CAS: 6556-11-2; Rel-(1R,2R,3S,4R,5S,6S)-Cyclohexane-1,2,3,4,5,6-Hexayl Hexanicotinate

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CAS号87-89-8 肌醇 | CAS号20260-53-1 盐酸烟酰氯 | CAS号59-67-6 烟酸 | CAS号10400-19-8 烟酰氯 | CAS号59-67-6 烟酸

专利信息

专利号:US-2009232915-A1
优先权日:2008-03-14
标 题 :Mixtures with a collagen synthesis boosting action
发明人：SCHMAUS GERHARD; FRANKE HELGE; LANGE SABINE
权利人:SYMRISE GMBH & CO KG
摘要:The invention relates to synergistically active, ternary mixtures which boost collagen synthesis and to the uses thereof, in particular for slowing down skin ageing and for wound healing of damaged skin. The invention furthermore relates to the use of the ternary mixtures according to the invention for treating the oral cavity and pharynx, and in particular therein for preventing and slowing down periodontitis, for building up periodontal connective tissue and for preventing and treating infections in the oral cavity and for wound healing in the oral cavity.

专利号:US-2005282781-A1
优先权日:2004-06-18
标 题 :Compositions of stable bioactive metabolites of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids
发明人：GHOSAL SHIBNATH
权利人:GHOSAL SHIBNATH
摘要:An invention that adduces cogent evidence to establish that oxygenated dibenzo-α-pyrones (DBPs and their conjugates), the major bioactives of shilajit (Ayurvedic vitalizer), have their origin, at least partly, in EPA and DHA. Earlier research has shown that, in mammals, C-20 PUFAs are metabolized by oxygenases and other enzymes to produce short-lived prostaglandins, leukotrienes and thromboxanes that bind to specific G-protein-coupled receptors and signal cellular responses, e.g., inflammation, vasodilation, blood pressure, pain etc. But never before it was suggested/shown that C 20:5n-3 (and C 22:6 n-3 ) PUFAs, e.g., EPA (and DHA), are transformed into stable aromatic metabolites, DBPs, which elicit a large array of bioactivities in the producer organisms and also control the synthesis and metabolism of arachidonate-derived prostaglandins. The major beneficial effects attributed to EPA and DHA are now found to be largely contributed by DBPs and their aminoacyl conjugates and the dibenzo-α-pyrone-chromoproteins (DCPs). Because of the highly unstable nature of EPA and DHA, when administered, they are metabolized into a large array of uncontrolled products, several of which are systemically undesirable. By contrast, DBPs, because of their stability, perform the biological response modifier (BRM) functions in a directed and sustained way. Many of the biological effects of DBPs described in this invention, were earlier attributed to EPA and DHA,—the precursors of DBPs.

专利号:WO-2006097348-A1
优先权日:2005-03-15
标 题:Use of agents such as nonpolymeric nitric oxide donors for making the lips full again and/or colouring the lips
发明人：CALS-GRIERSON MARIE-MADELEINE
权利人:OREAL; CALS-GRIERSON MARIE-MADELEINE
摘要:The invention relates in particular to the cosmetic use (i) of at least one agent for promoting the production of NO in and/or on the lips, chosen from nitric oxide NO donors or precursors; nonpolymeric NO releasers; and NO synthase synthesis and/or activity stimulators; or (ii) of other agents for promoting microcirculation in the skin, chosen from potassium channel openers; calcium channel blockers; phosphodiesterase inhibitors; flavonoids; vasodilator peptides that are not NO donors; temperature modulators; agents for promoting the stimulation and/or maintenance of angiogenesis; agents for promoting the stimulation of endothelial cell proliferation; agents for promoting endothelial cell migration; and mixtures thereof, in a makeup and/or care composition for the lips, as an agent for naturally making the lips full again and/or naturally coloring the lips. It also relates to specific care and/or makeup compositions for the lips containing said agent, and also to a cosmetic process aimed at making the lips naturally full and/or colored, using said compositions .

专利号:US-10099998-B2
优先权日:2015-02-04
标 题 :Compound, and separation method, synthesis method and use thereof
发明人：DUAN ZHENWEN; GUO SHUREN; LI XUEMEI
权利人:BEIJING PEKING UNIV WBL BIOTECH CO LTD
摘要:The invention relates to new compounds as well as a separation method, a synthetic method and use thereof. It is demonstrated by an assay on activity that the compound has an activity of inhibiting an HMG-CoA reductase. In addition, the invention also relates to a derivative of the compound.

专利号:JP-2005225870-A
优先权日:2004-01-16
标 题 :Agents for promoting the synthesis of vascular endothelial nitric oxide and / or maintaining / improving blood levels of endothelial nitric oxide

专利号:US-2013131310-A1
优先权日:2010-07-28
标题 :Drug-ligand conjugates, synthesis thereof, and intermediates thereto
发明人：KANE JOHN; LANCASTER THOMAS M; ZION TODD C
权利人:KANE JOHN; LANCASTER THOMAS M; ZION TODD C
摘要:The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: (I) wherein each of X, Alk, and W are as defined and described herein.