CAS: 4977-62-2; Ethyl 2-Acetamido-2-Cyanoacetate

相似化合物

1068-90-2 1008711-58-7 54681-67-3

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cyano-nitro-acetic acid ethyl ester acetic anhydride ethyl-2-amin°Cyano acetate ethyl cyanoglyoxylate-2-oxime(rac)-2-amino-3-furan-2-yl-propionic acid rac-(+/-)-β-benzimidazol-2-ylalanine (RS)-ethyl-2-acetamido-2-cyano-3-phenylpropanoate 2-acetylamino-2-cyano-4-phenyl-butyric acid ethyl ester

2-肟氰乙酸乙酯置于sodium Dithionite,碳酸氢钠,三乙胺体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 5.0H,反应生成 N-乙酰基-2-氰基甘氨酸乙酯
参考文献:2-取代的三环恶唑并[5,4-D]嘧啶库:设计,合成和细胞毒性活性
标题:2-取代的三环恶唑并[5,4-D]嘧啶库:设计,合成和细胞毒性活性
摘要:我们报告了 49 个新合成的三环恶唑并[5,4-D]嘧啶库的设计,合成路线和细胞毒性.缩合嘧啶酮由 5-氨基恶唑-4-羧酸乙酯结构单元构成.使用天然存在的麦金唑啉酮生物碱构建了三环系统,重点关注恶唑环 C-2 位的分子多样性.合成的化合物在体外针对一组人类癌细胞系进行了评估,包括 Mcf-7(乳腺),Hela(宫颈)和 A549(肺).结果表明,在恶唑环的 C-2 位取代卤素相关的芳香片段可作为有希望的抗癌药物候选者.
DOI:10.1002/jhet.4401

专利信息

专利号:US-3969284-A
优先权日:1973-05-24
标 题 :Amino acid derivatives of chloromethylated polymers and methods of making the same
发明人：GRAY DON N
权利人:OWENS ILLINOIS INC
摘要:The application discloses polymers and methods of making same in which a chlorine atom of a chloromethyl pendant group of a polymer such as a chloromethylated copolymer of styrene and divinylbenzene is substituted with a derivative of malonic acid having a protected amino group on the alpha-carbon atom and two carboxyl groups or precursors thereof to form, via several steps, the alpha-amino acid derivative of the starting polymer. These polymers are used, for instance, as ion exchange resins, as substrates for affinity chromotography, and as a starting resin for solid peptide synthesis. The resultant polymer is also used as a starting material to make a polymer with a pendant group that is a derivative of oxazolidone-2,5-dione, substituted at the 4-position. These polymers are used, for example, as the matrix for solid phase peptide synthesis and as the starting resin for solid phase peptide degradation.

专利号:US-3985715-A
优先权日:1973-05-24
标 题:Oxazolidone derivatives of chloromethylated polymers and methods of making the same
发明人：GRAY DON N
权利人:OWENS ILLINOIS INC
摘要:The application discloses polymers and methods of making same in which a chlorine atom of a chloromethyl pendant group of a polymer such as a chloromethylated copolymer of styrene and divinylbenzene is substituted with a derivative of malonic acid having a protected amino group on the alpha-carbon atom and two carboxyl groups or precursors thereof to form, via several steps, the alpha-amino acid derivative of the starting polymer. These polymers are used, for instance, as ion exchange resins, as substrates for affinity chromotography, and as a starting resin for solid peptide synthesis. The resultant polymer is also used as a starting material to make a polymer with a pendant group that is a derivative of oxazolidone-2,5-dione, substituted at the 4-position. These polymers are used, for example, as the matrix for solid phase peptide synthesis and as the starting resin for solid phase peptide degradation.

专利号:US-2479662-A
优先权日:1944-12-19
标题 :Synthesis of amino acids
发明人：ALBERTSON NOEL F; SYDNEY ARCHER
权利人:WINTHROP STEARNS INC