of electrochemical synthesis of hydroxyvaleric acid from levulinic acid. For example, disclosed herein are methods comprising electrochemical synthesis of hydroxyvaleric acid from levulinic acid, wherein the method is conducted in an electrochemical cell wherein a working electrode is in electrochemical contact with an aqueous electrolyte and levulinic acid, wherein the method comprises applying a potential to electrochemically reduce the levulinic acid to form hydroxyvaleric acid. Also disclosed herein are methods of synthesizing gamma-valerolactone from hydroxyvaleric acid, the method comprising acid-catalyzed esterification. Also disclosed herein are methods of use of the products produced by any of the methods herein.

专利号:US-4910310-A
优先权日:1988-10-03
标 题:Synthesis of N-substituted 1,5-dideoxy-1,5-imino-L-fucitol derivatives
发明人:CAMPBELL ARTHUR L; BEHLING JAMES R; BABIAK KEVIN A; NG JOHN S; MUELLER RICHARD A; FLEET GEORGE W J
权利人:SEARLE & CO
摘要:Novel intermediates and method for the chemical synthesis of N-substituted 1,5-dideoxy-1,5-imino-L-fucitol derivatives are provided. A preferred intermediate is 1,5-dideoxy-1,5-imino-3, 4-O-isopropylidene-L-fucitol which is used to prepare the HIV inhibitor 1,5-dideoxy-1,5-imino-[N-ω-methyl caproate]-L-fucitol. These compounds are prepared in a short synthesis from the known compound 2,3-O-isopropylidene-D-lyxono-1,4-lactone or in a multi-step synthesis from D-galactose.

专利号:US-7314960-B1
优先权日:2006-09-28
标 题:Catalytic synthesis of oxygenate from alcohol
发明人:LIN SHENG-DIANN; HSIAO TING-CHOU
权利人:UNIV YUAN ZE
摘要:The present invention discloses a method for catalytic synthesis of oxygenate from alcohol. At first, a feeding material comprising at least one alcohol is provided. Next, a copper-containing catalyst is provided and the catalyst further comprises at least one metal element selected from the group consisting of the following: zinc, magnesium, and aluminum elements. Following that, a catalytic reaction of the feeding material over the copper-containing catalyst is carried out to synthesize at least one oxygenate.

专利号:US-10882813-B2
优先权日:2014-12-17
标 题:Method for the synthesis of ferric oraganic compounds
发明人:PULLAGURLA MANIK REDDY; NANDA KUMAR MECHERIL VALSAN; RANGISETTY JAGADEESH BABU; BHUDETI RAJESH; NAGARAPU RADHA
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The present invention relates to an improved method for the synthesis of Ferric Citrate and also to provide an amorphous form of Ferric Citrate having an active surface area less than 14 sq.m/g.

专利号:US-8664357-B2
优先权日:2008-08-08
标题 :Solvent resistant diafiltration of peptides, PNA or oligonucleotides
发明人:LIVINGSTON ANDREW GUY; PEEVA LUDMILA GEORGIEVA; SO SHEYUNG WANG JERRY; CAMPOS VASCONCELES RENATO; LEATHERBARROW ROBIN JOHN; TATE EDWARD WILLIAM; GAFFNEY PIERS ROBERT JAMES
权利人:LIVINGSTON ANDREW GUY; PEEVA LUDMILA GEORGIEVA; SO SHEYUNG WANG JERRY; CAMPOS VASCONCELES RENATO; LEATHERBARROW ROBIN JOHN; TATE EDWARD WILLIAM; GAFFNEY PIERS ROBERT JAMES; IMP INNOVATIONS LTD
摘要:According to the present invention, there is provided a process for the preparation of a first compound selected from peptides, oligonucleotides and peptide nucleic acids. The process comprises synthesizing the first compound and then separating the first compound formed in step (i) from a second compound, which is a reaction by-product of the synthesis of the first compound and/or an excess of a reagent used for the synthesis of a first compound by a process of diafiltration. The membrane used for the diafiltration process is stable in organic solvents and provides a rejection for the first compound which is greater than the rejection for the second compound.

专利号:US-3772366-A
优先权日:1964-09-29
标 题 :Process for the preparation of 9beta,10beta steroids
发明人:USKOKOVIC M; WILLIAMS T
权利人:HOFFMANN LA ROCHE
摘要:THE PRESENT INVENTION IS DIRECTED TO A PROCESS FOR THE COMPLETE CHEMICAL SYNTHESIS OF STEROIDS HAVING THE 9B, 10A-CONFIGURATION FROM THE NATURAL STERIOIDS POSSESSING THE 9A, 10B-CONFIGURATION INCLUDING INTERMEDIATES IN THIS SYNTHESIS. THE STEROIDS WITH THE 9B,10A-CONFIGURATION ARE USEFUL AS ANABOLIC AGENTS, ANTI-ANDROGENIC AGENTS, PROGESTATIONAL AGENTS AND AS SALT-RETAINING AGENTS.
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✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: G A Eiceman, Et Al. Ion Mobility Spectrometry Of Hydrazine, Monomethylhydrazine, And Ammonia In Air With 5-Nonanone Reagent Gas. Anal Chem. 1993:65:1696-702.
[参考文献]: J L O'Donoghue, Et Al. Commercial-Grade Methyl Heptyl Ketone (5-Methyl-2-Octanone) Neurotoxicity: Contribution Of 5-Nonanone. Toxicol Appl Pharmacol. 1982 Feb;62(2):307-16.
[参考文献]: M A Shifman, Et Al. The Neurotoxicity Of 5-Nonanone: Preliminary Report. Toxicol Lett. 1981 Jun-Jul;8(4-5):283-8.
[参考文献]: Peter S Toth, Et Al. Novel Organic Solvents For Electrochemistry At The Liquid/liquid Interface. Analyst. 2015 Mar 21;140(6):1947-54.

合成参考文献


摘要:Takeda, T.; Tsubouchi, A., Science of Synthesis, (2009) 46, 87.
摘要:Zaidlewicz, M.; Krzemiński, M. P.; Dzieleńdziak, A., Science of Synthesis, (2009) 48, 388.
摘要:Molnár, Á.; Margaretha, P., Science of Synthesis, (2009) 48, 463.
摘要:Chciuk, T. V.; Flowers, R. A.; Flowers, R. A., Science of Synthesis Knowledge Updates, (2016) 2, 260.
摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 399.
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