CAS: 1023-17-2; 1-(4-Methoxyphenyl)-2-Phenylethanone

该化合物是一种多用途芳香酮,分子式为C15H14O2.该化合物具有一种甲基代氧苯基环和一种苯乙基组,具有独特的电子和静态特性.该化合物是有机合成中的宝贵中间体,特别是在制备药品,香料和精密化学品方面.甲基氧基化合物组增强了其在有机溶剂中的溶解性,并影响其耐受和减缩反应的再活性.其晶体结构和高纯度使其适合精确的合成应用.该化合物在温和条件下的稳定性以及与各种催化剂的兼容性进一步突出了其在复杂的化学转化中的效用.

结构式图片

相似化合物

24845-40-7 120-44-5 1226-42-2

欧盟法规

C&L通报

上下游产品

ethanol 2-hydroxy-2-(4-methoxy-phenyl)-3-phenyl-propionic acid 4-methoxybenzoin phenylacetic acid 1-(4-methoxy-phenyl)-2,4,5-triphenyl-pentane-1,5-dione β-4-methoxyphenyl-β-methylstyrene 1-(4-methoxyphenyl)-2-phenyl-2-propen-1-one 1,5-bis-(4-methoxy-phenyl)-2,4-diphenyl-pentane-1,5-dione

合成工艺路线路线简述

    1,2-二苯乙烷置于copper(II) Perchlorate Sodium Hydroxide,高氯酸,Fe(Clo4),Peroxodisulfate Ion,Pyridinium Chlorochromate体系中,用 四氢呋喃,水,乙腈 用作溶剂,化学反应 0.42H,反应生成4-甲氧基-2-苯基苯乙酮
    参考文献:Carbon-Hydrogen Vs. Carbon-Carbon Bond Cleavage Of 1,2-Diarylethane Radical Cations In Acetonitrile-Water
    标题:Carbon-Hydrogen Vs. Carbon-Carbon Bond Cleavage Of 1,2-Diarylethane Radical Cations In Acetonitrile-Water
    摘要:
    Doi:10.1021/jo00183A023

    专利信息


    专利号:US-5789576-A
    优先权日:1994-12-09
    标题 :Methylphosphonate dimer synthesis
    发明人:DAILY WILLIAM J; SCHWARTZ DAVID AARON
    权利人:GENTA INC
    摘要:Processes for the stereospecific synthesis of 2',2''-bis(deoxy)di-nucleosides and for the stereoselective synthesis of 2',2''-bis(substituted) dinucleosides are provided. Also provided are activated 2'-substituted-nucleoside alkylphosphonate active esters useful in the synthesis of these dinucleosides.

    专利号:WO-0019994-A9
    优先权日:1998-10-02
    标题 :Estrogen receptor ligands
    发明人:KATZENELLENBOGEN JOHN A; KATZENELLENBOGEN BENITA S; FINK BRIAN E; STAUFFER SHAUN R; MORTENSEN DEBORAH S; SATTIGERI VISWAJANANI JITENDRA; HUANG YING
    权利人:UNIV ILLINOIS
    摘要:This invention provides non-steroidal estrogen receptor ligands having a modular structure that is amenable to solid phase synthesis and the application of combinatorial synthetic methods to prepare these estrogen receptor ligands. ER ligands of this invention consist of a core scaffold that is a carbocyclic or heterocyclic-5-member ring that has two double bonds or a 6-member aromatic ring. A plurality of selected substituents are bonded to the ring substantially independently of other substituents. The modular structure of these compounds allows for synthesis of a very large numer of substituent structural variations, substituent combinations and substituent positioning on the core. The structural variants of the ER ligands of this invention exhibit a spectrum of selective affinities for ERα and ERβ and a spectrum of agonist/antagonist properties.

    专利号:US-7138426-B2
    优先权日:2002-04-24
    标 题:Estrogen receptor modulators
    发明人:DININNO FRANK P; BLIZZARD TIMOTHY ALLEN; MORGAN II JERRY DWAIN
    权利人:MERCK & CO INC
    摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

    专利号:CN-118666704-A
    优先权日:2023-03-15
    标题 :Synthesis method of formoterol
    上海法默生物科技有限公司
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    合成参考文献


    摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 116.
    摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, .
    摘要:Collings, J. C., Science of Synthesis Knowledge Updates, (2013) 4, 368.
    摘要:Collings, J. C., Science of Synthesis Knowledge Updates, (2013) 4, 367.
    摘要:Schneider, C.; Sickert, M., Science of Synthesis Knowledge Updates, (2017) 3, 403.
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