CAS: 5030-61-5; 2,3-Dibromo-1,4-Dimethoxybenzene

该化合物是一种溴化芳香化合物,由1和4个位置的两个甲氧基组组成,2和3个位置的溴替代物为2和3个位置的溴替代物,这种结构赋予了适合进一步功能化的再活动性,使其成为有机合成中的宝贵中间体,特别是在复杂的芳香系统的准备过程中.电子施食的甲氧基组增强了其在电益替代反应中的效用,而溴原子则为交错反应提供了场所,如铃木或斯蒂尔联动,其晶晶状固体形式和界定的分子重量(295.94克/摩尔)确保合成应用中的处理和声一测量精度一致.适合用于制药,农用化学品和材料科学研究.

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物理性质

MSDS等安全信息

上下游产品

CAS号1266379-51-4 2,3-dibromo-4-m... | CAS号74-88-4 碘甲烷 | CAS号1207434-10-3 2,3-二溴-1,4-二碘苯 | CAS号1266379-49-0 2,3-dibromo-1-i... | CAS号1266379-50-3 2-(2,3-dibromo-... | CAS号564471-05-2 2,3-dibromo-1,4... | CAS号5030-58-0 Z-Ala-Ala-Phe-OH

合成工艺路线路线简述

    📜2,3-Dibrom-6-Nitro-Hydrochinon-Dimethylaether置于盐酸,Tin(Ll) Chloride体系中,化学反应 2.0H,反应生成 1,4-二甲氧基-2,3-二溴苯
    参考文献:Schill,G.,Chemische Berichte,1966,Vol. 99,P. 714-715
    标题:Schill,G.,Chemische Berichte,1966,Vol. 99,P. 714-715

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    专利信息


    专利号:US-2021214303-A1
    优先权日:2018-05-30
    标 题:Scorpion venom benzoquinone derivatives and uses thereof
    发明人：ZARE RICHARD NEIL; VEYTIA-BUCHELI JOSE IGNACIO; NORIEGA EDSON NORBERTO CARCAMO; ELUMALAI GNANAMANI; SATHYAMOORTHI SHYAM; POSSANI POSTAY LOURIVAL DOMINGOS; BANERJEE SHIBDAS; HERNANDEZ PANDO ROGELIO ENRIQUE
    权利人:UNIV LELAND STANFORD JUNIOR; UNIV MEXICO NAC AUTONOMA; INSTITUTO NAC DE CIENCIAS MEDICAS Y NUTRICION SALVADOR ZUBIRAN
    摘要:Provided are colored 1,4-benzoquinone compounds obtained by oxidation of precursor molecules from the venom of the scorpion Diplocentrus melici (Diplocentridae family). Schemes for the chemical synthesis of these compounds using reagents commercially available are also provided. Biological assays show that the red compound (3,5-dimethoxy-2-(methylthio)cyclohexa-2,5-diene-1,4-dione) is very effective at killing Staphylococcus aureus and that the blue compound (5-methoxy-2,3-bis(methylthio)cyclohexa-2,5-diene-1,4-dione) has remarkable activity against Mycobacterium tuberculosis. The blue compound is effective against multi-drug-resistant tuberculosis (MDR-TB) and is not detrimental to lung epithelium. Both compounds were found to be cytotoxic to human neoplastic cell lines and to mononuclear cells (PBMCs).

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    主要参考文献

    参考标题:Efficient And Complementary Methods Offering Access To Synthetically Valuable 1,2-Dibromobenzenes
    作者:Vincent Diemer,Frédéric R. Leroux,Françoise Colobert |发布日期:2011.1
    摘要:In Particular, Reactions Based On The Intermediate Formation Of Benzynes. This Report Describes Short Sequences For The Synthesis Of Various Derivatives Based On Regioselective Bromination, Ortho-Metalation, And Halogen/metal Permutations. 1,2-Dibromo-3-Iodobenzene (2F), 1,2-Dibromo-4-Iodobenzene (4C), And 2,3-Di-Bromo-1,4-Diiodobenzene (5E) Act As Intermediates In These Syntheses.

    合成参考文献


    参考文献:10.1038/s41429-025-00809-8
    摘要:Gallegos-Monterrosa R, Cid-Uribe JI, Delgado-Prudencio G, Pérez-Morales D, Banda MM, Téllez-Galván A, Carcamo-Noriega EN, Garza-Ramos U, Zare RN, Possani LD, Bustamante VH. Blue benzoquinone from scorpion venom shows bactericidal activity against drug-resistant strains of the priority pathogen Acinetobacter baumannii. J Antibiot (Tokyo). 2025 Mar;78(4):235–45.
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