CAS: 104700-97-2; (10S,13R,14R,17S)-17-((R)-7-Hydroxy-6-Methylhept-5-En-2-yl)-4,4,10,13,14-Pentamethyl-1,2,4,5,6,10,12,13,14,15,16,17-Dodecahydro-3H-Cyclopenta[a]Phenanthren-3-One

上下游产品

Lanosta-8,24-Dien-3-One 08/04/5539
羊毛甾醇 Tirucallol 79-63-0

📜羊毛甾醇置于草酰氯,二异丁基氢化铝,对甲苯磺酸,二甲基亚砜,间氯过氧苯甲酸,Lithium Bromide体系中,用 四氢呋喃,正己烷,二氯甲烷,氯仿,丙酮,甲苯,苯 用作溶剂,化学反应 58.18H,反应生成灵芝醇 A
参考文献:灵芝三醇及其立体异构三醇的半合成及生物学评价
标题:灵芝三醇及其立体异构三醇的半合成及生物学评价
摘要:灵芝灵芝的一种生物活性羊毛脂三萜烯-灵芝三醇的首次合成已通过9个步骤以15.3%的收率完成,并合成了其三种立体异构三醇和灵芝多酚a.导致该异构体家族的关键步骤涉及重建通过立体选择性和化学选择性膦酸酯反应合成三取代烯烃,并通过羊毛甾酮衍生的环氧化物的温和酸性开放形成异常的δ7,9(11)-二烯核.灵芝三醇对乳腺癌细胞的抑制和增殖显示出有希望的活性.测定了灵芝三醇及其异构体对细胞增殖的影响.Ic 50 对于灵芝三醇,在乳腺癌细胞系mcf-7和mda-Mb-231上分别发现了5.8和9.7μm的值.
Doi:10.1021/np200205N

专利信息

专利号:US-2004018210-A1
优先权日:2001-01-31
标 题 :Cholesterol-lowering agent
发明人：HAJJAJ HASSAN; MACE CATHERINE; NIEDERBERGER PETER; FAY LAURENT-BERNARD
摘要:A hypocholesterolaemic agent and a process for its preparation by extraction from edible fungi, along with methods of use of the agent for preventing the synthesis of cholesterol in a person. These methods include the administration of the agent alone or in a food or beverage. The foods or beverages that contain this agent are another feature of the invention.