CAS: 22236-10-8; 4-(Difluoromethoxy)Aniline

上下游产品

CAS号1544-86-1 4-(二氟甲氧基)硝基苯 | CAS号128140-82-9 4-二氟甲氧基碘苯 | CAS号7440-66-6 锌标准溶液 | CAS号4472-44-0 2-氯-4,6-二甲基嘧啶 | CAS号22236-11-9 N-(4-二氟甲氧基苯基)乙酰胺 | CAS号1173435-64-7 BMS-665053 | CAS号827031-10-7 N-[4-(difluorom... | CAS号871586-76-4 6-二氟甲氧基-2,3,4,9... | CAS号51679-46-0 2-{[4-(二氟甲氧基)苯基... | CAS号638192-10-6 Benzenamine, 4-...

4-二氟甲氧基碘苯置于copper(L) Iodide,维生素 C体系中,用 氨 用作溶剂,化学反应 18.0H,以98%的收率获得4-二氟甲氧基苯胺
参考文献:铜(i)催化氨在液态氨中的胺化
标题:铜(i)催化氨在液态氨中的胺化
摘要:液态氨(lnh 3)由铜(i)盐/抗坏血酸体系催化生成伯芳族胺,收率好至极好.所需的低浓度催化剂和易于分离的产品表明该方法具有潜在的工业应用价值.通常用于类似金属催化反应的配体是无效的.液态氨中碘苯的胺化速率是铜(i)催化剂浓度的一级.在25oc的氨水中4-取代的碘苯胺的胺化反应中小的hammettρ= 0.49表明,C-i键在过渡态结构中没有明显断裂,并且在芳基中有一小段负电荷产生环,其与限速的铜离子的氧化加成相容.
Doi:10.1021/jo301204T

专利信息

专利号:US-4517130-A
优先权日:1982-04-22
标 题 :Substituted amino acid process
发明人：BAER TED A
权利人:ZOECON CORP
摘要:An improved process for preparing substituted amino acids and lower alkyl esters thereof, and intermediates therefor, comprising reacting a substituted aniline, HCN and an aldehyde to form a nitrile, converting the nitrile to an imidate salt with a strong acid and an alcohol, hydrolyzing in situ the imidate salt to the ester with addition of water, and optionally converting the ester to the salt or free acid. The acids are useful intermediates in the synthesis of pesticides.