CAS: 7073-99-6; 1-Bromo-2-(Tert-Butyl)Benzene

该化合物是一种有机化合物,其芳香结构特征为1溴-2-之三-丁基苯,包括一个以溴原子和三丁基组物替代的苯环;溴原子的存在引入了卤素功能,可增强化合物在各种化学反应中的抗反应性,如核阴性替代物等; 叔丁基元素组体,体积大,影响分子的...

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上下游产品

tert-butylbenzene 3-bromo-4-(tert-butyl)aniline tert-butyl-aniline; hydr°Chloride3-bromo-4-tert-butyl-aniline; hydr°Chloride 2-bromo-1-tert-butyl-4-nitrobenzene tert-butyl-4-nitro-benzene1-bromo-2-tert-butyl-4-nitro-benzene tert-butyl-phenyl)-propan-2-ol2-(2-tert-butyl-phenyl)-propan-2-ol [2-(1,1-dimethylethyl)phenyl]trimethylsilane 2-tert.-Butyloxy-1-tert.-butyl-benzol

合成工艺路线路线简述

    📜2-叔丁基苯酚置于吡啶,(1,1'-Bis(Diphenylphosphino)Ferrocene)Palladium(II) Dichloride,三乙胺,Copper(Ll) Bromide体系中,用 1,4-二氧六环,甲醇,二氯甲烷,水 作为反应溶剂,化学反应 26.0H,反应生成 1-溴-2-叔丁基苯
    参考文献:Methods And Compositions For Treating Infection
    标题:Methods And Compositions For Treating Infection
    摘要:本文提供了用于治疗或预防感染的组合物和方法.

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    专利信息


    专利号:US-9328061-B2
    优先权日:2012-03-01
    标题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols
    发明人:HOVEYDA AMIR H; SILVERIO DANIEL L; PILYUGINA TATIANA; TORKER SEBASTIAN; ROBBINS DANIEL
    权利人:TRUSTEES BOSTON COLLEGE
    摘要:The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.

    专利号:US-6762329-B2
    优先权日:1997-10-06
    标题 :Diaryl ether condensation reactions
    发明人:MARCOUX JEAN-FRANCOIS; DOYE SVEN; BUCHWALD STEPHEN
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:One aspect of the present invention relates to novel reaction conditions that allow the efficient synthesis of diaryl ethers from arenes bearing a leaving group and arenols under relatively mild conditions. Another aspect of the present invention relates to the dramatic effects of acidic activators on Ullmann-type couplings involving electron-poor and/or relatively insoluble substrates.

    专利号:US-2015057451-A1
    优先权日:2012-03-01
    标 题 :Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols

    专利号:US-7671085-B2
    优先权日:2002-11-15
    标 题 :Non-steroidal farnesoid X receptor modulators and methods for the use thereof
    发明人:DOWNES MICHAEL R; EVANS RONALD M
    权利人:SALK INST FOR BIOLOGICAL STUDI
    摘要:The efficient regulation of cholesterol synthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accordingly, the development of potent, selective, small molecule agonists, partial agonists, and antagonists of FXR would be an important step in further deconvoluting FXR physiology. In accordance with the present invention, the identification of novel potent FXR activators is described. Two derivatives of invention compounds, bearing stilbene or biaryl moieties, contain members that are the most potent FXR agonists reported to date in cell-based assays. These compounds are useful as chemical tools to further define the physiological role of FXR as well as therapeutic leads for the treatment of diseases linked to cholesterol, bile acids and their metabolism and homeostasis.

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    合成参考文献


    摘要:Keay, B. A., Science of Synthesis, (2002) 4, 685.
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