CAS: 59489-71-3; 2-Amino-5-Bromopyrazine

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3-氨基-6-溴吡嗪-2-甲酸置于1,2,3,4-四氢萘体系中,化学反应生成 2-氨基-5-溴吡嗪
参考文献:Pyrazine Chemistry. Iv. Bromination Of 2-Amino-3-Carbomethoxypyrazine
标题:Pyrazine Chemistry. Iv. Bromination Of 2-Amino-3-Carbomethoxypyrazine
摘要:
DOI:10.1021/ja01176A058

专利信息

专利号:US-2024010638-A1
优先权日:2020-11-13
标题:Improved synthesis of crac channel inhibitors
发明人：STAUDERMAN KENNETH; DUNN MICHAEL; OLMSTEAD KAY
权利人:CALCIMEDICA INC
摘要:Provided herein is an improved synthetic method for the production of CRAC channel inhibitors. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.

专利号:US-2022056053-A1
优先权日:2019-05-06
标 题:Synthesis of crac channel inhibitors
发明人：STAUDERMAN KENNETH A; DUNN MICHAEL; WHITTEN JEFFREY P; ROGERS EVAN
权利人:CALCIMEDICA INC
摘要:A convergent synthetic method for the production of CRAC channel inhibitors is described herein. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.

专利号:US-2011054174-A1
优先权日:2009-08-28
标 题:Process for the preparation of a glucokinase activator compound
发明人：BACHMANN STEPHAN; FETTES ALEC; IDING HANS; WIRZ BEAT; ZUTTER ULRICH
权利人:BACHMANN STEPHAN; FETTES ALEC; IDING HANS; WIRZ BEAT; ZUTTER ULRICH
摘要:The present invention relates to a process for the preparation of a compound of formula I, n n n n n n n n n n wherein R 1 is C 1-6 -alkyl and R 2 is hydrogen or halogen. n (R)-2-phenyl propionic acid derivatives of formula I are key intermediates in the synthesis of 5-substituted-pyrazine or pyridine glucokinase activators of the formula Xa, n n n n n n n n n n which have the potential to be useful for the treatment and/or prophylaxis of type II diabetes.

专利号:EP-3103803-B1
优先权日:2008-10-27
标 题 :Intermediates for the synthesis of mtor kinase inhibitors

专利号:WO-2020227312-A1
优先权日:2019-05-06
标 题:Synthesis of crac channel inhibitors

专利号:CN-117946013-B
优先权日:2024-01-25
标题:One-pot synthesis of 5,6-dihalogenated-3-aminopyrazine-2-carboxylic acid methyl ester