CAS: 3435-25-4; 4-Chloro-6-Methylpyrimidine
该化合物是一种卤化的火米丁衍生物,广泛用作有机合成和制药研究的多用途中间体,其4位置的活性氯组能够产生有效的核生殖替代反应,便利采用各种功能组.6位置的甲基替代成分能够增强稳定性,影响电子特性,使其对建造热循环化合物具有价值.该化合物对于发展农用化学品,药品和特殊化学品特别有用.其高纯度和持续的再活动确保了合成应用的可靠性能.由于对湿度和潜在刺激特性的敏感性,建议在受控制条件下进行适当处理.
- 相似结构搜索
- 产品信息参考
; - InChIKey: MVAXKFAQKTWRAH-UHFFFAOYSA-N
- InChI=1S/C5H5ClN2/c1-4-2-5(6)8-3-7-4/h2-3H,1H3
- 计算化学: 氢键受体数2.0氢键供体数*可旋转键数*
相似化合物
5424-21-5 4472-45-1 141602-25-7物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2
急性毒性 类别4(吸入)
急性毒性 类别4(经皮)
急性毒性 类别4(经口)
严重眼刺激 类别2A - 警示词Warning(警告)
- 危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
欧盟法规
ECHA物质C&L通报上下游产品
CAS号1193-21-1 4,6-二氯嘧啶 | CAS号676-58-4 甲基氯化镁 | CAS号3524-87-6 4-羟基-6-甲基嘧啶 | CAS号3438-55-9 5-溴-4-氯-6-甲基嘧啶 | CAS号98-80-6 苯硼酸 | CAS号822-36-6 4-甲基咪唑 | CAS号67-66-3 氯仿 | CAS号4718-50-7 4-乙氧基-6-甲基嘧啶 | CAS号3435-28-7 4-氨基-6-甲基嘧啶 | CAS号3438-46-8 4-甲基嘧啶 | CAS号28840-41-7 4-Pyrimidinecar... | CAS号17759-27-2 4-methyl-6-phen... | CAS号74647-33-9 (9CI)-4-乙基-6-甲基嘧啶 | CAS号99356-90-8 (6CI)-4-二甲基氨基-6-甲基嘧啶 | CAS号62671-89-0 Pyrimidine, 4-m... | CAS号55849-46-2 4-甲基-6-苯基嘧啶合成工艺路线路线简述
📜4-Chloro-6-Methylpyrimidine置于三氯氧磷体系中,用75%的收率获得产物4-氯-6-甲基嘧啶
参考文献:Synthesis And Biological Activity Of Hydrochlorides Of Benzyl Ethers Of Pyrimidin-4(3H)-Thiones And Related Compounds
标题:Synthesis And Biological Activity Of Hydrochlorides Of Benzyl Ethers Of Pyrimidin-4(3H)-Thiones And Related Compounds
摘要:Hydrochlorides Of Benzyl Ether Of 2-Amino-6-Methylpyrimidin-4(3H)-Thione And Its Analogs Were Synthesized And Biological Activity Of The Synthesized Compounds Was Studied.
DOI:10.1134/s1070363215010144
专利信息
专利号:US-9714226-B2
优先权日:2011-07-29
标题:Hydrazide containing nuclear transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT P; SHACHAM SHARON; MCCAULEY DILARA; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: n nor a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.
专利号:RU-2194701-C2
优先权日:1995-12-18
标 题 :Derivatives of quinazoline, methods of their synthesis, pharmaceutical composition comprising thereof and method of achievement of anti-angiogenic effect and/or effect of decrease of vascular penetration with their using
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1055/s-0030-1260224
摘要:Czarnocki Z, Błachut D, Szawkało J. Suzuki-Miyaura and Negishi Approaches to a Series of Forensically Relevant Pyridines and Pyrimidines. Synthesis. 2011 Sep 13;2011(21):3496–506. doi: 10.1055/s-0030-1260224.
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