专利号:WO-2023102600-A1 优先权日:2021-12-06 标题:Synthesis of amphiphilic block copolymers and polymeric nanofibers produced therefrom 发明人:ZETTERLUND PER B; ISHIZUKA FUMI; KIM HYUN JIN; CHATANI SHUNSUKE; NIINO HIROSHI 权利人:NEWSOUTH INNOVATIONS PTY LTD 摘要:The present disclosure relates to the field of synthesis of block copolymers, and polymeric nanofibers having a core-shell morphology produced therefrom. The present disclosure relates to the field of synthesis of block copolymers where one block is more hydrophobic than the other block and is a different composition. The disclosure also relates to uses of these polymeric nanofibers in various applications, such as reinforcing a polymeric matrix and for coatings applications.
专利号:EP-0020401-B1 优先权日:1978-09-21 标 题 :Improved process for the synthesis of 1,4-diaza-2-cycloalkanone and substituted derivatives thereof 摘要:Improved process for the synthesis of 1,4-diaza-2-cycloalkanones and substituted derivatives thereof involving solid-liquid phase transfer phenomenon. More specifically, the subject compounds are prepared by combining a substituted diamine and suitable coreactant in the presence of a phase transfer catalyst and caustic.
专利号:US-RE46218-E 优先权日:2011-01-05 标 题 :Process for the synthesis of agomelatine 发明人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI 权利人:SERVIER LAB 摘要:Process for the industrial synthesis of the compound of formula (I)
专利号:US-8835661-B2 优先权日:2011-08-26 标 题:Process for the synthesis of C11 and C12 omega-aminoalkanoic acid esters comprising a nitrilation step 发明人:COUTURIER JEAN-LUC; DUBOIS JEAN-LUC 权利人:COUTURIER JEAN-LUC; DUBOIS JEAN-LUC; ARKEMA FRANCE 摘要:A process for the synthesis of C11 and C12 ω-amino-alkanoic acid esters including a step of continuous nitrilation in the gas phase or in a mixed gas-liquid phase, a step of metathesis and a step of reduction by hydrogenation, using, as raw material, C10 and C11 ω-alkenoic acid esters.
专利号:US-8748651-B2 优先权日:2008-11-17 标题:Method for the synthesis of an omega-amino acid or ester starting from a monounsaturated fatty acid or ester 发明人:DUBOIS JEAN-LUC 权利人:DUBOIS JEAN-LUC; ARKEMA FRANCE 摘要:The invention relates to a method for the synthesis of ω-amino alkanoic acids or esters thereof starting from unsaturated natural fatty acids passing through an ω-unsaturated nitrile intermediate compound.
专利号:US-2004203036-A1 优先权日:2001-07-09 标 题 :Multimer polynucleotide synthesis 发明人:STENGELE KLAUS-PETER; PFLEIDERER WOLFGANG 摘要:The present invention relates to a process for the preparation of polynucleotides, whereby under suitable usual conditions the free 5′-hydroxy group, whose terminal 3′-hydroxy group contains a usual protecting group, is reacted with a hydroxy group, derivatized in a previous reaction step to a phosphite amidoester, phosphpotriester or phosphonic acid ester, whereby said hydroxy group is a 3′-hydroxy function of a free or solid phase bound polynucleotide, or a solid phase bound hydroxy function. n Further the present invention relates to a kit for performing a process according to the invention, which contains at least one or more selected oligonucleotides, having a free 5′-hydroxy group and a protected 3′-hydroxy group. Further on, the present invention relates to new oligonucleotides and their use as building blocks for the synthesis of polynucleotides in the process according to the invention. n Furthermore the present invention relates to the use of the process according to the invention or the use of the kits for the preparation of poly/oligonucleotides resp. polynucleotide libraries or nucleic acid chips.
参考标题:An Alternative Synthesis Of The Non-Small Cell Lung Carcinoma Drug Afatinib 作者:Tatjana Kovacevic,Milan Mesic,Amir Avdagic,Miroslav Zegarac |发布日期:2018.11 摘要:Afatinib (Bibw2992) Is The Anticancer Drug Developed By Boehringer Ingelheim. This Work Is Reporting The Synthesis Of The Afatinib Using A New Route By Ullmann-Goldberg Reaction From Corresponding 4-Anilinoquinazoline Iodide As The Last Step In The Synthesis. This Route Was Not Described Previously And It Could Be Used For Synthesis Of Afatinib Analogues.
合成参考文献
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