CAS: 21703-08-2; 1-(3,4-Dichlorophenyl)Biguanide, Hcl

该化合物是一种合成重氮化物衍生物,可用于制药和化学研究,其结构特征是二氯联苯组,附于一个重氮化物主骨,增强了其活性和结合特性;盐酸盐形式提高了溶性性和稳定性,使之适合实验和工业用途;该化合物因其潜在的生物活动,常常用于研制抗微生物剂和抗糖尿病剂;其高纯度和明确定义的化学特性确保合成和分析应用的一贯性能;研究人员认为它具有有机合成的多功能,在研究药用化学的结构活动关系方面发挥作用.

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CAS号13344-99-5 1,3,5-Triazine-...

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    📜3,4-二氯苯胺,二聚氰胺置于盐酸体系中,用 水 用作溶剂,化学反应 0.17H,反应生成1-(3,4-二氯苯基)双胍 盐酸盐
    参考文献:Structural Insights Into The Development Of Cycloguanil Derivatives Astrypanosoma Bruceipteridine-Reductase-1 Inhibitors
    标题:Structural Insights Into The Development Of Cycloguanil Derivatives Astrypanosoma Bruceipteridine-Reductase-1 Inhibitors
    摘要:Cycloguanil Is A Known Dihydrofolate-Reductase (Dhfr) Inhibitor,But There Is No Evidence Of Its Activity On Pteridine Reductase (Ptr),The Main Metabolic Bypass To Dhfr Inhibition In Trypanosomatid Parasites. Here,We Provide Experimental Evidence Of Cycloguanil As An Inhibitor Of Trypanosoma Brucei Ptr1 (Tbptr1). A Small Library Of Cycloguanil Derivatives Was Developed,Resulting In 1 And 2A Having Ic50 Values Of 692 And 186 Nm,Respectively,Toward Tbptr1. Structural Analysis Revealed That The Increased Potency Of 1 And 2A Is Due To The Combined Contributions Of Hydrophobic Interactions,H-Bonds,And Halogen Bonds. Moreover,In Vitro Cell-Growth-Inhibition Tests Indicated That 2A Is Also Effective On T. Brucei. The Simultaneous Inhibition Of Dhfr And Ptr1 Activity In T. Brucei Is A Promising New Strategy For The Treatment Of Human African Trypanosomiasis. For This Purpose,1,6-Dihydrotriazines Represent New Molecular Tools To Develop Potent Dual Ptr And Dhfr Inhibitors.
    Doi:10.1021/acsinfecdis.8B00358

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    参考标题:An Efficient Synthesis Of 1-Aryl-4,6-Diamino-1,2-Dihydro- 1,3,5-Triazines
    作者:Neungruthai Saesaengseerung,Tirayut Vilaivan,Yodhathai Thebtaranonth |发布日期:2002.1.1
    摘要:Abstract 1-Aryl-4,6-Diamino-1,2-Dihydro-1,3,5-Triazines Bearing Diverse Substituents At C2 And On The Aromatic Ring Have Been Synthesized In Good Yield From An Acid-Catalyzed Reaction Between Corresponding Arylbiguanide And Carbonyl Compound In The Presence Of Triethyl Orthoacetate As A Water Scavenger.

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    参考DOI号:10.1021/acsinfecdis.8b00358
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