1,2-二苯乙烷置于copper(II) Perchlorate Sodium Hydroxide,高氯酸,Fe(Clo4),Peroxodisulfate Ion,Pyridinium Chlorochromate体系中,用 四氢呋喃,水,乙腈 用作溶剂,化学反应 0.42H,反应生成4-甲氧基-2-苯基苯乙酮 参考文献:Carbon-Hydrogen Vs. Carbon-Carbon Bond Cleavage Of 1,2-Diarylethane Radical Cations In Acetonitrile-Water 标题:Carbon-Hydrogen Vs. Carbon-Carbon Bond Cleavage Of 1,2-Diarylethane Radical Cations In Acetonitrile-Water 摘要: Doi:10.1021/jo00183A023
专利信息
专利号:US-5789576-A 优先权日:1994-12-09 标题 :Methylphosphonate dimer synthesis 发明人:DAILY WILLIAM J; SCHWARTZ DAVID AARON 权利人:GENTA INC 摘要:Processes for the stereospecific synthesis of 2',2''-bis(deoxy)di-nucleosides and for the stereoselective synthesis of 2',2''-bis(substituted) dinucleosides are provided. Also provided are activated 2'-substituted-nucleoside alkylphosphonate active esters useful in the synthesis of these dinucleosides.
专利号:WO-0019994-A9 优先权日:1998-10-02 标题 :Estrogen receptor ligands 发明人:KATZENELLENBOGEN JOHN A; KATZENELLENBOGEN BENITA S; FINK BRIAN E; STAUFFER SHAUN R; MORTENSEN DEBORAH S; SATTIGERI VISWAJANANI JITENDRA; HUANG YING 权利人:UNIV ILLINOIS 摘要:This invention provides non-steroidal estrogen receptor ligands having a modular structure that is amenable to solid phase synthesis and the application of combinatorial synthetic methods to prepare these estrogen receptor ligands. ER ligands of this invention consist of a core scaffold that is a carbocyclic or heterocyclic-5-member ring that has two double bonds or a 6-member aromatic ring. A plurality of selected substituents are bonded to the ring substantially independently of other substituents. The modular structure of these compounds allows for synthesis of a very large numer of substituent structural variations, substituent combinations and substituent positioning on the core. The structural variants of the ER ligands of this invention exhibit a spectrum of selective affinities for ERα and ERβ and a spectrum of agonist/antagonist properties.
专利号:US-7138426-B2 优先权日:2002-04-24 标 题:Estrogen receptor modulators 发明人:DININNO FRANK P; BLIZZARD TIMOTHY ALLEN; MORGAN II JERRY DWAIN 权利人:MERCK & CO INC 摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
专利号:CN-118666704-A 优先权日:2023-03-15 标题 :Synthesis method of formoterol