CAS: 1125812-58-9; 1-(3-Chloro-5-(Trifluoromethyl)Phenyl)-2,2,2-Trifluoroethanone

相似化合物

321-31-3 130336-16-2 721-37-9

上下游产品

trifluoroacetic acid-methyl ester 1-chloro-3-iodo-5-(trifluoromethyl)benzene ethyl trifluoroacetate, 1-bromo-3-chloro-5-(trifluoromethyl)benzene methyl 4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-1-naphthalenecarboxylate (E)-4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide (Z)-4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide 4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

2-氨基-5-溴三氟甲苯置于氯化亚砜,硫酸,Magnesium体系中,用 2-甲基四氢呋喃,二氯甲烷,水 用作溶剂,化学反应 12.0H,反应生成1-(3-氯-5-(三氟甲基)苯基)-2,2,2-三氟乙酮
参考文献:一种合成3-氯-5-三氟甲基三氟苯乙酮的方法
标题:一种合成3-氯-5-三氟甲基三氟苯乙酮的方法
摘要:本发明公开了一种合成3‑氯‑5‑三氟甲基三氟苯乙酮的方法,包括:邻氨基三氟甲苯先溴代再氯代,得到4‑溴‑2‑氯‑6‑三氟甲基苯胺;4‑溴‑2‑氯‑6‑三氟甲基苯胺经过重氮化后,用次磷酸或乙醇处理,得到脱氨基化合物1‑溴‑3‑氯‑5‑(三氟甲基)苯;1‑溴‑3‑氯‑5‑(三氟甲基)苯用镁屑做成格氏试剂,与酰化试剂发生亲核反应得到3‑氯‑5‑三氟甲基三氟苯乙酮.该路线使用的起始原料邻氨基三氟甲苯为价格便宜的常见化学品,各步反应所得产物纯度好且收率都较高,对环境污染相对较小,有望用于规模化工业生产.

专利信息

专利号:WO-2024175691-A1
优先权日:2023-02-24
标题 :Process for the preparation of substituted chalcones
发明人：BOBNAR JERNEJ
权利人:KRKA D D NOVO MESTO
摘要:The invention relates to an improved process for the preparation of substituted chalcones using a base that plays double role in the process, as it removes free water and catalyzes aldol condensation. Consequently, the process is cost efficient and is easily scalable to industrial level. The substituted chalcones are useful intermediates in the synthesis of isoxazolines such as Fluralaner, Afoxolaner and Sarolaner, which are known systemic insecticides and acaricides.

专利号:CN-113651765-A
优先权日:2021-08-20
标题 :Synthesis of Aforana