CAS: 35480-52-5; 2,5-Bis(2,2,2-Trifluoroethoxy)Benzoic Acid

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CAS号75-89-8 三氟乙醇 | CAS号21739-92-4 5-溴-2-氯苯甲酸 | CAS号1023951-32-7 2,5-bis(2,2,2-t... | CAS号35480-31-0 2,5-双三氟乙氧基苯甲酸甲酯 | CAS号57415-36-8 N-(2-吡啶基甲基)-2,5... | CAS号50778-59-1 2,5-bis(2,2,2-t...

2,5-双(2,2,2-三氟乙氧基)苯甲酸甲酯置于水,Potassium Hydroxide体系中,用930 G的收率获得2,5-双(2,2,2-三氟乙氧基)苯甲酸
参考文献:一种2,5-双(2,2,2-三氟乙氧基)苯甲酸的制备方法
标题:一种2,5-双(2,2,2-三氟乙氧基)苯甲酸的制备方法
摘要:一种2,5‑双(2,2,2‑三氟乙氧基)苯甲酸的制备方法,以2,5‑二氟溴苯为原料经过腈化反应,三氟乙氧基化,酯化反应,水解反应合成2,5‑双(2,2,2‑三氟乙氧基)苯甲酸,本发明提供了一条新的合成路线,以2,5‑二氟溴苯为初始原料,经过腈化反应,三氟乙氧基化,酯化反应,水解反应合成2,5‑双(2,2,2‑三氟乙氧基)苯甲酸,制备过程简单,条件易控制,易于实现工业化生产,且得到的2,5‑双(2,2,2‑三氟乙氧基)苯甲酸纯度98%,总收率达到40.9%.

专利信息

专利号:US-7196197-B2
优先权日:2003-09-17
标题:Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof
发明人：WANG ZHI-XIAN; LI YUANQIANG; GUNTOORI BHASKAR REDDY
权利人:APOTEX PHARMACHEM INC
摘要:Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof that involves the use of the 2-halobenzoic acid and its derivatives as a starting material. The use of this process also allows for the synthesis of a novel intermediate useful in the production of Flecainide. This new process is an inexpensive and efficient process for the manufacture of these compounds.

专利号:US-6599922-B2
优先权日:2001-08-10
标 题:Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide (FLECAINIDE)
发明人：VIGANO ENRICO; PIZZATTI ENRICA; MOLTENI RENATO; LANFRANCONI SIMONA
权利人:A M S A ANONIMA MATERIE SINT E
摘要:Process for the synthesis of FLECAINIDE comprising the reaction between 2,5-dihydroxybenzoic acid with trifluoroethanol perfluorobutanesulphonate to give the intermediate trifluoroethanol 2,5-bis-trifluoroethoxybenzoate, the reaction of said intermediate with 2-aminomethylpiperidine to give FLECAINIDE.

专利号:US-2004220409-A1
优先权日:2001-02-20
标题 :Flecainide synthesis
发明人：MCDANIEL WILLIAM C; RADHAKRISHNAN JAYARAMAIYER; JANICKI SLAWOMIR J
权利人:MCDANIEL WILLIAM C; RADHAKRISHNAN JAYARAMAIYER; JANICKI SLAWOMIR J
摘要:An improved, highly efficient method for the preparation of flecainide acetate (I) or other pharmaceutically acceptable salts of flecainide. The method involves a technique for preparing the staring material 1,4-bis (2,2,2-trifuoroethoxy) benzene (III) in high yields by reacting 4-fluoro-1-bromobenzene (VI) with TFE in the presence of a base and a copper-containing catalyst.