CAS: 131747-63-2; 4-Bromopicolinaldehyde

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2-甲基吡啶氧化物置于selenium(Iv) Oxide,乙酰溴,硫酸,硝酸,三氟乙酸酐体系中,用 1,4-二氧六环,二氯甲烷 用作溶剂,化学反应 94.5H,反应生成4-溴吡啶-2-甲醛
参考文献:通过改变芳香族供体基团的碱度来调节过渡金属联吡啶的配合物的性质
标题:通过改变芳香族供体基团的碱度来调节过渡金属联吡啶的配合物的性质
摘要:联吡啶(3,7-二氮杂双环[3.3.1]壬烷)是非常刚性和高度组织化的配体,在配位化学领域得到广泛应用,它们的过渡金属配合物的氧化还原电势在高氧氧化反应中很重要.价铁络合物,铜络合物催化的叠氮化和64 Cu铜正电子发射断层显像剂成像.在这里,我们显示了15个四齿联吡啶的铜(II)配合物的氧化还原电势和稳定性常数可以通过取代吡啶环来改变(氧化还原电势在约450 Mv以上的变化和复合物稳定性在约10 Mv以上的变化)日志单位).还表明,这些变化可以通过p K A预测.吡啶基团的值以及取代基的哈米特参数,以及基于密度泛函理论的能量分解分析,还可以使人们准确地预测氧化还原电势和随之而来的配合物稳定性.结果表明,主要贡献来自于静电相互作用能,因此吡啶供体基团的部分电荷也与氧化还原电势相关.
Doi:10.1021/ic4004214

专利信息

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:US-2018222892-A1
优先权日:2012-07-03
标 题 :Heterocyclic modulators of lipid synthesis

专利号:EP-3083583-B1
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof

专利号:CA-2934251-A1
优先权日:2013-12-20
标题:A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer

专利号:EP-3083583-A1
优先权日:2013-12-20
标题 :Heterocyclic modulators of lipid synthesis and combinations thereof