CAS: 1008-88-4; 3-Phenylpyridine

该化合物是一种环环芳烃化合物,由三点方位的一个苯基组替代而成的环状环组成.这种结构具有独特的电子和消毒特性,使其成为有机合成和制药研究的宝贵中间体.其相融合的系统增强了稳定性和回活动性,便利了在离心设计,协调化学和材料科学方面的应用.该复合物显示出在普通有机溶剂中具有有利的溶解性,简化了处理和净化.其明确界定的芳香特性也使其在荧光色染料和光电子材料的开发中有用. 3-苯丙烯被广泛用于交叉反应和作为生物活性分子的建筑块.

结构式图片

相似化合物

4423-09-0 129013-83-8 127406-55-7

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合成工艺路线路线简述

    灭草隆置于盐酸,Sodium Hydroxide,亚膦酸,Sodium Nitrite体系中,用 水 用作溶剂,化学反应 47.92H,反应生成3-苯基吡啶
    参考文献:Tanaka,Fred S.; Wien,Ronald G.; Hoffer,Barry L.,Synthetic Communications,1983,Vol. 13,# 11,P. 951-958
    标题:Tanaka,Fred S.; Wien,Ronald G.; Hoffer,Barry L.,Synthetic Communications,1983,Vol. 13,# 11,P. 951-958

    海关参考信息

    专利信息


    专利号:US-6512081-B1
    优先权日:1997-07-21
    标题:Synthesis of dithioester chain transfer agents and use of bis(thioacyl) disulfides or dithioesters as chain transfer agents
    发明人:RIZZARDO ENZIO; THANG SAN HOA; MOAD GRAEME
    权利人:E I DUPONT NEMOURS AND COMPANY; COMMW SCIENT IND RES ORG
    摘要:This invention relates to the synthesis of dithiocarboxylic acid esters by reaction of bis(thioacyl) disulphides, thioacetals or vinylidane bis(thioether) with free-radicals (optionally in the presence of monomers). The invention also relates to processes for the synthesis of polymers utilising these dithioesters as polymerisation regulators (chain transfer agents) or to the use of bis(thioacyl) disulphides to generate dithioester chain transfer agents in situ.

    专利号:US-6492524-B1
    优先权日:2001-03-27
    标 题 :Process for the synthesis of an aryl pyridine base using a zeolite catalyst
    发明人:KULKARNI SHIVANAND JANARDAN; RAGHAVAN KONDAPURAM VIJAYA; NAGABANDI SRINIVAS; VIPPAGUNTA RADHA RANI
    权利人:COUNCIL SCIENT IND RES
    摘要:The present invention provides an improved process for the synthesis of aryl pyridine bases by reacting an aromatic aldehyde or ketone and allylic alcohol or aldehyde in presence of ammonia in gas phase, in high yield and selectivity with catalyst obtained by optionally modifying a zeolite having an atomic ratio of Si to Al, 2.5 to 12.5 and /or with at least one metal ion and/or metal compound selected from the group consisting of lead and lanthanum. This process provides an eco-friendly, more economical and highly selective heterogeneous method.

    专利号:US-6225329-B1
    优先权日:1998-03-12
    标 题 :Modulators of protein tyrosine phosphatases (PTPases)
    发明人:RICHTER LUTZ STEFAN; ANDERSEN HENRIK SUNE; VAGNER JOSEF; JEPPESEN CLAUS BEKKER; MOELLER NIELS PETER HUNDAHL; BRANNER SVEN; SU JING; BAKIR FARID; JUDGE LUKE MILBURN
    权利人:NOVO NORDISK AS
    摘要:The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like, n wherein A, R 1 , R 2 , R 3 , R 4 , R 16 and R 17 are as defined in the specification. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

    专利号:US-10899773-B2
    优先权日:2014-12-19
    标 题 :Total synthesis of trioxacarcin DC-45-A2 and preparation of trioxacarcin analogs
    发明人:NICOLAOU KYRIACOS C; CAI QUAN
    权利人:UNIV RICE WILLIAM M
    摘要:In one aspect, the present invention provides novel derivatives of trioxacarin analogs of the formula (I) wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.

    专利号:US-2005119332-A1
    优先权日:1998-03-12
    标 题 :Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases)
    发明人:JEPPESEN LONE; ANDERSEN HENRIK S; OLSEN OLE H; JUDGE LUKE M; HOLSWORTH DANIEL D; BAKIR FARID; AXE FRANK U; GE YU
    摘要:The present invention provides novel compounds of formula 1a, n nnovel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

    专利号:WO-9946244-A1
    优先权日:1998-03-12
    标题 :Modulators of protein tyrosine phosphatases (ptpases)
    发明人:JEPPESEN LONE; ANDERSEN HENRIK SUNE; OLSEN OLE HVILSTED; JUDGE LUKE MILBURN; HOLSWORTH DANIEL DALE; BAKIR FARID; AXE FRANK URBAN; GE YU
    权利人:NOVO NORDISK AS; ONTOGEN CORP
    摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.
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    主要参考文献

    [参考文献]: J P Collman, Et Al. Oxygenation Of Hydrocarbons By Cytochrome P-450 Model Compounds: Modification Of Reactivity By Axial Ligands. Proc Natl Acad Sci U S A. 1983 Nov;80(22):7039-41.
    [参考文献]: Leszek Pazderski, Et Al. 1H, 13C And 15N Nuclear Magnetic Resonance Coordination Shifts In Au(Iii), Pd(Ii) And Pt(Ii) Chloride Complexes With Phenylpyridines. Magn Reson Chem. 2009 Aug;47(8):658-65.
    [参考文献]: Marc P Bonaca, Et Al. Sch 530348: A Novel Oral Thrombin Receptor Antagonist. Future Cardiol. 2009 Sep;5(5):435-42.
    [参考文献]: P Sett, Et Al. Raman Excitation Profiles And Excited State Molecular Configurations Of Three Isomeric Phenyl Pyridines. Spectrochim Acta A Mol Biomol Spectrosc. 2000 Apr;56(5):855-75.
    [参考文献]: Sanjeev Kumar, Et Al. Structure Based Development Of Phenylimidazole-Derived Inhibitors Of Indoleamine 2,3-Dioxygenase. J Med Chem. 2008 Aug 28;51(16):4968-77.

    合成参考文献


    摘要:Delvos, L. B.; Oestreich, M., Science of Synthesis Knowledge Updates, (2017) 1, 151.
    摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 169.
    摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 138.
    摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 177.
    摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 193.
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