专利号:US-7884182-B2 优先权日:2001-11-14 标 题 :Chemical peptide ligation with three or more components 发明人:BOTTI PAOLO; GAERTNER HUBERT; MANGANIELLO SONIA; VILLAIN MATTEO 权利人:AMYLIN PHARMACEUTICALS INC 摘要:The invention provides a method of assembling oligopeptide intermediates in a native chemical ligation reaction that eliminates self-ligation of bi-functional intermediates. An important aspect of the invention is a bi-functional intermediate with an N-terminal heterocyclic protecting group which effectively prevents self-ligation in the chemical assembly process. The present invention is useful in methods for convergent synthesis of polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where three or more peptide fragments are used to assemble a polypeptide or protein product.
专利号:ES-2249986-B1 优先权日:2004-07-02 标 题 :SYNTHESIS OF FLUORESCENT DERIVATIVES OF TACROLIMUS (FK506) AND ITS USE IN THE CHARACTERIZATION OF THE INTERACTION OF FK506 WITH PROTEINS UNION TO FK506.
专利号:ES-2249986-A1 优先权日:2004-07-02 标 题 :Synthesis of fluorescent derivatives of tacrolimus (FK506) consists of a cellular interaction promotion and proteins based union technique
专利号:CN-103626693-A 优先权日:2012-08-28 标 题 :A class of pleuromutilin derivatives, its pharmaceutical composition and its synthesis method and application
专利号:RU-2024527-C1 优先权日:1986-03-25 标 题 :Method of macrolide compounds synthesis
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合成参考文献
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