专利号:US-9896336-B2 优先权日:2008-06-11 标 题:Bromine-facilitated synthesis of fluoro-sulfur compounds 发明人:WINTER ROLF 权利人:AVANTBIO CORP 摘要:Described herein are methods for the bromine-facilitated synthesis of fluoro-sulfur compounds, that include SF 4 , SF 5 Cl, SF 5 Br and SF 6 . The methods described herein generally require lower temperature and pressure, produce higher yields, require less time, do not use corrosive or costly reactants and solvents that are commonly used in the synthesis of the fluoro-sulfur compounds, and do not produce deleterious waste products when compared to previously-used methods.
专利号:WO-2024110994-A1 优先权日:2022-11-25 标题 :A process for the preparation of ledipasvir 发明人:GANGARAJULA SUDHAKAR; CHENNAM RAMU; KUMARAGURU THENKRISHNAN; BABURAO RODE HARIDAS; MADDI REDDY SRIDHAR; CHADA REDDY RAJI; GHOSH SUBHASH 权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S 摘要:The present disclosure relates to process for the preparation of Ledipasvir (I) or of its pharmaceutically acceptable salts. The present disclosure also provides novel intermediates (IV–XI) that are used in the synthesis of Ledipasvir. The main strategies of the present invention are late-stage functionalization such as difluorination and cyclopropanation of the key intermediates of Ledipasvir (I). (Formula (I))
专利号:US-6225511-B1 优先权日:1990-10-26 标题 :Synthesis of fluorinated ethers 发明人:CHAMBERS OWEN ROSS; SIMPSON RODERIC NIGEL FRASER 权利人:RHONE POULENC CHEMICALS 摘要:Fluorinated ethers of the formula:wherein R is hydrogen, fluorine, alkyl of 1 to 6 carbon atoms, or fluoroalkyl of 1 to 6 carbon atoms, R' is hydrogen, alkyl of 1 to 6 carbon atoms, or fluoroalkyl of 1 to 6 carbon atoms, and R'' is fluorine, alkyl of 1 to 6 carbon atoms or fluoroalkyl of 1 to 6 carbon atoms are prepared by fluorinating a corresponding ether of formula:with a solid transition metal fluoride fluorinating agent such as cobaltic fluoride.
专利号:US-6958415-B2 优先权日:2003-11-14 标 题 :Synthesis of pentafluorosulfuranyl arylenes 发明人:LAL GAURI SANKAR; MINNICH KRISTEN ELAINE 权利人:AIR PROD & CHEM 摘要:A new route has been found leading to the formation of pentafluorosulfuranyl arylenes. In its broadest aspect the process comprises:n effecting dehydrohalogenation or dehydrogenation of a pentafluorosulfuranyl cycloaliphatic compound represented by either of the structures: n n wherein R 1-5 are H, halogen, C 1-10 alkyl, C 1-10 alkoxy, C 1-10 thionyl, C 1-10 alkyl ether, aryl and substituted aryl, thioether, sulfonyl, carboalkoxy, alkylamino, arylamino, alkylphosphoryl, alkylphosphonyl, arylphosphonyl, arylphosphoryl, and mixtures thereof and X is a halogen atom to form the pentafluorosufuranyl arylene represented by the structures: n n wherein R 1 -R 5 are as represented above.
专利号:US-2019359485-A1 优先权日:2008-06-11 标 题:Bromine-Facilitated Synthesis of Fluoro-Sulfur Compounds
专利号:US-2010086853-A1 优先权日:2008-10-07 标题 :Positive electrode materials for lithium ion batteries having a high specific discharge capacity and processes for the synthesis of these materials
摘要:Kordnezhadian, R.; De Borggraeve, W. M.; Ismalaj, E., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 2. 摘要:Yerien, D. E.; Barata-Vallejo, S.; Postigo, A., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 9. 摘要:Wang, X.; Hu, J., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2. 摘要:Xiao, D.; Du, Y., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .