CAS: 116821-47-7; Fmoc-Gaba-Oh

相似化合物

5105-78-2 56-12-2 57294-38-9

上下游产品

(fluorenylmethoxy)carbonyl chloride 4-amino-n-butyric acid methyl 4-(9-fluorenylmethylcarbonyl)amino-butanoate N-(9-fluorenylmethoxycarbonyl)-4-aminobutyric acid 1,1-dimethylallyl ester(3-{Benzyl-[3-(trityl-amino)-propyl]-carbamoyl}-propyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

📜N-(9-Fluorenylmethoxycarbonyl)-4-Aminobutyric Acid 1,1-Dimethylallyl Ester置于四(三苯基膦)钯 N-甲基吗啉体系中,用 四氢呋喃 用作溶剂,以90%的收率获得4-(芴甲氧羰基氨基)丁酸
参考文献:作为羧酸保护基的1,1-二甲基烯丙基酯的常规合成方法.
标题:作为羧酸保护基的1,1-二甲基烯丙基酯的常规合成方法.
摘要:[反应:请参见文本]通过两步将羧酸高收率转化为其1,1-二甲基烯丙基(dma)酯.钯催化的dma酯的脱保护显示与叔丁基,苄基和fmoc保护基相容,并且fmoc的脱保护可以在dma酯存在下选择性进行.Dma酯还显示出对亲核攻击的抵抗力,这表明当需要避免酸性脱保护条件时,它们可作为叔丁基酯的替代品.
Doi:10.1021/ol0476117

专利信息

专利号:US-2009171097-A1
优先权日:2005-11-22
标题 :Automated solid phase synthesis of pyrrole-imidazole polyamide
发明人：SUGIYAMA HIROSHI; DOHNO CHIKARA; FUKUDA NOBORU
权利人:SUGIYAMA HIROSHI; DOHNO CHIKARA; FUKUDA NOBORU
摘要:A synthesis method for pyrrole-imidazole polyamide is automated at a higher level and can produce a product with a high yield in a more stable manner. In a solid phase synthesis method, the automated synthesis of a polyimide can be promoted by using HCTU as a condensation-activator, the yield of a product can be increased by charging a monomer in a solid form, and a pyrrole-imidazole polyamide having any sequence can be synthesis by combining the synthesis method with a manual synthesis with an acid chloride.

专利号:US-7067622-B2
优先权日:2001-06-25
标题 :Method of the solid phase synthesis of pyrrole-imidazole polyamide
发明人：SUGIYAMA HIROSHI; IIDA HIROKAZU; SAITO ISAO; SAITO TAKASHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:It is intended to provide a method of producing a pyrrole-imidazole polyamide whereby a longer pyrrole-imidazole polyamide can be conveniently synthesized and a peptide (protein) can be easily transferred. According to this method, a pyrrole-imidazole polyamide having a carboxylate group which can be excised from a solid phase carrier at its end, makes it possible to directly transfer various functional groups and can exactly distinguish DNA sequences can be efficiently produced. A method of synthesizing a pyrrole-imidazole polyamide characterized by performing automatic synthesis by the solid phase Fmoc method with the used of a peptide synthesizer; a pyrrole-imidazole polyamide having a carboxyl group at its end obtained by this method; a pyrrole-imidazole polyamide having a DNA alkylation agent transferred into the carboxyl group at the end of the above-described pyrrole-imidazole polyamide; and a sequence-specific DNA alkylation method characterized by using the above compound.

专利号:US-7026114-B1
优先权日:1995-09-13
标 题:Methods and compositions for monitoring polymer array synthesis
发明人：BARONE ANTHONY D; MC GALL GLENN H; CHAI EVELYN; NGO NAM QUOC
权利人:AFFYMETRIX INC
摘要:VLSIPSâ„¢ manufacturing processes are of increasing commercial importance. The present invention provides methods and compositions for monitoring the efficiency and quality of polymer synthesis in VLSIPSâ„¢ arrays. Methods for monitoring polymer synthesis in an array on a substrate are provided. Monoisomeric labels for the labeling of synthetic polymer arrays are provided. Methods and compositions for post-synthetically labeling polymers in polymer arrays are also provided.

专利号:US-5916899-A
优先权日:1996-10-18
标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：KIELY JOHN S; GRIFFITH MICHAEL C
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-11471537-B2
优先权日:2017-04-05
标题 :Oligomer extended insulin-Fc conjugates
发明人：MOELLER TAGMOSE TINA; MADSEN PETER; KJELDSEN THOMAS BOERGLUM; PRIDAL LONE; DE MARIA LEONARDO; LIN ZHAOSHENG; Wan zhe; ZHANG YUANYUAN; LYKKE LENNART; MUENZEL MARTIN WERNER BORCHSENIUS; KODRA JANOS TIBOR
权利人:NOVO NORDISK AS
摘要:This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to novel Fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.