CAS: 2356-16-3; Triethyl 2-Fluoro-2-Phosphonoacetate

相似化合物

30094-32-7 7071-12-7 124755-24-4

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CAS号401-55-8 溴氟乙酸乙酯 | CAS号122-52-1 亚磷酸三乙酯 | CAS号867-13-0 磷酰基乙酸三乙酯 | CAS号401-58-1 氟碘乙酸乙酯 | CAS号65094-25-9 DIETHYL (DIBROM... | CAS号7071-02-5 potassium salt ... | CAS号401-56-9 氯氟乙酸乙酯 | CAS号762-04-9 亚磷酸二乙酯 | CAS号541-41-3 氯甲酸乙酯 | CAS号2284-70-0 2-Butenoicacid,... | CAS号547-63-7 异丁酸甲酯 | CAS号26928-12-1 2-fluoro-3-(4-m... | CAS号30094-32-7 2-(二乙氧基磷酰基)-2-氟乙酸 | CAS号101560-16-1 ethyl 2-fluoro-... | CAS号113307-25-8 ethyl 2-cyclope... | CAS号20397-61-9 (Z)-Alpha-氟肉桂酸 | CAS号1479-22-7 2-氟-3-氧代-3-苯丙酸乙酯 | CAS号760-80-5 2-氟代丙烯酸乙酯

二乙基[二溴(氟)甲基]膦酸酯置于盐酸,正丁基锂,乙醇,水体系中,用 四氢呋喃,正己烷,二氯甲烷 用作溶剂,化学反应生成2-氟-2-磷酰基乙酸三乙酯
参考文献:Preparation Of Triethyl 2-Fluoro-2-Phosphonoacetate
标题:Preparation Of Triethyl 2-Fluoro-2-Phosphonoacetate
摘要:Triethyl 2-Fluoro-2-Phosphonoacetate Was Prepared In One Step From Dibromofluoromethylphosphonate And Ethyl Chloroformate.
Doi:10.1080/00397919408011733

专利信息

专利号:WO-0200681-A1
优先权日:2000-06-27
标题 :20-fluoro-17(20)-vinyl steroids as inhibitors of c17-20-lyase and 5-alpha reductase
发明人：PEET NORTON P; WEINTRAUB PHILIP M; BURKHART JOSEPH P; GATES CYNTHIA A
权利人:AVENTIS PHARMA INC; PEET NORTON P; WEINTRAUB PHILIP M; BURKHART JOSEPH P; GATES CYNTHIA A
摘要:The invention related to 20κ-fluoropregna-4,17(20)-dien-3-on-21-oic acid ethyl ester, 20κ-fluoro-3β-hydroxypregna-4,17(20)-dien-21-oic acid ethyl ester, 20κ-fluoro-21-hydroxypregna-4,17(20)-dien-3-one, 20κ-fluoropregna-4,17(20)-dien-3β,21-diol and related compounds and to compositions incorporating these compounds, as well as the inhibition of C17,20 lyase, 5α-reductase and C17-hydroxylase, and to the use of these compounds in the treatment of androgen and estrogen mediated or dependent disorders, including benign prostatic hyperplasia, prostate cancer, breast cancer and DHT-mediated disorders such as acne and hirsutism. Treatment of disorders related to the over synthesis of cortisol, for example, Cushing's Syndrome are also included. The treatment of androgen-dependent disorders also includes a combination therapy with known androgen-receptor antagonists, such as flutamide. The compounds of the invention have general formulae (I).

专利号:US-11046648-B2
优先权日:2017-03-01
标 题 :Transition metal-catalyzed protodecarboxylation of α-halo-acrylic acid derivatives
发明人：DANG MAI THI QUYNH; HAMPEL THOMAS ARMIN; KOCH SANDRA; NORDSTROM FREDRIK LARS; REEVES JONATHAN TIMOTHY; REICHEL CARSTEN; SCHOERER MARVIN; STANGE CHRISTIAN; VOLCHKOV IVAN N; ZHONG LI; ZIMMERMANN UWE JOHANNES
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to a method for the synthesis of a halo olefin of formula (I)wherein Hal, R1, R2, R3, R4, X and Y are as defined herein, or a salt thereof.

