CAS: 485-19-8; (S)-1-(3-Hydroxy-4-Methoxybenzyl)-6-Methoxy-2-Methyl-1,2,3,4-Tetrahydroisoquinolin-7-Ol

上下游产品

CAS号621-59-0 异香兰素； 3-羟基-4-甲氧... | CAS号2426-87-1 4-苄氧基-3-甲氧基苯甲醛 | CAS号22231-61-4 4-苄氧基-3-甲氧基苯乙胺 | CAS号1860-60-2 (4-甲氧基-3-苯基甲氧基苯基)甲醇 | CAS号63909-38-6 反-4-苄氧基-3-甲氧基-β... | CAS号55667-12-4 2-苄氧基-4-溴甲基-1-甲氧基苯 | CAS号121-33-5 香草醛 | CAS号3621-36-1 非洲防己碱 | CAS号3019-51-0 异波尔定碱 | CAS号4090-18-0 清风藤碱 | CAS号517-56-6 紫堇块茎碱 | CAS号25650-75-3 (9α,13α)-5,6,8,... | CAS号483-45-4 [13aS,(-)]-5,8,... | CAS号605-34-5 discretamine | CAS号56435-41-7 6',7'-dimethoxy... | CAS号32728-75-9 卡维丁 | CAS号524-46-9 [6S,(+)]-6-[(1S...

📜多巴胺置于2-吗啉乙磺酸,抗坏血酸,异丙基-Beta-D-硫代半乳糖吡喃糖苷体系中,化学反应生成 牛心果碱
参考文献:实验室规模的生产(S)-网红,一种基于细菌的方法,是苄基异喹啉生物碱的重要中间体.
标题:实验室规模的生产(S)-网红,一种基于细菌的方法,是苄基异喹啉生物碱的重要中间体.
摘要:苄基异喹啉生物碱(bias)是一组植物次生代谢产物,由于其多种药物活性,已被确定为药物发现的目标.众所周知的bia在植物中相对丰富,因此已被广泛研究.然而,尽管未知的bia也被认为具有有价值的活性,但由于原料的存在量很低,因此很难获得.我们以前曾报道过使用大肠杆菌从多巴胺发酵生产重要的中间体(S)-网状茶碱.但是,收率通常受到限制.在这里,我们通过将大肠杆菌中的体内四氢罂粟碱与体外酶促合成(S)-网状茶碱相结合,提高了生产效率.最后,从1L反应混合物中获得593Mg纯的(S)-网状茶碱.由于这种基于细菌的方法很简单,因此可以广泛用于(S)-网状茶碱和相关bia的生产,从而促进了用于药物发现的bia的研究.
DOI:10.1080/09168451.2016.1243985

专利信息

专利号:US-12091696-B2
优先权日:2022-08-10
标 题 :O-methyltransferase protein with highly specific catalytic function for multiple bias parent nuclei and encoding gene and use thereof
发明人：CHEN SHA; YU YUETONG
权利人:INST CHINESE MATERIA MEDICA CHINA ACADEMY OF CMS
摘要:The present disclosure provides an O-methyltransferase protein with a highly specific catalytic function for multiple benzylisoquinoline alkaloids (BIAs) parent nuclei and an encoding gene and use thereof. Compared with wild-type O-methyltransferase, the O-methyltransferase protein (SEQ ID NO: 2) shows an enhanced enzymatic activity and a wider substrate scope. The O-methyltransferase protein can catalyze O-methylation of backbones from three BIAs, including monobenzylisoquinolines (norcoclaurine, coclaurine, and N-methylcoclaurine), aporphines (asimilobine and N-methylasimilobine), and protoberberines (scoulerine and tetrahydrocolumbamine). Meanwhile, this O-methyltransferase protein is highly regioselective for each backbone. The O-methyltransferase protein catalyzes methylation of the monobenzylisoquinolines at 6-OH and 7-OH, is only active on 6-OH of the backbone of the aporphines, and mainly catalyzes methylation of the protoberberines at 2-OH. Moreover, the O-methyltransferase protein has a stronger catalytic activity and can be used as a biocatalyst for the semi-synthesis of related compounds.

专利号:US-3894027-A
优先权日:1973-07-31
标 题:Resolution of racemic reticuline and racemization of its enantiomers
发明人：SOHAR PAUL; SCHOENEWALDT ERWIN F
权利人:MERCK & CO INC
摘要:Racemic reticuline is resolved by forming a crystalline diastereomeric acid salt with a mandelic acid enantiomer. The reticuline enantiomers are racemized by treatment with a reduced noble metal or noble metal oxide catalyst. (-)-Reticuline is a valuable intermediate useful in the synthesis of thebaine, and (+)-reticuline is useful as a precursor of pallidine, sinoacutine, coreximine, and the berberine alkaloids.

专利号:WO-2025031833-A1
优先权日:2023-08-04
标 题:Recombinant strain and use thereof in production of scoulerine
发明人：CHEN YUN; JIAO XIANG
权利人:CHRYSEA LTD; CHEN YUN
摘要:Disclosed are recombinant yeast strains and a use thereof in the production of a benzylisoquinoline alkaloid. The recombinant yeast strains comprise berberine bridge enzyme. De novo synthesis of scoulerine and a benzylisoquinoline alkaloid is achieved through multiple strategies, and the yield thereof is significantly increased. The recombinant yeast strains provided by the present invention can produce scoulerine and other benzylisoquinoline alkaloids at high efficiency, and has important value in applications.

专利号:US-12416029-B2
优先权日:2016-06-27
标 题 :Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof
发明人：FACCHINI PETER JAMES; CHEN XUE; COLBECK JEFFREY C; TUCKER JOSEPH E
权利人:ANTHEIA INC
摘要:Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids (“BIAsâ€?) such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone, hydroxycodeinone, neopinone, and/or buprenorphine. Compositions and organisms useful for the synthesis of BIAs, including thebaine synthesis polypeptides, purine permeases, and polynucleotides encoding the same, are provided.

专利号:US-10793885-B2
优先权日:2013-08-16
标 题 :Compositions and methods for making noscapine and synthesis intermediates thereof
发明人：FACCHINI PETER JAMES; CHEN XUE; DANG THI THU THUY
权利人:WILLOW BIOSCIENCES INC
摘要:Methods for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates comprising contacting a noscapine pathway precursor selected from a first canadine derivative, a first papaveroxine derivative and narcotine hemiacetal with at least one of the enzymes selected from the group CYP82Y1, CYP82X1, AT1, CYP82X2, OMT, CXE1 and NOS.

专利号:EP-3137618-A1
优先权日:2014-04-29
标 题 :Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds