CAS: 938-33-0; 8-Methoxyquinoline

该化合物是一种有机化合物,其特征是配有甲氧基组(-OCH)与环第八位置相连的肾上腺结构;它是在乙醇和丙酮等有机溶剂中溶解但水溶性有限的黄色至褐色固态;该化合物具有一系列有趣的化学特性,包括能够作为捆绑体与协调化学,形成各种金属离子体的复合体;其结构允许在制药等领域的潜在应用,在那里,它可能展示生物活动,包括抗微生物和抗脉搏特性;此外,8-甲基氧基酮可用于有机合成和作为分析化学中的荧光探针;安全数据表明,应当谨慎处理,因为接触时可能会对健康造成危害.

结构式图片

相似化合物

6931-17-5 1555-94-8 21269-34-1

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号148-24-3 8-羟基喹啉 | CAS号74-88-4 碘甲烷 | CAS号1416801-74-5 3-iodo-8-methox... | CAS号67-56-1 甲醇 | CAS号611-33-6 8-氯喹啉 | CAS号616-38-6 碳酸二甲酯 | CAS号36748-99-9 7-溴-8-甲氧基喹啉 | CAS号17012-50-9 5,7-diiodo-8-me... | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号75-09-2 二氯甲烷 | CAS号53899-17-5 8-甲氧基-1,2,3,4-四氢喹啉 | CAS号10500-57-9 5,6,7,8-四氢喹啉 | CAS号75414-07-2 8-Methoxy-5,6,7... | CAS号6640-50-2 8-羟基-1,2,3,4-四氢喹啉 | CAS号148-24-3 8-羟基喹啉 | CAS号14631-46-0 5,6,7,8-四氢-8-羟基喹啉 | CAS号10522-47-1 5-溴-8-甲氧基喹啉 | CAS号17012-47-4 8-methoxy-5-nit... | CAS号70945-35-6 8-methoxyquinol... | CAS号676255-10-0 N-B°C-8-羟基四氢喹啉

合成工艺路线路线简述

  • 148-24-3 = 938-33-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 48 H,Reflux
    标题:A Novel Leishmania Major Amastigote Assay In 96-Well Format For Rapid Drug Screening And Its Use For Discovery And Evaluation Of A New Class Of Leishmanicidal Quinolinium Salts
    作者:Bringmann,Gerhard; Thomale,Katja; Bischof,Sebastian; Schneider,Christoph; Schultheis,Martina; Et Al
    参考文献:Antimicrobial Agents And Chemotherapy 日期:2013 卷标:57(7) 页码:3003-3011]

    148-24-3 = 938-33-0
    反应条件:1.1 Reagents: Potassium Tert-Butoxide Solvents: Tetrahydrofuran; 3 H,Reflux1.2 6 H,Rt
    标题:Synthesis,Spectroscopy And Computational Studies Of Some Biologically Important Hydroxyhaloquinolines And Their Novel Derivatives
    作者:Malecki,Grzegorz; Nycz,Jacek E.; Ryrych,Ewa; Ponikiewski,Lukasz; Nowak,Maria; Et Al
    参考文献:Journal Of Molecular Structure 日期:2010 卷标:969(1-3) 页码:130-138]

    762-42-5 + 148-24-3 = 938-33-0
    反应条件:1.1 Reagents: 1-Methylimidazole; 1 Min,Rt1.2 20 S,Rt; 7 Min,100 °C
    标题:N-Methylimidazole-Mediated Synthesis Of Aryl Alkyl Ethers Under Microwave Irradiation And Solvent Free Conditions
    作者:Djahaniani,Hoorieh; Aghadadashi-Abhari,Laila; Mohtat,Bita
    参考文献:Journal Of The Serbian Chemical Society 日期:2015 卷标:80(4) 页码:459-464]

    148-24-3 = 938-33-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 30 Min,Rt1.2 Rt; Overnight,Rt
    标题:Synthesis And Biological Evaluation Of Quinoline Derivatives As Potential Anti-Prostate Cancer Agents And Pim-1 Kinase Inhibitors
    作者:Li,Kun; Li,Ying; Zhou,Di; Fan,Yinbo; Guo,Hongye; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2016 卷标:24(8) 页码:1889-1897]

