CAS: 13477-53-7; 4-Amino-2-Hydroxybutanoic Acid

相似化合物

40371-51-5 40371-51-5 40371-50-4

上下游产品

CAS号59712-12-8 4-amino-2-hydro... | CAS号56-12-2 4-氨基丁酸 | CAS号3025-96-5 4-乙酰氨基丁酸 | CAS号57413-15-7 methyl 4-amino-... | CAS号107-95-9 β-丙氨酸 | CAS号15166-68-4 3-羟基-2-吡咯烷酮 | CAS号118581-53-6 3-trimethylsily... | CAS号54755-69-0 2-羟基-4-苄基丁氧基羰基胺 丁 酸 | CAS号40732-91-0 2-羟基-4-邻苯二甲酰亚氨基丁酸

4-氨基-2-羟基丁酸甲酯 反应生成2-羟基-4-氨基丁酸
参考文献:Synthesis Of 4-Amino-2-Hydroxybutyric Acids
标题:Synthesis Of 4-Amino-2-Hydroxybutyric Acids
摘要:1,3-双极加成反应中,硝酸酯1与丙烯酸甲酯和甲基克罗通酸反应,得到相应的加成物2和6.这些加成物转化为4-氨基-2-羟基丁酸5和8.
Doi:10.1246/cl.1975.965

专利信息

专利号:US-5763587-A
优先权日:1987-11-27
标题:Process for the synthesis of amikacin
发明人：MANGIA ALBERTO
权利人:GIST BROCADES ITALY SPA
摘要:In the synthesis of amikacin, having the formula: (I) by acylation of a diprotected derivative of kanamycin A with a reactive derivative of L-(-)-4-amino-2-hydroxybutyric acid, the selection of the reaction solvent and of the pH conditions permit the industrial economically and the synthesis yield to be improved.

专利号:US-4902790-A
优先权日:1985-10-10
标 题 :Novel process for the synthesis of amikacin
发明人：MANGIA ALBERTO; GIOBBIO VICENZO; ORNATO GIORGIO
权利人:PIERREL SPA
摘要:A novel process for the synthesis of amikacin starting from kanamycin A protected at the positions 3 and 6' is described comprising the reaction of kanamycin A with a salt of a bivalent metal cation selected from zinc, nickel, iron, cobalt, manganese, copper and cadmium in the presence of water as the solvent or co-solvent followed by the in situ reaction of the resulting complex with a reactive derivative of L-amino-2-hydroxy-butyric acid, removal of the metal cation of the protecting groups and purification of the thus obtained raw product. The acylation under these conditions is extremely selective.

专利号:US-12122769-B2
优先权日:2017-10-19
标题 :Synthesis of antibacterial aminoglycoside analogs
发明人：TREND RAISSA; DAPPEN MICHAEL; HENRY CHRISTOPHER E; GOLDBLUM ADAM AARON; AGGEN JAMES BRADLEY; MENDONÇA RICARDO FILIPE DE JESUS GONÇALVES; SARDINHA JOÃO CARLOS FALCÃO
权利人:CIPLA USA INC
摘要:The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds, as well as to related intermediates, and crystal forms thereof, useful in such methods.

专利号:EP-3697797-A1
优先权日:2017-10-19
标题 :Synthesis of antibacterial aminoglycoside analogs

专利号:CN-111655709-A
优先权日:2017-10-19
标 题:Synthesis of Antibacterial Aminoglycoside Analogs

专利号:WO-2019079613-A1
优先权日:2017-10-19
标题:SYNTHESIS OF ANTIBACTERIAL AMINOGLYCOSIDE ANALOGUES