CAS: 13734-40-2; (2S,3R)-3-(Tert-Butoxy)-2-((Tert-Butoxycarbonyl)Amino)Butanoic Acid

相似化合物

201217-86-9 117106-20-4 138797-71-4

上下游产品

CAS号1070-19-5 Carbonazidic ac... | CAS号4378-13-6 O-叔丁基-L-苏氨酸

📜N-重氮基氨基甲酸叔-丁基酯,O-叔丁基-L-苏氨酸置于hydroxide体系中,化学反应生成N-叔丁氧羰基-O-叔丁基-L-苏氨酸
参考文献:通过ph调节反应改善叔丁氧羰基氨基酸的合成
标题:通过ph调节反应改善叔丁氧羰基氨基酸的合成
摘要:游离氨基酸或其部分保护的衍生物与叔丁氧基羰基叠氮化物的反应在控制的ph值下可产生高收率的叔丁氧基羰基衍生物.甚至位阻氨基酸也能平稳反应.通过选择ph值,可以轻松确定快速,广泛实施的最有利条件.
Doi:10.1002/jlac.19677020123

专利信息

专利号:US-4965343-A
优先权日:1988-01-28
标题 :Method of peptide synthesis
发明人：FELIX ARTHUR M; FOURNIER ALAIN; DANHO WALEED
权利人:HOFFMANN LA ROCHE
摘要:A method for the solid phase synthesis of multi-sulfated peptides comprising coupling side-chain unprotected hydroxyamino acids to the peptide chain utilizing benzotriazol-1-yl-oxy-tris (dimethyl)-phosphonium hexafluorophosphate (BOP) as a coupling reagent.

专利号:US-7038037-B2
优先权日:2002-06-20
标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds
发明人：MAIER MARTIN A; GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated oligomeric compound for therapeutic or prophylactic delivery is also disclosed.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-2025052163-A1
优先权日:2023-09-07
标 题:2-amino-n-(benzo[d]thiazol-2-ylsulfonyl)-3-hydroxybutanamide derivatives acting as a threonyl-t-rna synthetase inhbitors for the treatment of malaria
发明人：JIRGENSONS AIGARS; BOLSAKOVA JEKATERINA; BOBROVS RAITIS; VARACEVA LARISA
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:Representatives of 2-amino-N-(benzo[d]thiazol-2-ylsulfonyl)-3-hydroxybutanamide with general formula (I) show potency to inhibit malarial threonyl-tRNA synthetase (ThrRS) in low micromolar to nanomolar concentrations. As such they can be applied as compounds for prevention or treatment of malaria.

专利号:US-2004006203-A1
优先权日:2002-06-20
标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds

专利号:CN-113135979-A
优先权日:2020-01-18
标题 :A method for solid-phase synthesis of peptides