    682351-22-0 = 938-33-0
    反应条件:1.1 Solvents: Ethanol; Reflux
    标题:Heteroannulation Of 3-Bis(Methylthio)Acrolein With Aromatic Amines - A Convenient Highly Regioselective Synthesis Of 2-(Methylthio)Quinolines And Their Benzo/hetero Fused Analogs - A Modified Skraup Quinoline Synthesis
    作者:Panda,Kausik; Siddiqui,Iffat; Mahata,Pranab K.; Ila,Hiriyakkanavar; Junjappa,Hiriyakkanavar
    参考文献:Synlett 日期:2004 卷标:(3) 页码:449-452]

    148-24-3 = 938-33-0
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Tetrahydrofuran; 15 Min,Rt1.2 Rt; Overnight,Rt
    标题:Experimental And Computational Exploration Of Para-Selective Silylation With A Hydrogen-Bonded Template
    作者:Maji,Arun; Guin,Srimanta; Feng,Sheng; Dahiya,Amit; Singh,Vikas Kumar; Et Al
    参考文献:Angewandte Chemie 日期:2017 卷标:56(47) 页码:14903-14907]

    148-24-3 = 938-33-0
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Tetrahydrofuran; Rt; Overnight,Rt
    标题:Preparation Of 1,2,3,4-Tetrahydroquinoline Derivative Useful In The Treatment Of Diabetes
    参考文献:World Intellectual Property Organization]

    53899-17-5 = 938-33-0
    反应条件:1.1 Reagents: Potassium Tert-Butoxide,Oxygen Solvents: 2-Methyl-2-Butanol; 10 - 24 H,120 °C
    标题:Kotbu/o2 Mediated Dehydrogenation Of N-Heterocycles,Alcohols
    作者:Fu,Xuegang; Wang,Yue; Liu,Liu; Li,Caifeng; Huang,Lin; Et Al
    参考文献:Chemistryselect 日期:2022 卷标:7(30)]

    148-24-3 = 938-33-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; Rt; Overnight,Rt
    标题:Development Of Highly Selective Dual Mode Chromogenic And Fluorogenic Chemosensor For Bi3+ Ions
    作者:Saravana Kumar,S.; Selva Kumar,R.; Ashok Kumar,S. K.
    参考文献:Journal Of Molecular Structure 日期:2020 卷标:1212]

    504-63-2 = 938-33-0
    反应条件:1.1 Catalysts: Bismuth Cobalt Carbonate Oxide (Bi2Co(Co3)O2); 48 H,150 °C
    标题:Sustainable Synthesis Of Azobenzenes,Quinolines And Quinoxalines Via Oxidative Dehydrogenative Couplings Catalysed By Reusable Transition Metal Oxide-Bi(Iii) Cooperative Catalysts
    作者:Kocsis,Marianna; Baan,Kornelia; Otvos,Sandor B.; Kukovecz,Akos; Konya,Zoltan; Et Al
    参考文献:Catalysis Science & Technology 日期:2023 卷标:13(10) 页码:3069-3083]

    148-24-3 = 938-33-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; Rt; 24 H,Reflux
    标题:Iridium-Catalyzed Site-Selective Borylation Of 8-Arylquinolines
    作者:Hassan,Mirja Mahamudul Md; Hoque,Emdadul Md; Dey,Sayan; Guria,Saikat; Roy,Brindaban; Et Al
    参考文献:Synthesis 日期:2021 卷标:53(18) 页码:3333-3342]

    148-24-3 = 938-33-0
    反应条件:1.1 Solvents: Acetonitrile; 30 Min,Rt
    标题:Polymer Supported Synthesis Of Bioactive Heterocyclic Compounds
    作者:More,Uttam B.; Narkhede,Hemant P.; Raut,Changdeo N.; Mahulikar,Pramod P.
    参考文献:Indian Journal Of Heterocyclic Chemistry 日期:2009 卷标:19(1) 页码:43-46]

    148-24-3 = 938-33-0
    反应条件:1.1 Catalysts: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Dimethylformamide; 10 Min,220 °C
    标题:A Continuous Base-Catalyzed Methylation Of Phenols With Dimethyl Carbonate
    作者:Tilstam,Ulf
    参考文献:Organic Process Research & Development 日期:2012 卷标:16(5) 页码:1150-1153]

    148-24-3 = 938-33-0
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; Cooled; 8 H,Rt1.2 Reagents: Ethanol; Rt
    标题:Tetradentate Cyclometal Platinum(Ii) And Palladium(Ii) Complex Luminescent Material Containing Quinoline Structural Unit And Application Thereof
    参考文献:World Intellectual Property Organization]

