CAS: 51786-11-9; 2-Chloro-3-Hydroxybenzonitrile

该化合物是一种有机化合物,其特点是用氯组,氢氧基组和硝酸盐组替代的苯环,其特点是芳香结构,有助于其稳定性和回活动;该氯组的存在具有极性,提高了其在极溶剂中的溶解性,而氢氧基可参与氢联结,影响其物理特性,如沸点和熔点等;硝基子组,其特点是存在碳三重氮,具有额外的再活性,使化合物在各种化学合成和应用中有用.2-Chroloro-3-Hyoxybontrile可能展示生物活动,使其对药物研究感兴趣.其合成通常涉及一种合适的前体的氯化,随后是氢氧化和硝化步骤.与许多有机化合物一样,在处理时应采取安全防范措施,因为它可能构成健康风险或环境危害.

英文名称2-Chloro-3-Hydroxybenzonitrile
中文名称2-氯-3-羟基苯甲腈
IUPAC名称2-chloro-3-hydroxybenzonitrile
其它别名2 - 氯 - 3 - 氰基苯酚; Benzonitrile, 2-Chloro-3-Hydroxy-
CAS编号51786-11-9
MFCD编号:MFCD11848763
分子式:C7H4ClNO分子量:153.57
产品CID: 1507820
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: DERLNEQRYBEGFW-UHFFFAOYSA-N
InChI=1S/C7H4ClNO/c8-7-5(4-9)2-1-3-6(7)10/h1-3,10H
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

CAS号853331-52-9 2-氯-3-甲氧基苯甲腈 | CAS号56962-10-8 2-氯-3-羟基苯甲醛 | CAS号211172-52-0 2-氨基-3-羟基苯甲腈 | CAS号873-62-1 3-羟基苯腈 | CAS号129298-23-3 3-羟基-2-硝基苄腈

合成工艺路线路线简述

合成目标产物 Benzonitrile, 2-Chloro-3-Hydroxy- 主要起始原料 2-Chloro-3-Hydroxybenzaldehyde 97
(文献来源)合成步骤主要原料 2-Chloro-3-Hydroxybenzaldehyde 97

📜3-氰基苯酚置于palladium On Activated Charcoal Sodium Nitrate,亚硝酸特丁酯,硫酸,氢气,Copper Dichloride,Sodium Nitrite体系中,用二氯甲烷,乙酸乙酯,乙腈作为反应溶剂,化学反应 56.0H,反应生成 2-氯-3-羟基苯甲腈
参考文献:Evaluation Of Potent And Selective Small-Molecule Antagonists For The Cxcr2 Chemokine Receptor
标题:Evaluation Of Potent And Selective Small-Molecule Antagonists For The Cxcr2 Chemokine Receptor
摘要:N,N'-Diarylureas Were Prepared,And The Structure-Activity Relationship Relative To The Cxcr2 Receptor Was Examined. This Led To The Identification Of A Potent And Highly Selective Cxcr2 Antagonist,Which In Addition Was Shown To Be Functionally Active Both In Vitro Against Human Neutrophils And In Vivo In Rabbit Models Of Ear Edema And Neutropenia.
DOI:10.1021/jm034248L