CAS: 626-08-4; 3-Thioxo-3,4-Dihydro-1,2,4-Triazin-5(2H)-One

该化合物是一个环环,具有三联苯环特征,其特征为三联氮原子和两个碳原子.该化合物因其三联氧组而显著,有助于其反应和在各种化学反应中的潜在应用.该化合物在室温中表现为固态,在极地溶剂中溶解.该二联体的存在具有独特的化学特性,使其可以用于制药和农用化学品.其结构结构允许与生物系统进行潜在互动,从而可以导致各种生物活动.此外,该化合物还可能因其红外线和硫磷形式的存在而表现出调味,从而影响其再活动性和稳定性.

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上下游产品

5-oxo-3-thioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid 2-[2-(aminothioxomethyl)hydrazinyl]acetic acid ethyl glyoxylate thiosemicarbazone 3-propargylmercapto-1,2,4-triazin-5(2H)-one 6-azauracil -1,2,4-triazine-3,5-diamineN,N'-Bis2-(3,4-dimethoxyphenyl)ethyl-1,2,4-triazine-3,5-diamine 3-But-3-ynylsulfanyl-2H-[1,2,4]triazin-5-one 3,5-dithioxo-2,3,4,5-tetrahydrotriazine

合成工艺路线路线简述

    📜Glyoxylsaeure-Thiosemicarbazon置于sodium Hydroxide体系中,化学反应生成 6-杂氮-2-硫脲嘧啶
    参考文献:Gut,Collection Of Czechoslovak Chemical Communications,1958,Vol. 23,P. 1588,1589 Anm.,1590
    标题:Gut,Collection Of Czechoslovak Chemical Communications,1958,Vol. 23,P. 1588,1589 Anm.,1590

    专利信息


    专利号:WO-2011040984-A1
    优先权日:2009-10-02
    标 题:Synthesis of decitabine

    专利号:US-4082911-A
    优先权日:1975-02-24
    标题 :Process for the preparation of nucleosides
    发明人：VORBRUGGEN HELMUT
    权利人:SCHERING AG
    摘要:The use of trialkylsilyl ester catalysts in place of Lewis acid or Friedel-Crafts catalysts in nucleoside synthesis gives increased yields and a simplified working-up process for recovering the nucleoside product.

    专利号:CA-2747755-C
    优先权日:2009-10-02
    标题 :Synthesis of decitabine

    专利号:AU-2010291893-A1
    优先权日:2008-10-03
    标 题 :Synthesis of decitabine

    专利号:AU-2010291893-A8
    优先权日:2008-10-03
    标 题 :Synthesis of decitabine

    专利号:US-5750676-A
    优先权日:1995-04-03
    标题 :Process for preparing nucleosides with unprotected sugars
    发明人：VORBRUEGGEN HELMUT; KROLIKIEWICZ KONRAD; BENNUA-SKALMOWSKI BAERBEL
    权利人:HOECHST AG
    摘要:A novel process for nucleoside synthesis, which process comprises reacting the free sugar with heterocyclic bases in the presence of silylating agents in an inert solvent containing a Lewis acid.

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    主要参考文献

    参考标题:Synthesis Of Adamantane Derivatives. Lviii. Reaction Of 1-Adamantyl Chloride With Some Heterocyclic Unsaturated Silanes.
    作者:Tadashi Sasaki,Akira Nakanishi,Masatomi Ohno
    摘要:Various Silylated Heterocycles Having Amide Functionality Were Treated With 1-Adamantyl Chloride (1) In The Presence Of A Lewis Acid To Give The Corresponding N-Adamantylated Heterocycles. If α-Position To The Reacting Lactim Nitrogen Was Substituted, The Reaction No Longer Occurred, Or The Adamantylation Occurred At The Position Other Than The Expected Nitrogen. These Facts Are Attributed To A Steric Blocking Effect Of The α-Substituent. While The Same Treatment Of The Thioamide 46 Gave The S-Adamantylated Product, 48 And 51 Afforded In Contrast The N- And S-Adamantylated Products, Respectively ; This Result Can Be Explained In Terms Of Steric Effect. Analogously, Silylated 2-Pyrazolines And Triazoles Were Adamantylated At Nitrogen. The Reactions Of 2-Trimethylsilylthiophene, Furan And -Pyridine With 1 Failed To Give Site-Selective Monoadamantylation.

    合成参考文献


    摘要:K. Kalfus, Collect. Czech. Chem. Commun. 33, 2962 (1968).
    摘要:J. Gut, M. Prystas and J. Jonas, Collect. Czech. Chem. Commun. 26, 986 (1961).
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