CAS: 12126-59-9; Premarin

专利信息

专利号:US-9290699-B2
优先权日:2012-06-18
标 题 :Process for synthesizing hydrocarbons from synthesis gas with control of the temperature of the external loop
发明人：HERAUD JEAN PHILIPPE; VIGUIE JEAN CHRISTOPHE; BOUCHER SEBASTIEN; DELLA TORRE CHIARA; MIGNONE ELSA
权利人:IFP Energies Nouvelles; ENI SPA
摘要:The present invention concerns a process for the synthesis of hydrocarbons from a feed comprising synthesis gas, in which a solid catalyst comprising cobalt is used in a three-phase reaction section operated such that said catalyst is maintained in suspension in a liquid phase by movement of a gas phase from the bottom to the top of said reaction section, said process comprising an external loop for separating waxes, characterized in that:n 1) the theoretical ratio P H2O :P H2 in the external loop for separating waxes is determined using the following calculation:n nP H2O :P H2 theoretical= Cv /( R 1− Rft×Cv )n where Cv=(CO inlet −CO degas )/CO inlet R1=H 2 inlet /CO inlet Rft=(H 2 inlet −H 2 degas )/(CO inlet −CO degas ) n 2) if the theoretical ratio P H2O :P H2 determined in step 1) has a value of R threshold or higher, the temperature in the degassing means for the external loop for separating waxes is reduced, 3) steps 1) to 2) are repeated until the theoretical ratio P H2O :P H2 has a value strictly less than R threshold , where R threshold is in the range 0.1 to 1.1.

专利号:US-10457640-B2
优先权日:2016-10-19
标 题:Synthesis of inhibitors of EZH2
发明人：VASWANI RISHI G; HEWITT MICHAEL CHARLES
权利人:CONSTELLATION PHARMACEUTICALS INC
摘要:Provided herein are synthetic methods for the preparation of EZH2 inhibitors.

专利号:US-9365532-B1
优先权日:2011-02-14
标题:Synthesis, composition and use of novel therapeutic and cosmetic Schiff base products formed by reaction of a carbonyl containing moeity with a transimination nucleophilic catalyst and the use of transimination nucleophilic catalysts to increase the rate at which carbonyl containing therapeutic and cosmetic actives form Schiff base products with biological amines
发明人：ISAACMAN STEVEN
权利人:ISAACMAN STEVEN; NANOMETICS LLC
摘要:The present invention relates to the synthesis, composition and use of novel moieties formed by reacting a transimination nucleophilic catalyst, molecular or polymeric, with carbonyl-containing therapeutic or cosmetic moieties. The resultant Schiff base product is highly reactive towards transimination with a biological amine. The catalyst and carbonyl-containing moiety can be molecular or polymeric, and the resultant chemical and physical properties of the Schiff base products can be engineered by appropriate selection of said catalyst. The present invention also relates to the synthesis, composition and use of novel moieties that are used as actives in sunless tanning preparations. The present invention also relates to the use of transimination nucleophilic catalysts to increase the rate at which a carbonyl-containing moiety reacts with a biological amine. The present invention also relates to the use of transimination nucleophilic catalysts to increase the rate and efficacy of commercial sunless tanning preparations. Improvements on stability and efficacy of said preparations are disclosed. While the invention has been described in terms of its preferred embodiments, those skilled in the art will recognize that the invention can be practiced with modification within the spirit and scope of the appended claims. Accordingly, the present invention should not be limited to the embodiments as described above, but should further include all modifications and equivalents thereof within the spirit and scope of the description provided herein.

专利号:US-2019031650-A1
优先权日:2016-01-29
标 题 :Dna alkylation and cross-linking agents as compounds and payloads for targeted therapies
发明人：HERZON SETH; HEALY ALAN; CRAWFORD JASON; VIZCAINO MARIA; NIKOLAYEVSKIY HERMAN
权利人:UNIV YALE
摘要:The present invention is directed to compounds related to precolibactin pharmaceutical compositions based upon these compounds and methods of synthesis which are employed to provide intermediates and final compounds, which are principally alkylating agents and anticancer compounds. The chemical synthetic approach disclosed facilitates the synthesis of numerous precolibactin analogs which can be used in the treatment of cancer.

专利号:US-2003158432-A1
优先权日:2002-01-08
标 题:Synthesis of a mixture of sulfated estrogens using a sulfur trioxide complex

专利号:US-2019233375-A1
优先权日:2016-10-19
标题:Synthesis of inhibitors of ezh2