专利号:US-4808749-A
优先权日:1980-10-01
标 题:Cyclopropane carboxylic esters and acids
发明人：MARTEL JACQUES; TESSIER JEAN; TECHE ANDRE
权利人:ROUSSEL UCLAF
摘要:Novel esters in all possible isomeric forms of the formula ##STR1## wherein R is selected from the group consisting of (a) optionally unsaturated alkyl of 1 to 8 carbon atoms and optionally unsaturated cycloalkyl or cycloalkyl-alkyl of 3 to 8 carbon atoms optionally substituted with at least one member of the group consisting of halogen, --OH, --SH, --OR', --SR', --NO 2 , ##STR2## --CN, --SO 3 H, --PO 4 H 2 , ##STR3## --SO 2 AlK 2 , --SO 3 AlK 3 , aryl optionally substituted with at least one member of the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --CF 3 , --OCF 3 , --SCF 3 and ##STR4## R' is alkyl of 1 to 8 carbon atoms, R' and R'' are individually selected from the group consisting of hydrogen and alkyl of 1 to 8 carbon atoms, AlK 1 , AlK 2 and AlK 3 are individually alkyl of 1 to 18 carbon atoms, (b) aryl of 6 to 14 carbon atoms optionally substituted with at least one substitutent selected from the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --OCF 3 , --CF 3 and --SCF 3 and (c) heterocycle optionally substituted with at least one member of the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --CF 3 , --OCF 3 and --SCF 3 , B is selected from the group consisting of optionally unsaturated alkyl of 1 to 18 carbon atoms, optionally unsaturated cycloalkyl of 3 to 18 carbon atoms and the remainder of an alcohol used in synthesis of pyrethrinoid esters, X is halogen and the ethylenic double bond may have Z or E geometry having parasitic activity, especially insecticidal acaricidal and nematocidal activity.

专利号:US-6413951-B2
优先权日:2000-06-27
标题:20-fluoro-17(20)-vinyl steroids
发明人：PEET NORTON P; WEINTRAUB PHILIP M; BURKHART JOSEPH P; GATES CYNTHIA A
权利人:AVENTIS PHARMA INC
摘要:The invention relates to 20ξ-fluoropregna-4,17(20)-dien-3-on-21-oic acid ethyl ester, 20ξ-fluoro-3beta-hydroxypregna-5,17(20)-dien-21-oic acid ethyl ester, 20ξ-fluoro-21-hydroxypregna-4,17 (20)-dien-3-one, 20ξ-fluoropregna-5,17(20)-dien-3beta,21-diol and related compounds and to compositions incorporating these compounds, as well as the inhibition of C17,20 lyase, 5alpha-reductase and C17-hydroxylase, and to the use of these compounds in the treatment of androgen and estrogen mediated or dependent disorders, including benign prostatic hyperplasia, prostate cancer, breast cancer and DHT-mediated disorders such as acne and hirsutism. Treatment of disorders related to the over synthesis of cortisol, for example, Cushing's Syndrome are also included. The treatment of androgen-dependent disorders also includes a combination therapy with known androgen-receptor antagonists, such as flutamide. The compounds of the invention have the following general formulae:

专利号:US-5856530-A
优先权日:1996-05-14
标题:Antipicornaviral compounds and methods for their use and preparation
发明人：WEBBER STEPHEN E; DRAGOVICH PETER S; PRINS THOMAS J; REICH SIEGFRIED H; LITTLE JR THOMAS L; LITTLEFIELD ETHEL S; MARAKOVITS JOSEPH T; BABINE ROBERT E; BLECKMAN TED M
权利人:AGOURON PHARMA
摘要:Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.

专利号:US-6362166-B1
优先权日:1996-05-14
标 题 :Antipicornaviral compounds and methods for their use and preparation
发明人：WEBBER STEPHEN E; DRAGOVICH PETER S; PRINS THOMAS J; REICH SIEGFRIED H; LITTLE JR THOMAS L; LITTLEFIELD ETHEL S; MARAKOVITS JOSEPH T; BABINE ROBERT E; BLECKMAN TED M
权利人:AGOURON PHARMA
摘要:Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.