CAS: 21668-77-9; 1,3-Propanedisulfonic Acid

上下游产品

CAS号109-80-8 1,3-丙二硫醇 | CAS号109-64-8 1,3-二溴丙烷 | CAS号20686-91-3 1,3-Propanedisu... | CAS号1120-71-4 1,3-丙烷磺内酯 | CAS号20686-91-3 1,3-Propanedisu... | CAS号4720-58-5 1,2,6-oxadithia... | CAS号6274-90-4 1,3-Propanedisu...

📜1,3-丙二硫醇置于hof* Ch3Cn体系中,用 二氯甲烷 用作溶剂,以90%的收率获得伊罗地塞
参考文献:使用hof.ch 3 Cn将硫醇和二硫化物普遍,快速且高收率地氧化为磺酸和亚磺酸
标题:使用hof.ch 3 Cn将硫醇和二硫化物普遍,快速且高收率地氧化为磺酸和亚磺酸
摘要:使用hof.ch 3 Cn将硫醇和二硫化物氧化为相应的磺酸和亚磺酸.这种氧化适合各种硫醇和二硫化物,并在温和的条件下以短的反应时间和高收率进行.
Doi:10.1016/j.Tetlet.2007.09.083

专利信息

专利号:US-10323010-B2
优先权日:2015-07-20
标题 :Methods of chemical synthesis of substituted 10H-phenothiazine-3,7-diamine compounds
发明人：STOREY JOHN MERVYN DAVID; LARCH CHRISTOPHER PAUL; KEMP STEVEN JOHN; CLUNAS SCOTT; NICOLL SARAH LOUISE; GIBBARD HELEN SARAH; SIMPSON MICHAEL; SINCLAIR JAMES PETER; MARSHALL COLIN
权利人:WISTA LAB LTD
摘要:The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease.

专利号:US-5872244-A
优先权日:1994-09-02
标 题:3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
发明人：HIATT ANDREW C; ROSE FLOYD
权利人:HIATT ANDREW C; ROSE FLOYD D
摘要:A method for the stepwise creation of phosphodiester bonds between desired nucleosides resulting in the synthesis of polynucleotides having a predetermined nucleotide sequence by preparing an initiation substrate containing a free and unmodified 3'-hydroxyl group; attaching a mononucleotide selected according to the order of the predetermined nucleotide sequence to the 3'-hydroxyl of the initiating substrate in a solution containing a catalytic amount of an enzyme capable of catalyzing the 5' to 3' phosphodiester linkage of the 5'-phosphate of the mononucleotide to the 3'-hydroxyl of the initiating substrate, wherein the mononucleotide contains a protected 3'-hydroxyl group, whereby the protected mononucleotide is covalently linked to the initiating substrate and further additions are hindered by the 3'-hydroxyl protecting group. Methods in which a mononucleotide immobilized on a solid support is added to a free polynucleotide chain are also disclosed.

专利号:US-5763594-A
优先权日:1994-09-02
标 题:3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
发明人：HIATT ANDREW C; ROSE FLOYD
权利人:HIATT ANDREW C; ROSE FLOYD D
摘要:A method for the stepwise creation of phosphodiester bonds between desired nucleosides resulting in the synthesis of polynucleotides having a predetermined nucleotide sequence by preparing an initiation substrate containing a free and unmodified 3'-hydroxyl group; attaching a mononucleotide selected according to the order of the predetermined nucleotide sequence to the 3'-hydroxyl of the initiating substrate in a solution containing a catalytic amount of an enzyme capable of catalyzing the 5' to 3' phosphodiester linkage of the 5'-phosphate of the mononucleotide to the 3'-hydroxyl of the initiating substrate, wherein the mononucleotide contains a protected 3'-hydroxyl group, whereby the protected mononucleotide is covalently linked to the initiating substrate and further additions are hindered by the 3'-hydroxyl protecting group. Methods in which a mononucleotide immobilized on a solid support is added to a free polynucleotide chain are also disclosed.

专利号:US-5808045-A
优先权日:1994-09-02
标 题 :Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
发明人：HIATT ANDREW C; ROSE FLOYD
权利人:HIATT ANDREW C; ROSE FLOYD D
摘要:A method for the stepwise creation of phosphodiester bonds between desired nucleosides resulting in the synthesis of polynucleotides having a predetermined nucleotide sequence by preparing an initiation substrate containing a free and unmodified 3'-hydroxyl group; attaching a mononucleotide selected according to the order of the predetermined nucleotide sequence to the 3'-hydroxyl of the initiating substrate in a solution containing a catalytic amount of an enzyme capable of catalyzing the 5' to 3' phosphodiester linkage of the 5'-phosphate of the mononucleotide to the 3'-hydroxyl of the initiating substrate, wherein the mononucleotide contains a protected 3'-hydroxyl group, whereby the protected mononucleotide is covalently linked to the initiating substrate and further additions are hindered by the 3'-hydroxyl protecting group. Methods in which a mononucleotide immobilized on a solid support is added to a free polynucleotide chain are also disclosed.

专利号:WO-2017013174-A1
优先权日:2015-07-20
标 题 :Methods of chemical synthesis of substituted 10h-phenothiazine-3,7-diamine compounds

专利号:US-2018208565-A1
优先权日:2015-07-20
标题:Methods of chemical synthesis of substituted 10h-phenothiazine-3,7-diamine compounds