专利号:US-2005020616-A1 优先权日:2003-07-21 标 题 :Aryl fused azapolycyclic compounds 发明人:COE JOTHAM W; O'DONNELL CHRISTOPHER J 权利人:PFIZER 摘要:This invention is directed to compounds of the formula (I): n n nand their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 and Z are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of neurological and psychological disorders.
专利号:US-7205300-B2 优先权日:1997-12-31 标 题:Aryl fused azapolycyclic compounds 发明人:COE JOTHAM WADSWORTH; BROOKS PAIGE ROANNE PALMER 权利人:PFIZER 摘要:This invention is directed to compounds of the formula (I): n nand their pharmaceutically acceptable salts, wherein R 1 , R 2 , and R 3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of neurological and psychological disorders.
专利号:US-11767388-B1 优先权日:2019-09-18 标 题 :Silicon-functionalized rubber 发明人:ENSIGN SETH CODY; VIELHABER MARGARET FLOOK; JOHNGRASS JENA LYNN; MA LIQING 权利人:GOODYEAR TIRE & RUBBER 摘要:The compatibility between silica fillers and synthetic rubbers which are synthesized utilizing lanthanide-based catalyst systems, such as neodymium catalyst systems can be improved by terminating the polymerization with a vinyl silane terminating agent. In doing so the vinyl silane is allowed to react with the polymer chain ends of the neodymium rubber to functionalize the chain ends of the polymer chains with silicon containing groups. This results in the rubber having better characteristics for utilization in tire rubber formulations, such a tire tread formulations, that exhibit improved wear characteristics and lower rolling resistance. The process for the synthesis of such functionalized polydiene rubber comprises (1) polymerizing a diene monomer in the presence of a lanthanide-based catalyst system, and (2) terminating the polymerization with a vinyl silane terminator. The functionalized polydiene rubber composition made by this method is comprised of a polydiene rubber which is functionalized at its chain ends with a silicon containing group.
专利号:US-7122534-B2 优先权日:1998-04-29 标 题:Aryl fused azapolycyclic compounds 发明人:COE JOTHAM WADSWORTH 权利人:PFIZER 摘要:The present invention relates to compounds of formula (I) n n nand their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 and Z are as defined herein, intermediates in the synthesis of such compounds, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of neurological and psychological disorders.
专利号:WO-0002864-A1 优先权日:1998-07-10 标题:Precusors for pna-monomers 发明人:MARTENS JUERGEN; MAISON WOLFGANG; SCHLEMMINGER IMRE; WESTERHOFF OLE; GROEGER HARALD 权利人:MARTENS JUERGEN; MAISON WOLFGANG; SCHLEMMINGER IMRE; WESTERHOFF OLE; GROEGER HARALD 摘要:The invention is directed to compounds of formula (I) wherein A, B, D, E, X and Y are defined in the description. These compounds are useful precursors for the synthesis of monomers for Peptide Nucleic Acids (PNA).
专利号:DE-69522642-T2 优先权日:1994-05-18 标 题:HYMENIALDISINE AND ITS DERIVATIVES, METHOD FOR THE PRODUCTION OF INTERMEDIATE PRODUCTS FOR THEIR SYNTHESIS AND Said INTERMEDIATE PRODUCTS
参考标题:Novel Applications Of Convertible Isonitriles For The Synthesis Of Mono And Bicyclic γ-Lactams Via A Udc Strategy 作者:Christopher Hulme,Liang Ma,Marie-Pierre Cherrier,Joseph J Romano,George Morton,Celine Duquenne,Joseph Salvino,Richard Labaudiniere |发布日期:2000.3 摘要:Application Of The So-Called Convertible Isonitriles For The Solution/solid Phase Generation Of γ-Lactam Analogues. Use Of Tethered N-Boc Aldehydes In The Ugi Multi-Component Reaction (Mcr), Followed By Boc Removal And Base Treatment (A '3-Step, 1-Pot Procedure') Affords γ-Lactams In Good Yield. The Udc (Ugi/de-Boc/cyclize) Strategy, Coupled With A Convertible Isonitrile, Is Now Feasible From All Three
合成参考文献
摘要:Wessjohann, L. A.; Kaluđerović, G. N.; Neves Filho, R. A. W.; Morejon, M. C.; Lemanski, G.; Ziegler, T., Science of Synthesis: Multicomponent Reactions, (2013) 1, 485. 摘要:Wessjohann, L. A.; Kaluđerović, G. N.; Neves Filho, R. A. W.; Morejon, M. C.; Lemanski, G.; Ziegler, T., Science of Synthesis: Multicomponent Reactions, (2013) 1, 435. 摘要:Wessjohann, L. A.; Kaluđerović, G. N.; Neves Filho, R. A. W.; Morejon, M. C.; Lemanski, G.; Ziegler, T., Science of Synthesis: Multicomponent Reactions, (2013) 1, 442. 摘要:Wessjohann, L. A.; Kaluđerović, G. N.; Neves Filho, R. A. W.; Morejon, M. C.; Lemanski, G.; Ziegler, T., Science of Synthesis: Multicomponent Reactions, (2013) 1, 491.