CAS: 1000025-07-9; Vadadustat

上下游产品

3-chlorophenylboronic acid 2-Cyano-3,5-dichloropyridine 5-(3-chlorophenyl)-3-chloro-2-cyanopyridine 5-(3-chlorophenyl)-3-methoxy-2-cyanopyridine

5-(3-Chlorophenyl)-2-(N-Glycine Methylester Carboxylic Amide)-3-(2,2-Dimethyl-1-Oxopropoxy) Pyridine置于水,Potassium Hydroxide,盐酸体系中,用 2-甲基四氢呋喃,水 用作溶剂,以90%的收率获得伐度司他
参考文献: Manufacturing Process For 3,5-Dichloropicolinonitrile For Synthesis Of Vadadustat[fr] Processus De Fabrication De 3,5-Dichloropicolinonitrile Pour La Synthèse De Vadadustat
标题: Manufacturing Process For 3,5-Dichloropicolinonitrile For Synthesis Of Vadadustat[fr] Processus De Fabrication De 3,5-Dichloropicolinonitrile Pour La Synthèse De Vadadustat
摘要:本文揭示了制备vadadustat或其药学上可接受的盐的方法和过程,以及用于合成vadadustat的中间体(例如,化合物式(i),(i-F),(II)或(iv)或其药学上可接受的盐).

专利信息

专利号:US-2023286918-A1
优先权日:2020-07-02
标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat
发明人：JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER
权利人:AKEBIA THERAPEUTICS INC
摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.

专利号:WO-2024170500-A1
优先权日:2023-02-13
标题:Methods of treating iron deficiency-related diseases
发明人：KAUTZ LÉON
权利人:INST NAT SANTE RECH MED; ECOLE NAT VETERINAIRE DE TOULOUSE; INSTITUT NATIONAL DE RECH POUR L’AGRICULTURE L’ALIMENTATION ET L’ENVIRONNEMENT; UNIV TOULOUSE III – PAUL SABATIER
摘要:Anemia, defined as a decreased quantity of circulating functional red blood cells, is a major source of morbidity and mortality affecting a-third of the worldwide population. As a functional component of erythrocytes hemoglobin, iron is essential for oxygen storage and transport. The liver-derived peptide hepcidin is the master regulator of iron homeostasis. During anemia, the erythroid hormone erythroferrone regulates hepcidin synthesis to ensure the proper supply of iron to the bone marrow for red blood cells synthesis. However, mounting evidence suggested that another factor may exert a similar function. Inventors identified the hepatokine FGL1 as a previously undescribed suppressor of hepcidin that is highly induced in the liver in response to hypoxia during the recovery from anemia and in thalassemic mice. Inventors demonstrated that FGL1 is a potent suppressor of hepcidin in vitro and in vivo. Deletion of Fgl1 in mice results in a blunted repression of hepcidin after bleeding. Finally, FGL1 is a BMP antagonist that directly binds BMP6 to impair the canonical BMP-SMAD signaling cascade that governs hepcidin regulation. Accordingly, the present invention relates to a FGL1 polypeptide for use in the treatment of a patient affected with an iron deficiency-related disease.

专利号:US-12269802-B2
优先权日:2018-05-09
标题:Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl] amino] acetic acid
发明人：GORIN BORIS I; LANTHIER CHRISTOPHER M; LUONG ANNE BUU CHAU; COPP JAMES DENSMORE; GONZALEZ JAVIER; JAUTZE SASCHA; KRAUS ERICH; O'CONNOR ALAN
权利人:AKEBIA THERAPEUTICS INC
摘要:Disclosed herein are methods and processes of preparing vadadustat and pharmaceutically acceptable salts thereof, and intermediates of formula (I) and their salts useful for the synthesis of vadadustat.

专利号:US-2024208898-A1
优先权日:2021-03-25
标 题 :Enamine n-oxides: synthesis and application to hypoxia-responsive prodrugs and imaging agents
发明人：KIM JUSTIN; KANG DAHYE; CHEUNG SHELDON T
权利人:DANA FARBER CANCER INST INC
摘要:Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.

专利号:WO-2022006427-A1
优先权日:2020-07-02
标题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat

专利号:US-10316018-B2
优先权日:2015-08-27
标题 :Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators
发明人：LEE KATHERINE LIN; ALLAIS CHRISTOPHE PHILIPPE; DEHNHARDT CHRISTOPH MARTIN; GAVRIN LORI KRIM; HAN SEUNGIL; HEPWORTH DAVID; LEE ARTHUR; LOVERING FRANK ELDRIDGE; MATHIAS JOHN PAUL; OWEN DAFYDD RHYS; PAPAIOANNOU NIKOLAOS; SAIAH EDDINE; STROHBACH JOSEPH WALTER; TRZUPEK JOHN DAVID; WRIGHT STEPHEN WAYNE; ZAPF CHRISTOPH WOLFGANG
权利人:PFIZER
摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.