    148-24-3 = 938-33-0
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; Rt; 8 H,Cooled1.2 Reagents: Ethanol
    标题:Metal Platinum(Ii) And Palladium(Ii) Complex Containing Quinoline Structural Unit And Bridging Structure,Organic Light-Emitting Device And Display Or Lighting Device Containing The Same
    参考文献:China]

    148-24-3 = 938-33-0
    反应条件:1.1 Reagents: Sodium Hydride Catalysts: Sodium Iodide Solvents: Dimethylformamide; Rt; Overnight,Rt1.2 Reagents: Ethanol; Rt
    标题:5/6/6-Ring-Fused Tetradentate Cyclometallated Platinum(Ii) Complex Phosphorescent Material Based On Quinoline Unit Structure And Application Thereof In Electroluminescence Devices
    参考文献:China]

    611-33-6 = 938-33-0
    反应条件:1.1 Reagents: Sodium Tert-Butoxide Catalysts: [3,6-Dimethoxy-2′,4′,6′-Tris(1-Methylethyl)[1,1′-Biphenyl]-2-Yl]Bis(1,1-Dimethyl...,Palladium(1+),[2′-(Amino-Kn)[1,1′-Biphenyl]-2-Yl-Kc][[3,6-Dimethoxy-2′,4′,6′-Tr... Solvents: 1,4-Dioxane; 20 H,50 °C
    标题:Mild And General Palladium-Catalyzed Synthesis Of Methyl Aryl Ethers Enabled By The Use Of A Palladacycle Precatalyst
    作者:Cheung,Chi Wai; Buchwald,Stephen L.
    参考文献:Organic Letters 日期:2013 卷标:15(15) 页码:3998-4001]

    148-24-3 = 938-33-0
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Dimethylformamide,Tetrahydrofuran; 12 H,Rt1.2 Reagents: Water
    标题:Preparation Of Tetracyclic Xanthene Amino Acid Derivatives For Treatment Of Viral Diseases
    参考文献:World Intellectual Property Organization
📜3-碘-8-甲氧基喹啉置于tris-(Dibenzylideneacetone)Dipalladium(0),四丁基氯化铵,Sodium Benzenesulfonate,Potassium Carbonate,2-二环己膦基-2'-(N,N-二甲胺)-联苯体系中,用 N-甲基吡咯烷酮 作为反应溶剂,化学反应 15.0H,反应生成 8-甲氧基喹啉
参考文献:Palladium-Catalyzed Desulfitative Arylation Of 3-Haloquinolines With Arylsulfinates
标题:Palladium-Catalyzed Desulfitative Arylation Of 3-Haloquinolines With Arylsulfinates
摘要:3-Haloquinolines Can Be Functionalized Via A Palladium-Catalyzed Desulfitative Coupling Of Arylsulfinates. This Method Tolerates Substitution Upon The Aromatic Ring And Shows Good Selectivity Toward Variously Substituted Aromatic Rings. (C) 2013 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetlet.2013.01.018

海关参考信息

专利信息


专利号:US-10717718-B2
优先权日:2015-11-17
标 题:5-azido-5-deoxy-2 :3-isopropylidene-D-arabinose compounds; their method of manufacture and their use for the synthesis of ARA-N3, KDO-N3 and 4EKDO-N3
发明人：VAUZEILLES BORIS; MAS PONS JORDI; BARON AURÈLIE
权利人:CENTRE NAT RECH SCIENT
摘要:Disclosed are new compounds of formulae: n nWherein: R 1 and R 2 can be independently H; a C 1 to C 6 alkyl including methyl, ethyl, propyl, butyl; aryl including phenyl, para-methoxyphenyl; or R 1 ,R 2 together with the carbon C-6 can be a cyclopentylidene or cyclohexylidene; each of these groups being substituted or not; and R 3 can be a C 1 to C 6 alkyl including methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl; or aryl including phenyl, methylphenyl, ethylphenyl, each of these groups being substituted or not. The invention also relates to their method of manufacture and their use for the synthesis of Ara-N 3 , Kdo-N 3 and 4eKdo-N 3 .

