CAS: 169905-10-6; 2-(Chloromethyl)-3,4-Dimethoxypyridine

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CAS号72830-08-1 2-羟甲基-3,4-二甲氧基吡啶 | CAS号72830-07-0 3,4-二甲氧基-2-甲基吡啶... | CAS号102625-99-0 2-acetoxymethyl... | CAS号7152-24-1 2-(甲硫基)苯并咪唑 | CAS号107512-18-5 2-[(3,4-dimetho... | CAS号102625-64-9 泮托拉唑硫酸盐

3,4-二甲氧基-2-甲基吡啶-N-氧化物置于sodium Hydroxide,氯化亚砜,溶剂黄146体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 4.0H,反应生成泮托拉唑的中间体
参考文献:2-[((2-吡啶基甲基)亚磺酰基]-1H-噻吩并[3,4-D]咪唑.一类新型的胃h + / K(+)-Atpase抑制剂.
标题:2-[((2-吡啶基甲基)亚磺酰基]-1H-噻吩并[3,4-D]咪唑.一类新型的胃h + / K(+)-Atpase抑制剂.
摘要:合成2-[((2-吡啶基甲基)亚磺酰基]噻吩并咪唑类化合物,并研究其作为胃h + / K(+)-Atpase的潜在抑制剂.已发现两种可能的噻吩并咪唑系列的[3,4-D]异构体在体外和体内都是有效的胃酸分泌抑制剂.结构活性关系表明,特别是在吡啶部分的4位具有额外的电子要求特性的亲脂性烷氧基,苄氧基和苯氧基取代基与未取代的噻吩并[3,4-D]咪唑结合会导致具有高活性的化合物.非常好的化学稳定性.噻吩并[3,4-D]咪唑部分的各种取代方式导致较低的生物活性.选择了七氟丁氧基衍生物萨维拉唑(hoe 731,5D)进行进一步开发,目前正在临床评估中.
Doi:10.1021/jm00081A004

专利信息

专利号:WO-2005044815-A1
优先权日:2003-11-10
标题 :Method for the synthesis of pantoprazole and intermediates

专利号:ES-2201936-B1
优先权日:2003-11-10
标 题 :PROCEDURE FOR SYNTHESIS OF PANTOPRAZOL AND INTERMEDIATES.

专利号:WO-2006049486-A1
优先权日:2004-11-08
标题:A PREPARATION METHOD FOR SUBSTITUTED 2-(2-PYRIDYLMETHOYLSULPHINYL)-l-H-BENZIMID AZOLES
发明人：RAJNIKANT VYAS JANMEJAY; MALLIK YADAV KASA
权利人:DISHMAN PHARMACEUTICALS AND CH; RAJNIKANT VYAS JANMEJAY; MALLIK YADAV KASA
摘要:The invention relates to a process for the preparation of a substituted 2-(2-pyridylmethylsulphinyl)-l-H-benzimidazole involving the reaction of a corresponding 2-(2-pyridylrnethylthio)-l-H-benzirnidazole compound with a hypohalite oxidation agent in the presence of a phase transfer catalyst, wherein the reaction involves a biphasic reaction mixture containing an aqueous and an organic phase. The reaction can immediately succeed the formation of said 2-(2-pyridylmethylthio)-l-H-benzimidazole compound in a one pot synthesis, in order to avoid time-consuming and costly purification steps. Overoxidation, leading to sulphone impurities, is thus avoided and yields improved. Hence, the invention also relates to a substituted 2-(2-pyridylmethylsulphinyl)-l-H-benzimidazole containing less than 0.2 wt% sulphone impurities.

专利号:US-2017143665-A1
优先权日:2014-02-26
标题:Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents

专利号:CN-118324772-A
优先权日:2024-02-29
标 题:Synthesis method and intermediate of furan [3,2-b ] pyridine derivative