CAS: 199006-54-7; Fmoc-Phe(4-Me)-Oh

相似化合物

204260-38-8 80102-26-7 4599-47-7

上下游产品

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 4-methyl-L-phenylalanine 4-tolyl iodide 34H52N6O5C34H52N6O5 2O-W-F-I-F(4-Me)-H(1-Bzl)-NH2 2O-W-F(4-Me)-I-F-H(1-Bzl)-NH2

(S)-2-(1,3-Dioxoisoindolin-2-yl)-3-(P-Tolyl)Propanoic Acid置于sodium Carbonate,一水合肼体系中,用 甲醇,水 用作溶剂,化学反应 27.0H,反应生成Fmoc-L-4-甲基苯丙氨酸
参考文献:无需安装外来指导基团的α-氨基酸的配体激活β-C-H芳基化
标题:无需安装外来指导基团的α-氨基酸的配体激活β-C-H芳基化
摘要:在本文中,我们报道了吡啶型配体使α-氨基酸的酸导向β-C(sp 3)-H芳基化反应.该反应不需要安装外源性指导基团,具有可扩展性,并且可以通过三个步骤制备受fmoc保护的非天然氨基酸.吡啶型配体对于这种新的c(sp 3)-H芳基化的发展至关重要.
Doi:10.1002/anie.201610580

专利信息

专利号:US-8410028-B2
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

专利号:US-2007042401-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries

专利号:US-2012245040-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries

专利号:US-2009062147-A1
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries

专利号:US-7972994-B2
优先权日:2003-12-17
标 题 :Methods for synthesis of encoded libraries

专利号:US-7935658-B2
优先权日:2003-12-17
标 题 :Methods for synthesis of encoded libraries