专利号:US-7105617-B2
优先权日:2003-02-06
标题:Metal 8-hydroxyquinoline-functionalized polymers and related materials and methods of making and using the same
发明人：WECK MARCUS; MEYERS AMY
权利人:GEORGIA TECH RES INST
摘要:This invention relates to the synthesis of Mq n -containing monomeric compounds, comprising a polymerizable moiety, an Mq n -moiety, and an optional chemical spacer therebetween, wherein q, in each instance, comprises an 8-hydroxyquinoline residue, M is a metal such as Mg, Zn, Al, Ga, or In, and n is 2 or 3 as the valence of the metal requires. For example, the polymerization of Znq 2 - or Alq 3 -containing monomers, in the presence or absence of a co-monomer, provided a Znq 2 - or Alq 3 -containing polymer, which retained the optical properties of Znq 2 or Alq 3 in solution, respectively. The Mq n -containing polymers may be used in, among other things, the fabrication of light-emitting diodes (LEDs).

专利号:US-8030496-B2
优先权日:2005-02-17
标 题:Intermediate compound for synthesis of viridiofungin a derivative
发明人：KATO TATSUYA; KIMURA NOBUAKI; MIZUTANI AKEMI; MAKINO TOSHIHIKO; KAWASAKI KENICHI; FUKUDA HIROSHI; KOMIYAMA SUSUMU; TSUKUDA TAKUO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:A method whereby a compound having HCV replication inhibitory activity and desired optical activity can be synthesized selectively and at high yield in a small number of steps by using a compound having a specific chiral auxiliary as a starting compound is provided. n A compound represented by the formula (1-8): n n n n n n n n n n n n wherein Y represents a group represented by the following formula: n n n n n n n n n n n n n n n n Q represents a protected carbonyl group; D represents —(CH 2 ) m —R′, etc.; and n represents an integer of 0 to 10.

专利号:US-9206196-B1
优先权日:2014-07-11
标 题 :Derivatives of benzoxazino quinoline, benzoxazino isoquinoline and processes for their preparation
发明人：BIJU AKKATTU THANKAPPAN; BHUNIA ANUP; SHANMUGAM DHANASEKARAN
权利人:COUNCIL SCIENT IND RES
摘要:Novel benzoxazino quinoline derivatives of Formula (I) and benzoxazino isoquinoline derivatives of Formula (II) are provided: n n n n n n n n n n Also provided is a transition-metal-free multicomponent reaction of arynes, N-heterocycles, and carbonyl compounds leading to the diastereoselective synthesis of benzoxazino quinoline derivatives of Formula (I) and benzoxazino isoquinoline derivatives of formula (II) in good yields proceeding via 1,4-zwitterionic intermediates. The compounds possess anti-malarial activity.

专利号:US-4908439-A
优先权日:1988-09-16
标题:Synthesis of intermediate useful in the preparation of nojirimycin and related compounds
发明人：ANZEVENO PETER
权利人:MERRELL DOW PHARMA
摘要:5-Amino-5-deoxy-1,2-O-isopropylidene- alpha -D-glucofuranose is conveniently prepared by a hydride reduction of 5-azido-5-deoxy-1,2-O-isopropylidene- alpha -D-glucuronolactone and can readily be converted to nojirimycin, deoxynojirimycin or homonojirimycin.

专利号:US-9388345-B2
优先权日:2012-07-03
标题:Hydrocarbon synthesis methods, apparatus, and systems
发明人：MCNEFF CLAYTON V; MCNEFF LARRY C; NOWLAN DANIEL THOMAS; YAN BINGWEN; GREUEL PETER G
权利人:SARTEC CORP
摘要:Embodiments of the invention include apparatus and systems for hydrocarbon synthesis and methods regarding the same. In an embodiment, the invention includes a process for creating a hydrocarbon product stream comprising reacting a reaction mixture in the presence of a catalyst inside of a reaction vessel to form a product mixture, the reaction mixture comprising a carbon source and water. The temperature inside the reaction vessel can be between 450 degrees Celsius and 600 degrees Celsius and the pressure inside the reaction vessel can be above supercritical pressure for water. In an embodiment, the invention includes an extrusion reactor system for creating a hydrocarbon product stream. The temperature inside the extrusion reactor housing between 450 degrees Celsius and 600 degrees Celsius. Pressure inside the reaction vessel can be above supercritical pressure for water. Other embodiments are also included herein.

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合成参考文献


摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 73.
摘要:Shehzad, A.; Vu, H. D.; Devi, K.; Bissinger, B. R. G.; Wiesenfeldt, M. P., Science of Synthesis: Dearomatizations, (2026) .
摘要:Nairoukh, Z.; Ding, H.; Hu, M., Science of Synthesis: Dearomatizations, (2026) .
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