合成目标产物 2-(Methylthio)Ethanol 主要起始原料 Methyl Mercaptan And 2-Chloroethanol
(文献来源)合成步骤主要原料 Methyl Mercaptan 和 2-Chloroethanol
1-碘-2-甲硫基乙烷置于水体系中,用 乙醇 作为反应溶剂,化学反应生成 2-甲硫基乙醇 参考文献:Leaving Group Rate Ratios In Solvolytic Displacement Reactions. Effect Of Neighboring Sulfur 标题:Leaving Group Rate Ratios In Solvolytic Displacement Reactions. Effect Of Neighboring Sulfur 摘要: DOI:10.1021/jo00387A036
专利号:US-2012029226-A1 优先权日:2009-02-06 标题:Method for the synthesis of chiral alpha-aryl propionic acid derivatives 发明人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE 权利人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE 摘要:The present invention provides a method for the synthesis of optically pure α-aryl propionic acid derivatives comprising subjecting the corresponding racemic α-aryl propionic acid derivatives to high sheer or impact forces, such as grinding.
专利号:US-5866721-A 优先权日:1996-12-27 标题 :Process for separating the product gas mixture from the catalytic synthesis of methyl mercaptan 发明人:HOFEN WILLI; BOECK WOLFGANG; RAUTENBERG STEPHAN; SAUER JOERG; ARNTZ DIETRICH; GOEDECKE RALF; TAUGNER WOLFGANG; SONNENSCHEIN RAYMUND 权利人:DEGUSSA 摘要:A process for separating the product gas mixture from the catalytic synthesis of methyl mercaptan. Because of improved separation of the product gas mixture into its components, less hydrogen sulfide and methyl mercaptan are lost in discharging the inert gases than in the known process. The inert gases can be burned without after-treatment of the exhaust gas. Likewise, the process water that is discharged is less contaminated with polysulfides.
专利号:US-6172226-B1 优先权日:1993-12-22 标 题:Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions 发明人:COULL JAMES M; EGHOLM MICHAEL; HODGE RICHARD P; ISMAIL MOHAMED; RAJUR S B 权利人:PERSEPTIVE BIOSYSTEMS INC 摘要:A method is disclosed for preparing novel PNA synthons having protecting groups capable of removal under mild conditions. The PNA synthons are prepared by coupling novel N-substituted nucleobase intermediates having carbamate protection of the exocyclic amino group of the heterocycle to an amino protected backbone or an amino protected backbone ester of the amino acid N-(2-aminoethyl)-glycine. By the method of this invention, the resultant PNA synthons can have orthogonal protection of the carbamate protected nucleobase and the amino protected backbone. The PNA synthons are useful in the synthesis of peptide nucleic acids (PNAs) and other oligomers such as PNA-DNA chimeras, and may be used in automated synthesizers. Novel compositions of matter are also disclosed. In addition, a guanine PNA synthon having selective carbamate protection of the exocyclic 2-amino group with the C6 carbonyl group unprotected is disclosed.
专利号:US-2013243770-A1 优先权日:2005-10-14 标 题:Treating diabetes using inhibitors of il-1 发明人:LAU JESPER 权利人:NOVO NORDISK AS 摘要:The present invention describes a method of treating diabetes or metabolic syndrome with a compound that inhibits (a) IL-1, (b) the synthesis of IL-1, or (c) the release of IL-1.
专利号:US-5637757-A 优先权日:1995-04-11 标 题 :One-pot synthesis of ring-brominated benzoate compounds 发明人:HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH 权利人:GREAT LAKES CHEMICAL CORP 摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.
专利号:US-2004053999-A1 优先权日:1997-09-17 标题 :Novel compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
[参考文献]: Matthew C Mackenzie, Et Al. Synthesis Of Poly(Meth)Acrylates With Thioether And Tertiary Sulfonium Groups By Arget Atrp And Their Use As Sirna Delivery Agents. Biomacromolecules. 2015 Jan 12;16(1):236-45.
合成参考文献
摘要:Garrido-Barros, P.; Funes-Ardoiz, I.; Farràs, P.; Gimbert-Suriñach, C.; Maseras, F.; Llobet, A., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 67. 参考文献:10.1016/j.bmcl.2004.04.020|10.1016/s0960-894x(04)00518-9 摘要:Geldenhuys WJ, Lockman PR, McAfee JH, Fitzpatrick KT, Van der Schyf CJ, Allen DD. Molecular modeling studies on the active binding site of the blood–brain barrier choline transporter. Bioorganic & Medicinal Chemistry Letters. 2004 Jun;14(12):3085–92. doi: 10.1016/j.bmcl.2004.04.020. 参考文献:10.1007/s11306-021-01849-5 摘要:Cao P, Wu S, Guo W, Zhang Q, Gong W, Li Q, Zhang R, Dong X, Xu S, Liu Y, Shi S, Huang Y, Zhang Y. Precise pathological classification of non-small cell lung adenocarcinoma and squamous carcinoma based on an integrated platform of targeted metabolome and lipidome. Metabolomics. 2021 Nov 03;17(11):98. doi: 10.1007/s11306-021-01849-5.