CAS: 24067-17-2; (4-Nitrophenyl)Boronic Acid

该化合物是一种含有硝基苯基组的碳酸衍生物,通常用作有机合成和交叉相交反应的多用途中间体,其电子退出式硝基子组可增强反应性,使其在铃木-米亚乌拉的双子化合物组合中特别有用.该化合物在标准条件下具有良好稳定性,在普通有机溶剂中可溶解,便于实验室处理.它作为药物研究,材料科学和传感器开发的主要试剂,因为它能够形成稳定的双醇酯.其晶状形式确保精确合成应用的纯度.

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上下游产品

CAS号636-98-6 4-硝基碘苯 | CAS号73183-34-3 双戊酰二硼 | CAS号586-78-7 对溴硝基苯 | CAS号98-80-6 苯硼酸 | CAS号100-00-5 对硝基氯苯 | CAS号108-24-7 乙酸酐 | CAS号850693-33-3 trifluoro(4-nit... | CAS号4282-47-7 2-(4-硝基苯基)吡啶 | CAS号402-67-5 间氟硝基苯 | CAS号350-46-9 对氟硝基苯 | CAS号100-01-6 对硝基苯胺 | CAS号92-93-3 4-硝基联苯 | CAS号171364-83-3 4-硝基苯硼酸频哪醇酯 | CAS号92-89-7 4'-硝基-[1,1'-联苯]-4-羧酸 | CAS号619-72-7 对硝基苯甲腈 | CAS号19725-49-6 4H-1-BENZOPYRAN... | CAS号3034-09-1 2-(4-Nitropheny...

合成工艺路线路线简述

  • 合成目标产物 4-Nitrophenylboronic Acid 主要起始原料 Methanol And Borane-Diisopropylamine And 1-Bromo-4-Nitrobenzene
  • (文献来源)合成步骤主要原料 Methanol 和 Borane-Diisopropylamine 和 1-Bromo-4-Nitrobenzene
4-硝基苯胺 以 水,N,N-二甲基甲酰胺 用作溶剂,化学反应 0.53H,反应生成4-硝基苯基硼酸
参考文献:轻松合成(杂)芳基硼酸
标题:轻松合成(杂)芳基硼酸
摘要:重氮盐和二硼酸之间空前的自发反应性已经被揭示出来,从而导致直接由(杂)芳基胺合成多功能的芳基硼酸.这种快速反应(总共35分钟)可耐受各种官能团,并且在非常温和的条件下进行.研发了反应机理的根本性质.
Doi:10.1002/chem.201402487

专利信息


专利号:US-8981092-B2
优先权日:2008-09-19
标题 :Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity
发明人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO
权利人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds, n nor pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:CN-119350141-A
优先权日:2024-10-23
标题:Method for green synthesis of aromatic ketone and biphenyl based on quartz sand solid-phase system

专利号:CN-116490201-A
优先权日:2020-07-02
标题 :Inhibitors of YAP/TAZ-TEAD tumor proteins, their synthesis and use

专利号:US-2007275968-A1
优先权日:2004-09-07
标 题 :Substituted Biphenyl Derivative
发明人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
权利人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
摘要:The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: n nwherein n R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.

专利号:US-8178559-B2
优先权日:2004-12-30
标 题:Organic compounds
发明人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

专利号:EP-2927215-A1
优先权日:2014-04-03
标题:Copper chelators
发明人:RUSSO VINCENZO
权利人:FARMA DERMA S R L
摘要:The present invention relates to a new class of chemical compounds of structure 6,7-dimethoxy-1,2,3,4-tetra-hydro-isoquinoline having therapeutic action, processes for the synthesis thereof and formulations containing said derivatives. More particularly, the present invention relates to ligand compounds adapted for chelating the free cupric ion in the serum of patients suffering from Alzheimer's and Wilson's diseases.
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主要参考文献

参考标题:Synthesis Of New Heteroaryl Substituted Morpholine Tagged Triazines And Evaluation Of Their Cytotoxic Activity
作者:Sivaprasad Kasturi,Sujatha Surarapu,Srinivas Uppalanchi,Hasitha Shilpa Anantaraju,Shubham Dwivedi,Perumal Yogeeswari,Krishna S. Ethiraj,Jaya Shree Anireddy |发布日期:2018.1.30
摘要:Background: In The Present Study, New Triazine Derivatives 3, 4, 5, 6, 8 And 10 Were Synthesized Starting From Readily Available Cyanuric Chloride 1 Via Nucleophilic Displacement With Morpholine Followed By Suzuki Or Stille Coupling Reactions And Then The Thermal Displacement Of Chlorine Atom With Diverse Substituted Amines. Methods: All Synthesized Compounds Were Screened For Their Cytotoxic Activity

合成参考文献


摘要:Black, D. A.; Fagnou, K., Science of Synthesis, (2010) 45, 575.
摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 263.
摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 199.
摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 291.
摘要:Kimura, T., Science of Synthesis Knowledge Updates, (2016) 2, 454.
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